[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100609508":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":31,"responsibleParty":47,"collaborators":51,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":20,"eligibilityCriteria":61,"healthyVolunteers":58,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":20,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":75,"overallStatus":78,"whyStopped":20,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Peking University First Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"First-Line Treatment for MRD-Positive Patients Undergoing ASCT","EXPERIMENTAL","First-Line treatment with Dara-CyBorD achieves CR, but MRD-Positive patients are recommended to undergo ASCT.",[13],"Drug: First-Line Dara-BorCyD Treatment",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DRUG","First-Line Dara-BorCyD Treatment","First-Line Dara-BorCyD Treatment Achieves CR, but ASCT is Recommended for MRD-Positive Patients",[9],null,[22,27],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Yujun Dong","CONTACT","008618210264969","dongy@hsc.pku.edu.cn",{"name":28,"role":24,"phone":29,"phoneExt":20,"email":30},"Weiwei Xie","008617801203152","xieweiwei1227@163.com",[32],{"facility":5,"status":20,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Beijing","Beijing Municipality","100034","China","CN",{"type":39,"coordinates":40},"Point",[41,42],116.39723,39.9075,{"lat":42,"lon":41},[45],{"name":28,"role":24,"phone":46,"phoneExt":20,"email":30},"+8617801203152",{"type":48,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"PRINCIPAL_INVESTIGATOR","Yujun DONG","chief of department of hematology",[52,54],{"name":53,"class":6},"Beijing Chao Yang Hospital",{"name":55,"class":6},"Beijing Anzhen Hospital","100609508","a-clinical-study-on-minimal-residual-disease-in-patients-with-systemic-light-chain-amyloidosis-100609508",false,"NCT07215494","A Clinical Study on Minimal Residual Disease in Patients With Systemic Light Chain Amyloidosis","Inclusion Criteria:\n\n1. Age range: 18-70 years (inclusive), no gender restriction;\n2. Newly diagnosed AL amyloidosis patients;\n3. Meet ASCT eligibility criteria and have a willingness to undergo ASCT;\n4. Achieved hematological complete response (CR) after 2-4 cycles of Dara-CyBorD induction chemotherapy.\n\nExclusion Criteria:\n\n1. Secondary to multiple myeloma or lymphoplasmacytic lymphoma, such as Waldenström's macroglobulinemia;\n2. Co-existing other active malignant tumors;\n3. Co-existing other systemic diseases deemed unsuitable for inclusion by the investigator, such as newly developed severe cardiovascular and cerebrovascular diseases, or severe infections.","ALL","18 Years","70 Years",{"count":66,"type":67},50,"ESTIMATED","INTERVENTIONAL",[70],"NA","Before effective treatment, the prognosis of patients with AL amyloidosis is very poor, with a median survival of approximately 12 months. In recent decades, with the development of new drugs, the treatment paradigm for AL amyloidosis has undergone significant changes, and the prognosis has improved dramatically. Achieving very good partial response (VGPR) or even complete response (CR) can lead to higher organ response and longer survival. However, not all patients who achieve ≥VGPR reach organ response, which may be related to the presence of small residual plasma cell clones in these patients. The ongoing production of monoclonal light chains deposits into tissues and organs, causing continuous damage, making organ response difficult. With the development of new drugs, the rate of hematologic CR has continuously increased, and the advancement of minimal residual disease (MRD) detection technologies in recent years has led to increasing attention to MRD in AL amyloidosis research. Therefore, in this era of advancing new drugs, MRD negativity may become a higher clinical treatment goal for AL amyloidosis, further improving long-term prognosis for patients.\n\nOur department plans to conduct a single-center, prospective clinical study aimed at exploring the MRD status in patients who achieve hematologic CR after first-line induction chemotherapy (Dara-CyBorD), and further investigating whether autologous stem cell transplantation in MRD-positive CR patients who meet transplant criteria can further improve organ response, progression-free survival, and overall survival.",[73,74],"Light Chain (AL) Amyloidosis","MRD",[76,74,77],"light chain amyloidosis","ASCT","NOT_YET_RECRUITING","2025-10-02",{"date":81,"type":82},"2025-10-10","ACTUAL",{"date":84,"type":67},"2025-10",{"date":86,"type":67},"2029-09",{"name":5,"class":6},1]