[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622333":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":25,"locations":31,"responsibleParty":51,"collaborators":53,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":24,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":24,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":34,"whyStopped":24,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Novlead Inc.","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"iNO 10 ppm Dose Group","EXPERIMENTAL","Participants will receive inhaled nitric oxide at a concentration of 10 ppm, for a minimum of 2 hours per day, over 7 consecutive days.",[13],"Device: Nitric Oxide Generation and Delivery System",{"label":15,"type":10,"description":16,"interventionNames":17},"iNO 40 ppm Dose Group","Participants will receive inhaled nitric oxide at a concentration of 40 ppm, for a minimum of 2 hours per day, over 7 consecutive days.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DEVICE","Nitric Oxide Generation and Delivery System","A device designed to deliver a stable, user-prescribed concentration of nitric oxide gas into the inspiratory circuit of the patient's breathing apparatus for inhalation therapy.",[9,15],null,[26],{"name":27,"role":28,"phone":29,"phoneExt":24,"email":30},"Chenxi Wu, Master","CONTACT","+8615850568410","chenxi.wu@novlead.com",[32],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"The First Affiliated Hospital with Nanjing Medical University","RECRUITING","Nanjing","Jiangsu","210000","China","CN",{"type":41,"coordinates":42},"Point",[43,44],118.77778,32.06167,{"lat":44,"lon":43},[47],{"name":48,"role":28,"phone":49,"phoneExt":24,"email":50},"Ning Ding, Doctor","+8619941515661","dingning@njmu.edu.cn",{"type":52,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR",[54],{"name":33,"class":55},"OTHER","100622333","a-clinical-study-of-inhaled-nitric-oxide-in-patients-with-chronic-obstructive-pulmonary-disease-100622333",false,"NCT07382258","A Clinical Study of Inhaled Nitric Oxide in Patients With Chronic Obstructive Pulmonary Disease","A Prospective, Single-Center Study of Inhaled Nitric Oxide in Individuals Diagnosed With Moderate-to-Severe Chronic Obstructive Pulmonary Disease","Inclusion Criteria:\n\n1. Aged between 40 and 75 years, inclusive.\n2. History of smoking with a cumulative exposure of ≥10 pack-years, and having ceased smoking for at least one month prior to study participation.\n3. Diagnosis of moderate-to-severe COPD confirmed by post-bronchodilator spirometry: FEV1\u002FFVC \\\u003C 0.7 and FEV1 between 30% and 80% of predicted value.\n4. Willing and able to provide written informed consent and comply with all study-related procedures.\n\nExclusion Criteria:\n\n1. Pregnancy or lactation.\n2. Use of nicotine-containing products (e.g., patches, gum) within the past month.\n3. Current diagnosis of asthma or any other active respiratory condition considered non-COPD by the investigator.\n4. Physical obstruction of the nasal passages.\n5. Experienced a COPD exacerbation within the past month requiring initiation or escalation of systemic corticosteroids.\n6. Impaired left ventricular systolic function, defined as left ventricular ejection fraction (LVEF) \\\u003C 50%.\n7. Significant valvular heart disease (moderate\u002Fsevere aortic or mitral stenosis\u002Fregurgitation) or prior mitral valve replacement.\n8. Use of approved pulmonary hypertension medications (e.g., sildenafil, bosentan, prostacyclins) within 30 days prior to screening or during the study.\n9. Participation in another interventional clinical trial involving drugs or devices within 30 days prior to enrollment.\n10. Any other medical or psychiatric condition that, in the investigator's judgment, would compromise patient safety or study integrity.","ALL","40 Years","75 Years",{"count":67,"type":68},16,"ESTIMATED","INTERVENTIONAL",[71],"NA","This clinical trial aims to assess the impact on exercise tolerance and the safety of inhaled nitric oxide in subjects with moderate-to-severe COPD. The findings are expected to contribute to the development of safe and effective therapeutic strategies for COPD management.",[74],"Chronic Obstructive Pulmonary Disease (COPD)",[76],"COPD","2026-01-25",{"date":79,"type":80},"2026-02-02","ACTUAL",{"date":82,"type":80},"2023-05-17",{"date":84,"type":68},"2026-04-30",{"name":5,"class":6},1]