[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100297566":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":35,"responsibleParty":53,"collaborators":19,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":19,"eligibilityCriteria":61,"healthyVolunteers":58,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":19,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":19,"overallStatus":38,"whyStopped":19,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"University Health Network, Toronto","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"fMRI-based programming","EXPERIMENTAL","DBS patients will undergo fMRI scanning while on different stimulation settings. The results will be fed to the programming clinician (movement disorder neurologist) to aid the conventional programming process at the clinician's discretion.",[13],"Other: fMRI",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"fMRI","DBS patients will undergo fMRI scanning. For each patient, scans will be performed using a selection of DBS settings. fMRI responses will be analysed to evaluate brain responses on different DBS settings. These results will be provided to the programming clinician to guide them choose the optimal setting for each patient at the clinician's discretion.",[9],null,[21],{"name":22,"affiliation":5,"role":23},"Andres Lozano","PRINCIPAL_INVESTIGATOR",[25,30],{"name":26,"role":27,"phone":28,"phoneExt":19,"email":29},"Alexandre Boutet, MD\u002FMSc","CONTACT","(647) 463-5513","alexandre.boutet@mail.utoronto.ca",{"name":31,"role":27,"phone":32,"phoneExt":33,"email":34},"Tasnuva Hoque, BHA","4166035800","2797","tasnuva.hoque@uhn.ca",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Toronto Western Hospital","RECRUITING","Toronto","Ontario","M5T2S8","Canada","CA",{"type":45,"coordinates":46},"Point",[47,48],-79.39864,43.70643,{"lat":48,"lon":47},[51],{"name":52,"role":27,"phone":28,"phoneExt":19,"email":29},"Alexandre Boutet",{"type":23,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"Andres M. Lozano","Neurosurgeon","100297566","3t-mri-in-patients-with-deep-brain-stimulation-dbs-100297566",false,"NCT03153670","3T MRI in Patients With Deep Brain Stimulation (DBS)","Inclusion Criteria:\n\n* Age between 18 and 85 years of age\n* Participants must be planned to undergo, or have undergone implantation of DBS electrodes\n* Participants must be able to understand the purpose of this research and must sign the informed consent form.\n* Participants must understand that the role of this research is to enhance our understanding of brain functioning and that he\u002Fshe will not directly or indirectly benefit from the study.\n\nExclusion Criteria:\n\n* Participants who have serious cognitive or psychological impairments and cannot give informed consent.\n* Participants who are unable to effectively or efficiently communicate, for example patients suffering from speech deficits (dysarthria, aphasia) or are non-English speaking.","ALL","18 Years","85 Years",{"count":66,"type":67},250,"ESTIMATED","INTERVENTIONAL",[70],"NA","Deep brain stimulation (DBS) is an established treatment for advanced Parkinson's disease, medically refractory tremor, dystonia and obsessive compulsive disorder. Several hypotheses driven DBS trials are underway to study modulation of circuit dysfunction in other neurological and psychiatric disorders like epilepsy, Alzheimer's disease and depression. Recent reports suggest profound effects of DBS on the anatomy and function of downstream areas in the brain. For example electrical stimulation of limbic circuits is associated with increase in hippocampal neurogenesis. Similarly, stimulation of subthalamic nucleus (STN) or globus pallidus (GPi) results in activation of cortical motor circuits. Non-invasive imaging modalities are increasingly being employed in these investigations to better understand the effects of DBS on the structure and function of the brain.\n\nThere have been important advances in MRI and we now have MRI which provides higher resolution and higher quality brain images. More specifically, the investigators propose to use MRI to perform functional magnetic resonance imaging (i.e. fMRI) to assess the effects of deep brain stimulation on brain function and to assess whether fMRI can be used as an adjunct to improve clinical practice in these patients.",[73],"Neuro-Degenerative Disease","2024-05-07",{"date":76,"type":77},"2024-05-08","ACTUAL",{"date":79,"type":77},"2017-06-01",{"date":81,"type":67},"2030-12-01",{"name":5,"class":6},1]