[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100620828":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":10,"centralContacts":22,"locations":28,"responsibleParty":45,"collaborators":10,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":10,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":10,"enrollmentInfo":58,"targetDuration":61,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":71,"overallStatus":31,"whyStopped":10,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Qianfoshan Hospital","OTHER",[8,13],{"label":9,"type":10,"description":10,"interventionNames":11},"Observation group: on the basis of the original standard drug treatment, combined with biological ag",null,[12],"Drug: Biologic Agent",{"label":14,"type":10,"description":15,"interventionNames":10},"The control group only received standard drug treatment (oral glucocorticoids with or without oral a","The standard medical regimen was oral prednisone (0.5mg\u002FKg\u002F day for 4 weeks, 0.25mg\u002FKg\u002F day for 4 weeks, followed by 0.125mg\u002FKg\u002F day for 4 weeks, followed by a reduction of 5mg every 2 weeks until discontinuation) with or without oral voriconazole (200mg bid, 1 hour before or after meals).",[17],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":10},"DRUG","Biologic Agent","On the basis of the original standard drug treatment, biological agents were combined. All patients received at least 4 months of the same biologic agent, as recommended by the GINA2025 guidelines and assessed for response. It can be administered simultaneously with standard medical therapy or as maintenance therapy for 4 months on standard medical therapy. The previous treatment for bronchial asthma was maintained, including inhaled corticosteroids + long-acting β-receptor agonists, leukotriene receptor antagonists, etc.",[9],[23],{"name":24,"role":25,"phone":26,"phoneExt":10,"email":27},"Qian Qi, Dr.","CONTACT","+86 13706380314","qiqianqlh@163.com",[29],{"facility":30,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Department of Respiratory, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, #16766, Jingshi Road, Jinan City, Shandong Province, China","RECRUITING","Jinan","Shandong","250014","China","CN",{"type":38,"coordinates":39},"Point",[40,41],116.99722,36.66833,{"lat":41,"lon":40},[44],{"name":24,"role":25,"phone":26,"phoneExt":10,"email":27},{"type":46,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Qian Qi","Prof.","100620828","a-cohort-study-of-the-efficacy-and-safety-of-biologics-in-patients-with-abpa-100620828",false,"NCT07362693","A Cohort Study of the Efficacy and Safety of Biologics in Patients With ABPA","A Prospective, Multicenter, Observational Cohort Study on the Efficacy and Safety of Biological Agents in Patients With Allergic Bronchopulmonary Aspergillosis","Inclusion Criteria:\n\n1. Meet the diagnostic criteria of allergic bronchopulmonary aspergillosis, according to the ISHAM guidelines for the diagnosis and treatment of allergic bronchopulmonary aspergillosis (2024 revision).\n2. The underlying disease was bronchial asthma, and it was severe bronchial asthma.\n3. Have had an acute asthma attack in the past year. Acute exacerbation of asthma is defined as the sudden onset of wheezing, shortness of breath, cough, chest tightness and other symptoms beyond the definition of uncontrolled asthma, or the aggravation of the original symptoms, and is characterized by decreased expiratory flow, often induced by exposure to allergens, irritants or respiratory tract infection.\n4. Blood eosinophil count ≥150 cells \u002FμL.\n5. Age ≥ 18 years old.\n\nExclusion Criteria:\n\n1. The underlying diseases were chronic obstructive pulmonary disease and bronchiectasis;\n2. Known allergic history to biological agents;\n3. Human immunodeficiency virus infection, active pulmonary tuberculosis or pulmonary malignant tumor;\n4. Complicated with other diseases requiring long-term systemic use of glucocorticoids or immunosuppressants (such as autoimmune diseases);\n5. Pregnant or lactating women;\n6. Currently participating in other interventional clinical research;\n7. Any other conditions considered by the investigator to preclude participation in the study (e.g., nonadherence, predicted survival \\\u003C1 year, or severe mental illness that prevented cooperation).","ALL","18 Years",{"count":59,"type":60},50,"ESTIMATED","2 Years","OBSERVATIONAL","To evaluate the efficacy and safety of biological agents in patients with allergic bronchopulmonary aspergillosis.",[65,66,67,68,69,70],"ABPA","Biologics","Allergic Bronchopulmonary Aspergillosis (ABPA)","Cohort Study","Allergic Bronchopulmonary Aspergillosis","Efficacy and Safety",[72,69,66],"abpa","2026-04-16",{"date":75,"type":76},"2026-04-17","ACTUAL",{"date":78,"type":76},"2025-01-31",{"date":80,"type":60},"2028-12-31",{"name":5,"class":6},1]