[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100536790":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":11,"centralContacts":11,"locations":37,"responsibleParty":57,"collaborators":59,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":64,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":11,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":88,"whyStopped":11,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"S.LAB (SOLOWAYS)","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention Group ibuprofen 400 and Curcumin","EXPERIMENTAL",null,[13],"Dietary Supplement: ibuprofen 400 mg in combination with Curcumin covered with liquorice root 100 mg",{"label":15,"type":10,"description":11,"interventionNames":16},"Intervention Group ibuprofen 200 and Curcumin",[17],"Dietary Supplement: ibuprofen 200 mg in combination with Curcumin covered with liquorice root 100 mg",{"label":19,"type":20,"description":11,"interventionNames":21},"Intervention Group ibuprofen 400 and placebo","PLACEBO_COMPARATOR",[22],"Other: The combination of ibuprofen 400 mg and placebo in patients after 2-4 molars procedure",[24,29,33],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"DIETARY_SUPPLEMENT","ibuprofen 400 mg in combination with Curcumin covered with liquorice root 100 mg","The combination of ibuprofen 400 mg and Curcumin covered with liquorice root 100 mg in patients after 2-4 molars procedure",[9],{"type":25,"name":30,"description":31,"armGroupLabels":32,"otherNames":11},"ibuprofen 200 mg in combination with Curcumin covered with liquorice root 100 mg","The combination of ibuprofen 200 mg and Curcumin covered with liquorice root 100 mg in patients after 2-4 molars procedure",[15],{"type":6,"name":34,"description":35,"armGroupLabels":36,"otherNames":11},"The combination of ibuprofen 400 mg and placebo in patients after 2-4 molars procedure","The combination of ibuprofen 400 mg and placebo 100 mg in patients after 2-4 molars procedure",[19],[38],{"facility":39,"status":11,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Nmsi Dentmaster","Novosibirsk","Novosibirsk Oblast","630090","Russia","RU",{"type":46,"coordinates":47},"Point",[48,49],82.93175,55.02259,{"lat":49,"lon":48},[52],{"name":53,"role":54,"phone":55,"phoneExt":56,"email":11},"Gatilova A Tatyana, MD","CONTACT","9529399919","+7",{"type":58,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR",[60],{"name":61,"class":6},"NMSI DENTMASTER","100536790","a-combination-of-ibuprofen-with-curcumin-covered-with-liquorice-root-supplementation-in-the-management-of-postoperative-dental-pain-in-adults-100536790",false,"NCT06269406","A Combination of Ibuprofen With Curcumin Covered With Liquorice Root Supplementation in the Management of Postoperative Dental Pain in Adults","A Combination of Ibuprofen With Curcumin Covered With Liquorice Root Supplementation in the Management of Postoperative Dental Pain in Adults, Randomized, Double- Blind, Parallel-Group, Placebo-Controlled Study","ICLID","Inclusion Criteria:\n\n* Removal of 2 to 4 impacted third molars\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding\n* Ibuprofen contraindications.\n* Allergy to any of the intervention components.","ALL","18 Years","85 Years",{"count":74,"type":75},264,"ESTIMATED","INTERVENTIONAL",[78],"NA","Dental pain, a common issue in stomatology, requires a multifaceted treatment approach. This study explores the efficacy of combining Ibuprofen with curcumin and liquorice root supplements for managing postoperative dental pain. Curcumin, known for its antioxidant and anti-inflammatory properties, along with liquorice root, may enhance pain relief beyond conventional NSAIDs like Ibuprofen. This randomized, double-blind, placebo-controlled trial aims to evaluate the safety and effectiveness of this combination therapy in adults undergoing the removal of impacted third molars. Participants, aged 18-85, were divided into groups receiving different doses of Ibuprofen and curcumin with liquorice root, compared to a control group receiving Ibuprofen and placebo. The primary outcome is the sum of pain intensity differences over 8 hours, with secondary outcomes including total pain relief and the occurrence of any adverse events. The anticipated sample size, considering a 20% dropout rate, is 264 participants, ensuring the study is powered to detect significant differences in pain management efficacy.",[81],"Dental Pain",[83,84,85,86,87],"Postoperative Dental Pain","Curcumin and Licorice Root","Ibuprofen","Anti-inflammatory Properties","molars","NOT_YET_RECRUITING","2025-06-06",{"date":91,"type":92},"2025-06-08","ACTUAL",{"date":94,"type":75},"2025-07-28",{"date":96,"type":75},"2025-09-28",{"name":5,"class":6},1]