[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100593302":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":17,"locations":26,"responsibleParty":45,"collaborators":47,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":10,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":58,"minAge":10,"maxAge":10,"enrollmentInfo":59,"targetDuration":10,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":10,"overallStatus":29,"whyStopped":10,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Ruijin Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Carotid plaque & carotid atherosclerotic stenosis",null,"Medication or carotid stenting or carotid endarterectomy according to clinical guidelines",[13],{"name":14,"affiliation":15,"role":16},"Jun Liu Jun Liu","Department of Neurology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine Study Chair","STUDY_CHAIR",[18,23],{"name":19,"role":20,"phone":21,"phoneExt":10,"email":22},"JUN LIU Professor","CONTACT","+86-021-64370045","lj11128@rjh.com.cn",{"name":24,"role":20,"phone":21,"phoneExt":10,"email":25},"BIN LIU PhD student","ousi@163.com",[27],{"facility":28,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"Department of neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine","RECRUITING","Shanghai","Shanghai Municipality","200025","China","CN",{"type":36,"coordinates":37},"Point",[38,39],121.45806,31.22222,{"lat":39,"lon":38},[42,43],{"name":19,"role":20,"phone":21,"phoneExt":10,"email":22},{"name":44,"role":20,"phone":21,"phoneExt":10,"email":25},"LIU BIN PhD Student",{"type":46,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[48],{"name":49,"class":50},"National Natural Science Foundation of China","OTHER_GOV","100593302","18f-fdg-and-68ga-fapi-petmr-imaging-of-carotid-artery-plaque-vulnerability-a-clinical-study-in-carotid-artery-plaque-patients-100593302",false,"NCT07004673","18F FDG and 68Ga FAPI PET\u002FMR Imaging of Carotid Artery Plaque Vulnerability: A Clinical Study in Carotid Artery Plaque Patients","Inclusion Criteria:\n\n-Age between 18 and 80 years; Presence of carotid atherosclerotic plaque confirmed by ultrasound within the past two weeks, with carotid intima-media thickness (IMT) ≥ 2 mm (IMT ≥ 1.2 mm is defined as carotid atherosclerosis) or carotid artery stenosis ≥ 50% as indicated by CTA.\n\nExclusion Criteria:\n\n* Absolute or relative contraindications related to PET\u002FMR imaging safety (e.g., metallic implants, MRI phobia, etc.); Patients who have undergone carotid endarterectomy (CEA) or carotid artery stenting (CAS); Pregnant or lactating women; Presence of other vascular diseases, such as vasculitis, moyamoya disease, arterial dissection, etc.; Severe agitation or inability to cooperate with imaging procedures.",true,"ALL",{"count":60,"type":61},100,"ESTIMATED","OBSERVATIONAL","Carotid atherosclerotic plaque rupture is the main cause of ischemic stroke attacks, and early and precise assessment of plaque vulnerability can prevent ischemic stroke. High-resolution MRI can reflect vulnerable plaque features such as thin fibrous caps and large lipid cores, but cannot assess their metabolic information; Fibro-activated proteins (FAPs) of PET are specifically expressed in atherosclerosis and suggest vulnerable plaques by reflecting inflammation-induced fibrosis. The aim of this study was to apply 18F FDG\\&68Ga-FAPI PET\u002FMR imaging to investigate the vulnerability of carotid atherosclerotic plaques, to obtain quantitative evaluation indexes of active fibrosis within carotid plaques, and to clarify the PET\u002FMR characteristics of unstable plaques in carotid arteries",[65,66,67],"Carotid Artery Plaque","Ischemic Stroke","PET \u002F MR","2026-03-03",{"date":70,"type":71},"2026-03-05","ACTUAL",{"date":73,"type":71},"2025-04-12",{"date":75,"type":61},"2026-12-31",{"name":5,"class":6},1]