[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100581502":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":19,"centralContacts":20,"locations":19,"responsibleParty":26,"collaborators":19,"id":28,"slug":29,"hasResults":30,"nctId":31,"briefTitle":32,"officialTitle":32,"acronym":19,"eligibilityCriteria":33,"healthyVolunteers":30,"sex":34,"minAge":35,"maxAge":36,"enrollmentInfo":37,"targetDuration":19,"studyType":40,"phases":41,"briefSummary":43,"conditions":44,"keywords":46,"overallStatus":52,"whyStopped":19,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":19},{"fullName":5,"class":6},"Xijing Hospital","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Comparative study of different groups","This study is planned to include approximately 25 normal volunteers and 40 patients with dysfunctional brain diseases. The screened subjects will undergo multimodal imaging data acquisition using integrated PET\u002FMR (GE Signa). The SUV ratio (SUVR) of each brain region will be obtained using the cerebellum as a reference, and differences in \\[18F\\]DPA-714 uptake between patients and normal controls will be compared using voxel-based imaging analysis. PCA-based analysis of the distribution pattern of TSPO radioabnormalities in different types of patients. Pearson correlation-based analysis of the correlation between neuroimmune activation and structural and functional parameters.",[12],"Diagnostic Test: 18F-DPA-714 PET\u002FMR scan",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"DIAGNOSTIC_TEST","18F-DPA-714 PET\u002FMR scan","Saline intravenous solution of 18F-DPA-714 administered at 0.1 mCi\u002Fkg by bodyweight",[9],null,[21],{"name":22,"role":23,"phone":24,"phoneExt":19,"email":25},"Ying Guo Ying Guo","CONTACT","0086+15991459177","guoying01192022@163.com",{"type":27,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100581502","18f-dpa-714-petmr-in-dysfunctional-brain-diseases-100581502",false,"NCT06851143","18F-DPA-714 PET\u002FMR in Dysfunctional Brain Diseases","Inclusion Criteria:\n\n* Dysfunctional disorders diagnosed according to the guidelines include: cognitive disorders, movement disorders, disorders of consciousness-like disorders, and autoimmune encephalitis. Signing the PET\u002FMR informed consent form to volunteer for this study\n\nExclusion Criteria:\n\n* Minors, pregnant women, nursing mothers, those with severe liver or kidney insufficiency, history of allergy to contrast media or other drugs. Diagnosis of viral encephalitis, acute myelitis, idiopathic epilepsy, antibody-negative AIE; diagnosis of any major disease; history of alcohol or drug abuse\u002Fdependence; history of cardiorespiratory disease, oncology, haematological disorders, poorly controlled chronic diseases; contraindications to PET\u002FMR examination. History of head trauma, history of surgery. History of other neurological disorders.","ALL","18 Years","80 Years",{"count":38,"type":39},65,"ESTIMATED","INTERVENTIONAL",[42],"NA","This is a diagnostic pilot study that recruited 25 normal volunteers and 40 patients with dysfunctional brain diseases and performed 18F-DPA-714 PET\u002FMR imaging to evaluate the correlation between the multimodal imaging features of dysfunctional brain diseases, to explore the potential pathological mechanisms of neuroimmune activation, and to further analyse the value of PET\u002FMR-based multimodal imaging in the diagnosis and differential diagnosis of dysfunctional brain diseases. and further analyse the diagnostic and differential diagnostic value of PET\u002FMR-based multimodal imaging in dysfunctional brain diseases.",[45],"Brain Disease",[47,48,49,50,51],"18F-DPA-714 PET\u002FMR","cognitive impairment","dyskinesia","Disorders of consciousness","Autoimmune encephalitis","NOT_YET_RECRUITING","2025-02-26",{"date":55,"type":56},"2025-02-28","ACTUAL",{"date":58,"type":39},"2025-03-01",{"date":60,"type":39},"2027-12-31",{"name":5,"class":6}]