[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100580141":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":40,"responsibleParty":56,"collaborators":59,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":25,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":25,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":86,"overallStatus":43,"whyStopped":25,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Chongqing Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"68Ga-Pentixafor PET\u002FCT group","EXPERIMENTAL","Patients in the 68Ga-Pentixafor PET\u002FCTgroup will first undergo 68Ga-Pentixafor PET\u002FCT, followed by adrenal venous sampling (AVS). The subsequent treatment will be guided based on the diagnostic results.",[13],"Diagnostic Test: 68Ga-Pentixafor PET\u002FCT",{"label":15,"type":10,"description":16,"interventionNames":17},"AVS group","Patients in the adrenal venous sampling (AVS) will first undergo adrenal venous sampling (AVS) , followed by 68Ga-Pentixafor PET\u002FCT. The subsequent treatment will be guided based on the diagnostic results.",[18],"Diagnostic Test: AVS",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DIAGNOSTIC_TEST","68Ga-Pentixafor PET\u002FCT","Patients in the 68Ga-Pentixafor PET\u002FCT group will first undergo 68Ga-Pentixafor PET\u002FCT, followed by adrenal venous sampling (AVS). The subsequent treatment will be guided based on the diagnostic results.\n\nThe diagnosis of unilateral PA was made if LISUVmax ≥1.50 or or unilateral functional adrenal tumor based on 68Ga-Pentixafor PET\u002FCT",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"AVS","Patients in the adrenal venous sampling (AVS) group will first undergo adrenal venous sampling (AVS), followed by 68Ga-Pentixafor PET\u002FCT. The subsequent treatment will be guided based on the diagnostic results.\n\nThe diagnosis of unilateral PA was made LI ≥ 4 or LI 2-4 with contralateral suppression or typical nodule on the dominant side by CT",[15],[31],{"name":32,"affiliation":33,"role":34},"Qifu Li","the Chongqing Primary Aldosteronism Study (CONPASS) Group","STUDY_CHAIR",[36],{"name":32,"role":37,"phone":38,"phoneExt":25,"email":39},"CONTACT","+86 023-89011552","liqifu@yeah.net",[41],{"facility":42,"status":43,"city":44,"state":45,"zip":25,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"The First Affilated Hospital of Chongqing Medical University","RECRUITING","Chongqing","Chongqing Municipality","China","CN",{"type":49,"coordinates":50},"Point",[51,52],106.55771,29.56026,{"lat":52,"lon":51},[55],{"name":32,"role":37,"phone":38,"phoneExt":25,"email":39},{"type":57,"investigatorFullName":32,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"SPONSOR_INVESTIGATOR","Primary investigator",[60,62,64],{"name":61,"class":6},"The Affiliated Hospital Of Southwest Medical University",{"name":63,"class":6},"Changzhi Medical College",{"name":65,"class":6},"First Affiliated Hospital of Kunming Medical University","100580141","68ga-pentixafor-petct-versus-adrenal-vein-sampling-in-diagnosing-unilateral-subtype-of-primary-aldosteronism-concurrent-with-autonomous-cortisol-secretion-predict-100580141",false,"NCT06833437","68Ga-Pentixafor PET\u002FCT Versus Adrenal Vein Sampling in Diagnosing Unilateral Subtype of Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion (PREDICT)","68Ga-Pentixafor PET\u002FCT Versus Adrenal Vein Sampling in Diagnosing Unilateral Subtype of Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion (PREDICT): a Randomized Cross-over Trial","Inclusion Criteria:\n\n* Getting the written informed consent;\n* PA conccurent with autonomous cortisol secretion;\n* Patients with hypertension aged 18-70 years;\n* CT or MRI scan of the adrenal glands with adenoma. Exclusion criteria\n\nExclusion Criteria:\n\n* Unable to complete 68Ga-Pentixafor PET\u002FCT or AVS;\n* Refusal of surgery or contraindications for surgery;\n* PA patients who meet the by-passing AVS criteria \\[i.e., younger than 35 years old, spontaneous hypokalemia, adrenal CT indicated unilateral low-density adenoma (≥1cm), plasma aldosterone \\>300pg\u002Fml\\]\n* Suspicion of familial hyperaldosteronism or Liddle syndrome. \\[i.e., age \\\u003C20 years, hypertension and hypokalemia, or with family history\\];\n* Suspicion of pheochromocytoma or adrenal carcinoma;\n* Patients with actively malignant tumor;\n* Patients who have adrenalectomy history;\n* Long-term use of glucocorticoids;\n* Pregnant or lactating women; with alcohol or drug abuse and mental disorders;\n* Congestive heart failure with New York Heart Association (NYHA) Functional Classification III or IV; History of serious cardiovascular or cerebrovascular disease (angina, myocardial infarction or stroke) in the past 3 months; Severe anemia (Hb\\\u003C60g\u002FL); Serious liver dysfunction or chronic kidney disease aspartate aminotransferase (AST) or alanine transaminase (ALT) \\>3 times the upper limit of normal, or estimated glomerular filtration rate (eGFR) \\\u003C 30 ml\u002Fmin\u002F1.73 m2); Systemic Inflammatory Response Syndrome (SIRS); Uncontrolled diabetes (FBG≥13.3 mmol\u002FL); Obesity (BMI≥35 kg\u002Fm²) or Underweight (BMI≤18 kg\u002Fm²); Untreated aneurysm; Other comorbidity potentially interfering with treatment;\n* Suspected PBMAH or PPNAD;\n* Poor compliance or any other reason deemed unsuitable for inclusion by the investigators;\n* Patients with adrenal insufficiency requiring hormone replacement therapy.","ALL","18 Years","70 Years",{"count":77,"type":78},178,"ESTIMATED","INTERVENTIONAL",[81],"NA","To validate the accuracy of 68Ga-Pentixafor PET\u002FCT and adrenal venous sampling (AVS) in subtype diagnosis of PA\u002FACS patients with adrenal nodules, based on biochemical and clinical remission outcomes, and to determine whether the diagnostic accuracy of 68Ga-Pentixafor PET\u002FCT is non-inferior to AVS.",[84,85],"Primary Aldosteronism","Autonomous Cortisol Secretion",[87,88,89,22,90,91],"Primary aldosteronism","Autonomous cortisol secretion","Adrenal venous sampling","outcome","multicenter randomized crossover trial","2026-02-03",{"date":94,"type":95},"2026-02-05","ACTUAL",{"date":97,"type":95},"2024-08-01",{"date":99,"type":78},"2029-12-31",{"name":32,"class":6},1]