[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100611178":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":29,"locations":34,"responsibleParty":53,"collaborators":24,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":24,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":24,"enrollmentInfo":64,"targetDuration":24,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":75,"overallStatus":78,"whyStopped":24,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Medical University of Warsaw","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"15 minute Pringle manouver with 10 minute reperfusion","EXPERIMENTAL","Hepatic pedicle clamping for 15 minutes, followed by a 10-minute declamping period during liver transection.",[13],"Procedure: Pringle manouver",{"label":15,"type":10,"description":16,"interventionNames":17},"45 minute Pringle manouver with 15 minute reperfusion","Hepatic pedicle clamping for 45 minutes, followed by a 15-minute declamping period during liver transection.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"PROCEDURE","Pringle manouver","The Pringle maneuver involves temporary clamping of the hepatic pedicle during liver resection to reduce blood loss during parenchymal transection.",[9,15],null,[26],{"name":27,"affiliation":5,"role":28},"Emilia Kruk, MD","PRINCIPAL_INVESTIGATOR",[30],{"name":27,"role":31,"phone":32,"phoneExt":24,"email":33},"CONTACT","+48 22 599 2545","emilia.kruk1@wum.edu.pl",[35],{"facility":36,"status":24,"city":37,"state":24,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Department of General, Transplant and Liver Surgery, Medical University of Warsaw","Warsaw","02-091","Poland","PL",{"type":42,"coordinates":43},"Point",[44,45],21.01178,52.22977,{"lat":45,"lon":44},[48,50,52],{"name":27,"role":31,"phone":49,"phoneExt":24,"email":33},"+ 48 22 599 2545",{"name":24,"role":31,"phone":24,"phoneExt":24,"email":51},"emiliakruk1@gmail.com",{"name":27,"role":28,"phone":24,"phoneExt":24,"email":24},{"type":54,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR","100611178","15-vs-45-minute-pringle-maneuver-in-liver-cancer-resection-randomized-noninferiority-trial-100611178",false,"NCT07237204","15 vs 45 Minute Pringle Maneuver in Liver Cancer Resection: Randomized Noninferiority Trial","A Prospective, Randomized Noninferiority Trial Comparing 15- and 45-minute Pringle Maneuvers During Liver Resection for Oncologic Indications.","Inclusion Criteria:\n\n* Diagnosis of a primary or secondary malignant liver tumor.\n* Age \\> 18 years.\n* Patient deemed eligible for liver resection.\n* WHO performance status ≤ 2.\n* Ability to provide written informed consent.\n\nExclusion Criteria:\n\n* Liver cirrhosis.\n* Liver dysfunction classified as Child-Pugh class B or C.\n* Repeat hepatectomy.\n* Prior ablation or chemoembolization of hepatic lesions.\n* Prior portal vein branch embolization.\n* Planned or performed ALPPS procedure.\n* Concomitant resection of any organ other than the gallbladder during the same operation.","ALL","18 Years",{"count":65,"type":66},600,"ESTIMATED","INTERVENTIONAL",[69],"NA","The goal of this clinical trial is to evaluate the safety of two durations of the Pringle maneuver in adults undergoing elective liver resection for malignant tumors. The main questions it aims to answer are:\n\nIs the incidence of post-hepatectomy liver failure different between 15-minute and 45-minute Pringle maneuver durations?\n\n* Do the durations differ in operative time or intraoperative blood loss?\n* Researchers will compare patients randomized 1:1 to 15 minutes vs 45 minutes of Pringle clamping to see if outcomes are non-inferior between groups.\n\nParticipants will:\n\n* Undergo standard oncologic hepatectomy with the assigned Pringle duration.\n* Receive routine perioperative assessments, including laboratory tests and clinical evaluations.\n* Attend follow-up visits at approximately 6 months, 1 year, and 3 years after surgery.",[72,73,74],"Liver Cancer, Adult","Metastases to Liver","Liver Malignant Tumors",[21,76,77],"Liver malignancy","Liver resection","NOT_YET_RECRUITING","2025-11-14",{"date":81,"type":82},"2025-11-19","ACTUAL",{"date":84,"type":66},"2025-12-01",{"date":86,"type":66},"2030-11-01",{"name":5,"class":6},1]