[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100611451":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":10,"centralContacts":17,"locations":10,"responsibleParty":23,"collaborators":27,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":64,"sex":70,"minAge":10,"maxAge":10,"enrollmentInfo":71,"targetDuration":10,"studyType":74,"phases":10,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":83,"whyStopped":10,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":10},{"fullName":5,"class":6},"Tongji Hospital","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":11},"Cervical Large Cell Neuroendocrine Carcinoma Cohort",null,[12],"Other: Postoperative pathological examination confirmed cervical large cell neuroendocrine carcinoma.",[14],{"type":6,"name":15,"description":15,"armGroupLabels":16,"otherNames":10},"Postoperative pathological examination confirmed cervical large cell neuroendocrine carcinoma.",[9],[18],{"name":19,"role":20,"phone":21,"phoneExt":10,"email":22},"Lin Shitong Doctor","CONTACT","86 02783662379","1131108208@qq.com",{"type":24,"investigatorFullName":25,"investigatorTitle":26,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Lili","Associate Chief Physician",[28,30,33,35,37,39,41,43,45,47,49,51,53,56,58,60],{"name":29,"class":6},"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology",{"name":31,"class":32},"Cancer Research Institute of Zhongshan City","OTHER_GOV",{"name":34,"class":6},"The First Affiliated Hospital of Zhengzhou University",{"name":36,"class":6},"Qilu Hospital of Shandong University",{"name":38,"class":6},"Fujian Province Tumor Hospital",{"name":40,"class":6},"Fujian Maternity and Child Health Hospital",{"name":42,"class":6},"Zhejiang Cancer Hospital",{"name":44,"class":6},"The Third Affiliated Hospital of Kunming Medical College.",{"name":46,"class":6},"Obstetrics & Gynecology Hospital of Fudan University",{"name":48,"class":6},"Women's Hospital School Of Medicine Zhejiang University",{"name":50,"class":6},"National Cancer Center, China",{"name":52,"class":6},"Peking Union Medical College Hospital",{"name":54,"class":55},"The Affiliated Tumor Hospital of Xinjiang Medical University","UNKNOWN",{"name":57,"class":6},"The First Affiliated Hospital of Anhui Medical University",{"name":59,"class":6},"Tianjin Medical University Cancer Institute and Hospital",{"name":61,"class":6},"Renmin Hospital of Wuhan University","100611451","a-chinese-cohort-of-cervical-large-cell-neuroendocrine-carcinoma-100611451",false,"NCT07240753","A Chinese Cohort of Cervical Large Cell Neuroendocrine Carcinoma","Clinical Characteristics and Prognostic Factors of Large Cell Neuroendocrine Carcinoma of the Cervix: A Multicenter, Bidirectional Cohort Study","CN-CLCNEC","Inclusion Criteria: The diagnosis of cervical large cell neuroendocrine carcinoma (LCNEC) was confirmed by histopathological examination, meeting both clinical and histological criteria. The tumor exhibited characteristic features, including large cells with abundant cytoplasm, vesicular nuclei with prominent nucleoli, and a high mitotic rate (\\>10 mitoses\u002F10 HPFs). The growth patterns were predominantly insular, trabecular, or solid, often accompanied by peripheral palisading or rosette formation, along with focal tumor necrosis.\n\n\\-\n\nExclusion Criteria: Mixed cervical LCNEC histology, cases with missing follow-up, or patients lost to contact.\n\n\\-","FEMALE",{"count":72,"type":73},200,"ESTIMATED","OBSERVATIONAL","Cervical large cell neuroendocrine carcinoma (LCNEC) exhibits highly aggressive biological behavior, including strong invasiveness, a high propensity for metastasis, drug resistance, and poor prognosis, necessitating heightened clinical and pathological awareness. This study aims to summarize the clinical characteristics of LCNEC and analyze various prognostic factors to enhance understanding and vigilance toward this disease. Combined with precise pathological diagnosis, improving diagnostic accuracy is crucial for formulating treatment strategies and assessing patient prognosis.",[77],"Uterine Cervical Neoplasms",[79,80,81,82],"Cervical Large Cell Neuroendocrine Carcinoma","Prognosis","High-Risk Factors","Treatment Options","NOT_YET_RECRUITING","2025-11-15",{"date":86,"type":87},"2025-11-21","ACTUAL",{"date":89,"type":73},"2025-12-01",{"date":91,"type":73},"2028-11-01",{"name":25,"class":6}]