[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100580105":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":18,"centralContacts":19,"locations":18,"responsibleParty":25,"collaborators":18,"id":29,"slug":30,"hasResults":31,"nctId":32,"briefTitle":33,"officialTitle":34,"acronym":18,"eligibilityCriteria":35,"healthyVolunteers":31,"sex":36,"minAge":37,"maxAge":18,"enrollmentInfo":38,"targetDuration":18,"studyType":41,"phases":42,"briefSummary":44,"conditions":45,"keywords":18,"overallStatus":47,"whyStopped":18,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":18},{"fullName":5,"class":6},"Guangzhou Medical University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"cryoablation","EXPERIMENTAL","Lung cancer patients undergo treatment for peripheral malignant lung tumors using cryoablation technology under the guidance of bronchoscopy.",[13],"Procedure: cryoablation",[15],{"type":16,"name":9,"description":11,"armGroupLabels":17,"otherNames":18},"PROCEDURE",[9],null,[20],{"name":21,"role":22,"phone":23,"phoneExt":18,"email":24},"Changhao Zhong","CONTACT","020-81566640","vast1982@126.com",{"type":26,"investigatorFullName":27,"investigatorTitle":28,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Li Shiyue","Professor","100580105","a-clinical-study-of-the-cryoablation-technique-for-peripheral-lung-malignancies-100580105",false,"NCT06832969","A Clinical Study of the Cryoablation Technique for Peripheral Lung Malignancies","A Clinical Study on Verifying the Cryoablation Technique for Peripheral Lung Malignancies Under Bronchoscopy Guidance","Inclusion Criteria:\n\n* (1) Age ≥ 18 years, with no gender restrictions; (2) Diagnosed as having peripheral lung cancer, with the maximum diameter of the tumor being ≤ 3 cm and the number of tumors being ≤ 3; (3) The lesion intended for ablation is evaluated as feasible for bronchoscopy-guided cryoablation therapy; (4) The subject refuses or is deemed unsuitable for radiotherapy\u002Fchemotherapy, or has no response to previous radiotherapy\u002Fchemotherapy, or has disease progression after radiotherapy\u002Fchemotherapy; (5) Assessed as ineligible for surgery or refuses surgery and radiotherapy, consents to receive initial ablation treatment and signs the informed consent form.\n\nExclusion Criteria:\n\n* (1) Diffuse lesions in both lungs where ablation therapy fails to improve the condition; (2) Examinations within one month prior to the operation reveal the presence of hilar lymph node metastasis or extrapulmonary metastasis (except for cases where extrapulmonary metastasis has been controlled through local treatment); (3) Existence of contraindications for bronchoscopy, or inability of the patient to tolerate or cooperate with bronchoscopy; (4) Severe bleeding tendencies or uncorrectable coagulation dysfunctions (prothrombin time \\> 18 seconds, prothrombin activity \\\u003C 40%); (5) Platelet count \\\u003C 70×109\u002FL, or discontinuation of anticoagulant and\u002For antiplatelet drugs less than one week before ablation (except for the prophylactic use of low-molecular-weight heparin before the operation); (6) Severe impairment of lung function with a maximum ventilation volume \\\u003C 40%; (7) Concurrent presence of other tumors with extensive metastasis and an expected survival period of less than 3 months; (8) Poor overall condition (multiple metastases throughout the body, severe infection, high fever), infectious and radiation-induced inflammation around the lesion, obvious cachexia, severe dysfunction of important organs, severe anemia and short-term uncorrectable nutritional and metabolic disorders; (9) Eastern Cooperative Oncology Group (ECOG) performance status score \\> 2; (10) The lesion to be ablated has received radiotherapy within the past 6 months; (11) Active hepatitis B, active hepatitis C, human immunodeficiency virus (HIV) infection history (known positive for HIV1\u002F2 antibodies), or other active infections that are judged by the researcher to potentially affect the patient's treatment; (12) Accompanied by epilepsy, history of mental illness or cognitive impairment; (13) Pregnant or lactating women, as well as male or female patients who plan to have children or become pregnant during the trial; (14) Participation in any other clinical trials within 3 months before signing the informed consent (excluding non-interventional studies); (15) Other circumstances deemed by the researcher as inappropriate for participation in this clinical trial.","ALL","18 Years",{"count":39,"type":40},10,"ESTIMATED","INTERVENTIONAL",[43],"NA","To assess the safety and effectiveness of bronchoscopy-guided cryoablation with cold verification for peripheral lung malignancies.",[46],"Lung Cancer Patients","NOT_YET_RECRUITING","2025-02-12",{"date":50,"type":51},"2025-02-18","ACTUAL",{"date":53,"type":40},"2025-02-15",{"date":55,"type":40},"2025-12-31",{"name":5,"class":6}]