[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100579591":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":33,"locations":42,"responsibleParty":73,"collaborators":75,"id":80,"slug":81,"hasResults":82,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":88,"sex":89,"minAge":90,"maxAge":91,"enrollmentInfo":92,"targetDuration":10,"studyType":95,"phases":10,"briefSummary":96,"conditions":97,"keywords":100,"overallStatus":58,"whyStopped":10,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"IRCCS Fondazione Stella Maris","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Healthy Controls",null,"Subject without any known neurological and psychiatric pathologies",[13],"Other: 7T MR exam",{"label":15,"type":10,"description":16,"interventionNames":17},"CP patients","Patients with pre-, peri- or post-natal brain injury, as documented in a previous brain MRI examination",[13,18],"Other: clinical assessment",[20,24],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"7T MR exam","a 7 Tesla MRI scan, with a functional and anatomical dedicated protocol",[15,9],{"type":6,"name":25,"description":26,"armGroupLabels":27,"otherNames":10},"clinical assessment","A comprehensive clinical assessment before the MRI exam.",[15],[29],{"name":30,"affiliation":31,"role":32},"Laura Biagi, PhD","IRCCS Stella Maris","PRINCIPAL_INVESTIGATOR",[34,38],{"name":30,"role":35,"phone":36,"phoneExt":10,"email":37},"CONTACT","+39050886175","laura.biagi@fsm.unipi.it",{"name":39,"role":35,"phone":40,"phoneExt":10,"email":41},"Giuseppina Sgandurra, MD","+39050886336","giuseppina.sgandurra@fsm.unipi.it",[43,57],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":10},"Fondazione IMAGO7","ACTIVE_NOT_RECRUITING","Calambrone","PISA","56018","Italy","IT",{"type":52,"coordinates":53},"Point",[54,55],10.3,43.58333,{"lat":55,"lon":54},{"facility":5,"status":58,"city":46,"state":59,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":60,"geoPoint":62,"contacts":63},"RECRUITING","Pisa",{"type":52,"coordinates":61},[54,55],{"lat":55,"lon":54},[64,65,66,69,71],{"name":30,"role":35,"phone":36,"phoneExt":10,"email":37},{"name":39,"role":35,"phone":40,"phoneExt":10,"email":41},{"name":67,"role":68,"phone":10,"phoneExt":10,"email":10},"Marta Lancione, PhD","SUB_INVESTIGATOR",{"name":70,"role":68,"phone":10,"phoneExt":10,"email":10},"Pierfrancesco Ambrosi, PhD",{"name":72,"role":68,"phone":10,"phoneExt":10,"email":10},"Michela Tosetti, PhD",{"type":74,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[76,78],{"name":77,"class":6},"University of Parma",{"name":44,"class":79},"UNKNOWN","100579591","7t-anatomo-functional-characterization-of-structures-in-the-action-observation-network-100579591",false,"NCT06826287","7T Anatomo-functional Characterization of Structures in the Action Observation Network","More Than Cerebral Cortex: 7T Anatomo-functional Characterization of Cortical, Subcortical, and Cerebellar Structures Involved in THE Network of Action Observation","7T-ATHENA","For CP patients\n\nInclusion Criteria:\n\n* Patients with pre-, peri- or post-natal brain injury, documented by a previous MRI examination of the brain;\n* Intellectual development within the norm or within the mild deficit area, to guarantee understanding and cooperation in the 7T fMRI study;\n* Understanding of the Italian language;\n\nExclusion Criteria:\n\n* Contraindications to performing the 7T fMRI exam;\n* Neuropsychiatric comorbidity that precludes collaboration in the 7T fMRI study;\n* Lack of capacity to understand and to will;\n* Pregnancy;\n\nFor Healthy Controls\n\nInclusion Criteria:\n\n* Absence of known neurological and psychiatric pathologies;\n* Understanding of the Italian language;\n\nExclusion Criteria:\n\n* Contraindications to performing the 7T fMRI exam;\n* Neuropsychiatric comorbidity that precludes collaboration in the 7T fMRI study;\n* Lack of capacity to understand and to will;\n* Pregnancy;",true,"ALL","11 Years","40 Years",{"count":93,"type":94},40,"ESTIMATED","OBSERVATIONAL","The goal of this study is to explore the anatomical-functional characteristics of the AON circuit (with particular interest for subcortical areas and the cerebellum), and the cortico-subcortical connectivity of the nodes of the AON circuit, using an ultra-high field (7T), high spatial resolution Magnetic Resonance Imaging protocol.\n\nThe main questions it aims to answer are:\n\n* Can we demonstrate the involvement of subcortical areas and cerebellum in the AON circuit in each single-subject?\n* Can we obtain similar results in a small group of patients with Cerebral Palsy (CP), in order to demonstrate the feasibility of this approach for the study of the mechanisms of AON reorganization, after early brain damage?\n* Are different patterns of functional activation correlated to different clinical characteristics of CP patients?\n\nParticipants will perform a 7 Tesla MRI scan, with a functional and anatomical dedicated protocol and will have a comprehensive clinical assessment before the MRI exam.",[98,99],"Brain Function","Cerebral Palsy",[101,102,103,104,105,106],"magnetic resonance imaging","ultra high field","action observation network","cerebral palsy","functional re-organization","neural plasticity","2025-02-12",{"date":109,"type":110},"2025-02-13","ACTUAL",{"date":112,"type":110},"2024-12-02",{"date":114,"type":94},"2025-08-09",{"name":5,"class":6},2]