[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645039":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":25,"locations":31,"responsibleParty":48,"collaborators":24,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":24,"eligibilityCriteria":58,"healthyVolunteers":54,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":24,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":24,"overallStatus":34,"whyStopped":24,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"University of British Columbia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Treadmill walking with blood flow restriction","EXPERIMENTAL","Treadmill walking with blood flow restriction performed 3 days per week for 6 weeks.",[13],"Other: Exercise",{"label":15,"type":16,"description":17,"interventionNames":18},"Treadmill Walking","ACTIVE_COMPARATOR","Treadmill walking performed 3 days per week for 6 weeks.",[13],[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Exercise","In both groups participants will complete treadmill walking on 3 days per week for 6 weeks. During the first week participants will walk continuously for 21 minutes during each training session which will be increased to 32 minutes per training session for weeks 2-6. In both groups the treadmill speed and grade will be set to elicit 40-50% heart rate reserve. In the BFR group the cuffs will be inflated based on each participants individualized limb occlusion pressure (LOP). The cuffs will remain inflated for the entire session but will deflate for 1 min every 10 min based on safety recommendations. The percentage of LOP will progressively increase over the course of the intervention. Weeks 1 and 2 will be completed at 60% LOP, after which pressure will increase by 5% each subsequent week, corresponding to 65%, 70%, 75%, and 80% LOP during weeks 3, 4, 5, and 6, respectively.",[15,9],null,[26],{"name":27,"role":28,"phone":29,"phoneExt":24,"email":30},"Jonathan P Little, PhD","CONTACT","250-807-9876","jonathan.little@ubc.ca",[32],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"University of British Columbia Okanagan","RECRUITING","Kelowna","British Columbia","V1V 1V7","Canada","CA",{"type":41,"coordinates":42},"Point",[43,44],-119.48568,49.88307,{"lat":44,"lon":43},[47],{"name":27,"role":28,"phone":29,"phoneExt":24,"email":30},{"type":49,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Jonathan Little","Professor","100645039","6-weeks-of-blood-flow-restriction-training-on-immune-cell-function-and-bioenergetics-100645039",false,"NCT07676305","6-Weeks of Blood Flow Restriction Training on Immune Cell Function and Bioenergetics","Impact of 6-Weeks of Blood Flow Restriction Training on Immune Cell Function and Bioenergetics in Adults withT2D","Inclusion Criteria:\n\nA. Aged 19-64 years. B. Diagnosed with type 2 diabetes with current HbA1c 5.7-9.0% C. Completing \\\u003C150 minutes of moderate-vigorous physical activity per week.\n\nExclusion Criteria:\n\nA. Chronic musculoskeletal condition or recent (within 2 years) cardiovascular event preventing participation in exercise.\n\nB. Unstable type 2 diabetes medication of the last 3 months C. Absolute contraindications to BFR (i.e., peripheral vascular disease) D. A self-reported diagnosis of low iron concentrations, anemia, or being treated for these conditions E. A diagnosis of any red blood cell-altering condition (i.e., sickle cell anemia, poikilocytosis) F. Currently living with any cardiovascular disease, which would impact the ability to participate in exercise safely G. Currently prescribed any medication which would impact the ability to use a heart rate monitor to accurately track intensity","ALL","19 Years","64 Years",{"count":63,"type":64},20,"ESTIMATED","INTERVENTIONAL",[67],"NA","To conduct a randomized control trial to determine the impact of 6-weeks of blood flow restriction training on immune cell function and bioenergetics in adults living with type 2 diabetes.",[70],"Type 2 Diabetes","2026-06-23",{"date":73,"type":74},"2026-06-30","ACTUAL",{"date":76,"type":74},"2026-02-11",{"date":78,"type":64},"2027-12-31",{"name":5,"class":6},1]