[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100589499":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":29,"centralContacts":37,"locations":45,"responsibleParty":69,"collaborators":28,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":28,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":28,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":47,"whyStopped":28,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"Shengjing Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"MRE-Guided Surgery Group","EXPERIMENTAL","Participants in this group will undergo preoperative three-dimensional magnetic resonance elastography (3D MRE) in addition to routine MRI. MRE will be used to quantify tumor stiffness and generate a three-dimensional adhesion map. These imaging findings will be provided to the neurosurgical team prior to surgery to assist in planning the surgical approach and anticipating tumor consistency and adhesiveness. Intraoperative outcomes such as resection time, blood loss, and dissection difficulty will be recorded and analyzed in relation to preoperative MRE parameters.",[13,14],"Diagnostic Test: Magnetic Resonance Elastography","Procedure: Intraoperative Assessment and Recording",[16,23],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"DIAGNOSTIC_TEST","Magnetic Resonance Elastography","Participants will undergo preoperative 3D MRE to quantify tumor stiffness and generate adhesion maps. MRE is performed as an adjunct to standard brain MRI, using 60 Hz vibration frequency and specialized elastogram processing software. The resulting stiffness and adhesion data are made available to the neurosurgical team for surgical planning.",[9],[22],"MRE",{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"PROCEDURE","Intraoperative Assessment and Recording","During surgical resection, the neurosurgical team will systematically assess and record tumor stiffness, adhesion to surrounding structures, vascularity, resection time, and technical difficulty using a standardized intraoperative scale. These intraoperative findings will be compared to preoperative MRE parameters to evaluate the diagnostic and predictive value of MRE.",[9],null,[30,33,35],{"name":31,"affiliation":5,"role":32},"Yu Shi, MD","PRINCIPAL_INVESTIGATOR",{"name":34,"affiliation":5,"role":32},"Anhua Wu, MD",{"name":36,"affiliation":5,"role":32},"Wen Cheng, MD",[38,42],{"name":31,"role":39,"phone":40,"phoneExt":28,"email":41},"CONTACT","+86 189 4025 9980","18940259980@163.com",{"name":36,"role":39,"phone":43,"phoneExt":28,"email":44},"15040235535","cmu071207@163.com",[46],{"facility":5,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"RECRUITING","Shenyang","Liaoning","110000","China","CN",{"type":54,"coordinates":55},"Point",[56,57],123.43278,41.79222,{"lat":57,"lon":56},[60,61,63,65,67],{"name":31,"role":39,"phone":40,"phoneExt":28,"email":41},{"name":34,"role":39,"phone":62,"phoneExt":28,"email":44},"+86 189 0092 5766",{"name":64,"role":32,"phone":28,"phoneExt":28,"email":28},"Yu Shi",{"name":66,"role":32,"phone":28,"phoneExt":28,"email":28},"Anhua Wu",{"name":68,"role":32,"phone":28,"phoneExt":28,"email":28},"Wen Cheng",{"type":32,"investigatorFullName":64,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":28,"oldOrganization":28},"Professor","100589499","3d-mre-based-evaluation-of-meningioma-mechanical-properties-and-histological-features-100589499",false,"NCT06955208","3D MRE-Based Evaluation of Meningioma Mechanical Properties and Histological Features","Evaluation of Meningioma Mechanical Properties and Histological Features Using Three-Dimensional Magnetic Resonance Elastography","Inclusion Criteria:\n\n* All patients undergoing meningeoma resection surgery are eligible for inclusion in the study cohort.\n\nExclusion Criteria:\n\n* Patients with metallic implants or foreign bodies in their bodies (pacemakers, artificial metallic heart valves, metal joints, metal implants, and those who can not remove dentures, insulin pumps, or contraceptive rings)\n* Pregnant women in the first trimester (within three months)\n* Patients with severe claustrophobia or anxiety\n* Patients with severe fever\n* Patients who can not tolerate MRE\n* Patients with vascular malformations and aneurysms.\n* Patients who do not sign an informed consent",true,"ALL","18 Years","80 Years",{"count":83,"type":84},300,"ESTIMATED","INTERVENTIONAL",[87],"NA","This prospective single-center study aims to evaluate the feasibility and clinical utility of three-dimensional magnetic resonance elastography (3D MRE) in assessing tumor stiffness and adhesion in patients with meningioma undergoing surgical resection. By correlating preoperative MRE-derived stiffness and adhesion maps with intraoperative findings and histopathological features, the study seeks to determine whether MRE can serve as a noninvasive imaging biomarker for surgical planning, risk stratification, and prediction of tumor behavior.",[90],"Meningioma",[92,90,93,94,95],"Magnetic resonance elastography","Stiffness","Adhesion","Neurosurgery","2026-02-10",{"date":98,"type":99},"2026-02-12","ACTUAL",{"date":101,"type":99},"2022-10-19",{"date":103,"type":84},"2027-10-09",{"name":5,"class":6},1]