[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100584636":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":26,"responsibleParty":37,"collaborators":26,"id":39,"slug":40,"hasResults":41,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":26,"eligibilityCriteria":45,"healthyVolunteers":46,"sex":47,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":26,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":26,"overallStatus":61,"whyStopped":26,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":26},{"fullName":5,"class":6},"Botanee Group Co., Ltd.","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Formulation containing MLYAAT-1002® Composition","ACTIVE_COMPARATOR","Before the Fotana4D Pro® treatment, daily use of the formulation containing MLYAAT-1002® for 14 days: apply one pump of the formulation to the test side of the face twice daily.",[13],"Combination Product: 14-day daily pre-operative application of the formulations containing MLYAAT-1002® before Fotona4D treatment",{"label":15,"type":16,"description":17,"interventionNames":18},"Blank formulation without MLYAAT-1002® Composition","PLACEBO_COMPARATOR","Before the Fotana4D Pro® treatment, daily use of the formulation without MLYAAT-1002® for 14 days: apply one pump of the formulation to the control side of the face twice daily.",[19],"Combination Product: 14-day daily pre-operative application of the formulations without MLYAAT-1002® before Fotona4D treatment",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"COMBINATION_PRODUCT","14-day daily pre-operative application of the formulations containing MLYAAT-1002® before Fotona4D treatment","All enrolled subjects will complete a 14-day washout period followed by a 14-day run-in phase prior to Fotona 4D® laser treatment. During the initial washout phase, participants will exclusively use basic skincare products: sunscreen, cleansing foam, and moisturizing emulsion. Then the subjects will apply the formulations containing MLYAAT-1002® of the active comparator to randomly assigned split-face (the treatment side) for the subsequent 14-day period. Following completion of the product application regimen, all participants will undergo a single session of Fotona 4D laser therapy.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"14-day daily pre-operative application of the formulations without MLYAAT-1002® before Fotona4D treatment","All enrolled subjects will complete a 14-day washout period followed by a 14-day run-in phase prior to Fotona 4D® laser treatment. During the initial washout phase, participants will exclusively use basic skincare products: sunscreen, cleansing foam, and moisturizing emulsion. Then the subjects will apply the formulations without MLYAAT-1002® of the placebo comparator to randomly assigned split-face (the control side) for the subsequent 14-day period. Following completion of the product application regimen, all participants will undergo a single session of Fotona 4D laser therapy.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Yihuai Liang","CONTACT","+86 13818831247","liangyihuai@botanee.com",{"type":38,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100584636","a-clinical-study-on-pre-operative-intervention-with-products-during-aesthetic-medicine-100584636",false,"NCT06891924","A Clinical Study on Pre-operative Intervention With Products During Aesthetic Medicine","Clinical Study on Pre-operative Intervention With Products to Mitigate Skin Discomfort During Aesthetic Medicine","Inclusion Criteria:\n\n* health females aged 35-60;\n* subjects with rough dark, loose fine lines;\n* no history of cosmetic allergies;\n* subjects are willing to use the test serum on split-face for 28 days;\n* subjects are willing to suffer the Fotona 4D treatment (Frac3 and Piano modes) on the face;\n* subjects are willing to use the basic skincare products for 28 days, and acceptable for split-face use of the test products or the control product for 14 days;\n* written informed consent and portrait right consent were obtained from all participants before study entry.\n\nExclusion Criteria:\n\n* anyone who is pregnant, nursing an infant, or planning a pregnancy during the study;\n* subjects with known allergies or sensitivities to the ingredients in any of the study products;\n* any symptoms of facial flushing, erythema, papules, desquamation, or edema as evaluated by a physician prior to initial screening or Fotona4D Pro treatment;\n* unhealed skin lesions;\n* participated in any other clinical trial within one month;\n* received facial skin treatments including but not limited to lasers, chemical peels, and dermal fillers within one month;\n* taken\u002Finjected anti-allergy medication in the past one month;\n* participants in other clinical trials at the same time;\n* any subjects that the investigator considers ineligible.",true,"FEMALE","35 Years","60 Years",{"count":51,"type":52},33,"ESTIMATED","INTERVENTIONAL",[55],"NA","This clinical trial aims to evaluate whether a 14-day pre-operative application of the test product (containing MLYAAT-1002®, a proprietary anti-aging complex) can mitigate skin discomfort during Fotona 4D laser therapy (Frac3 and Piano modes) by comparing clinical evaluation, skin attributes measurement and subject self-assessment.",[58,59,60],"Skin Aging","Skin Condition","Skin Manifestations","NOT_YET_RECRUITING","2025-03-26",{"date":64,"type":65},"2025-04-01","ACTUAL",{"date":67,"type":52},"2025-03-25",{"date":69,"type":52},"2025-06-01",{"name":5,"class":6}]