[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643334":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":10,"responsibleParty":21,"collaborators":10,"id":25,"slug":26,"hasResults":27,"nctId":28,"briefTitle":29,"officialTitle":30,"acronym":31,"eligibilityCriteria":32,"healthyVolunteers":27,"sex":33,"minAge":34,"maxAge":35,"enrollmentInfo":36,"targetDuration":10,"studyType":39,"phases":10,"briefSummary":40,"conditions":41,"keywords":43,"overallStatus":47,"whyStopped":10,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":10},{"fullName":5,"class":6},"West China Hospital","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"delayed Endoscopic DTI Breast Reconstruction",null,"This technique, developed as an original procedure by our team, is performed through an axillary incision using a gas-inflated endoscopic approach. It breakthroughly integrates the traditional two-stage operation into a single-stage procedure. First, the retropectoral plane is dissected using a reverse-sequence technique. Postoperatively, intentional fluid accumulation within the implant pocket is utilized to expand the skin envelope. This achieves significantly greater tissue expansion compared to conventional tissue expanders, resulting in a reconstructed breast with a more natural contour and softer tissue consistency. Second, the entire procedure strategically avoids creating any new incisions within the breast region itself. This significantly reduces the risk of wound dehiscence and surgical site infection while shortening the postoperative recovery period.",{"label":13,"type":10,"description":14,"interventionNames":10},"delayed Autologous Flap Breast Reconstruction","·DIEP Flap (Deep Inferior Epigastric Perforator Flap) The DIEP flap uses skin and fat from the lower abdomen but preserves the rectus abdominis muscle. Only the tiny perforating blood vessels (deep inferior epigastric artery and vein) that pass through the muscle are dissected and taken with the flap. These vessels are then reconnected to vessels in the chest (usually internal mammary vessels) under a microscope.\n\nAdvantages: Minimal abdominal wall morbidity; lower risk of bulge or hernia; faster recovery of core strength.\n\n·TRAM Flap (Transverse Rectus Abdominis Myocutaneous Flap) The TRAM flap also uses lower abdominal tissue, but it includes a segment of the rectus abdominis muscle (either pedicled or free). In the pedicled version, the muscle with its overlying skin\u002Ffat is tunnelled under the skin up to the chest, relying on the superior epigastric vessels. In the free TRAM, the muscle is detached and reattached to chest vessels like a DIEP.",[16],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"Zhenggui Du","CONTACT","+86 13880768222","docduzg@163.com",{"type":22,"investigatorFullName":23,"investigatorTitle":24,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Du Zhenggui","deputy director","100643334","a-comparative-study-of-delayed-endoscopic-dti-and-autologous-flap-reconstruction-post-mastectomy-100643334",false,"NCT07602868","A Comparative Study of Delayed Endoscopic DTI and Autologous Flap Reconstruction Post-Mastectomy","A National Multicenter, Prospective, Cohort Study on Delayed Endoscopic Direct-to-Implant Breast Reconstruction Via Transaxillary Approach Versus Autologous Flap Breast Reconstruction Following Mastectomy","DEDIA","Inclusion Criteria:\n\n* Female patients aged 18-70 years\n* One year after Modified Radical Mastectomy (MRM), Nipple-Sparing Mastectomy (NSM), or Skin-Sparing Mastectomy (SSM), or six months after the completion of radiotherapy, provided the local skin remains viable and sufficiently lax;\n* voluntary participation and ability to provide written informed consent.\n\nExclusion Criteria:\n\n* History of breast surgery in which the pectoralis major muscle was removed;\n* Patients with serious preoperative co-morbidities and poor general condition who cannot tolerate the surgery;\n* Diabetes mellitus with a long history of smoking or combined poor glycemic control;\n* current enrollment in other clinical trials that may interfere with study outcomes;\n* Review (clinical, imaging, pathological basis) reveals the presence of local\u002Fregional recurrence or uncontrollable distant metastasis.","FEMALE","18 Years","70 Years",{"count":37,"type":38},588,"ESTIMATED","OBSERVATIONAL","In China, low breast-conserving surgery rates and historically minimal immediate reconstruction following mastectomy have resulted in a significant population of women living without a breast, often leading to long-term psychosocial distress. Current delayed reconstruction options are limited: traditional two-stage implant reconstruction necessitates two surgeries with associated costs and risks like infection and implant exposure, while autologous tissue transfer (e.g., TRAM\u002FDIEP flaps), though offering superior natural aesthetics and patient satisfaction, involves extensive donor-site morbidity, prolonged recovery, and significant scarring, restricting its suitability. To address the drawbacks of both established methods-significant trauma, cost, and complexity-this study evaluates a novel technique for breast cancer patients post-mastectomy: endoscopic delayed direct-to-implant breast reconstruction. This study proposes to conduct a prospective cohort study to analyze complication rates, breast aesthetic scores, quality of life metrics, and other dimensions between delayed direct-to-implant breast reconstruction and abdominal flap breast reconstruction（DIEP and TRAM). The aim is to comprehensively evaluate the safety and clinical feasibility of endoscopic delayed direct-to-implant breast reconstruction.",[42],"Breast Reconstruction After Mastectomy",[44,45,46],"delayed Endoscopic DTI","DIEP","TRAM","NOT_YET_RECRUITING","2026-06-08",{"date":50,"type":51},"2026-06-10","ACTUAL",{"date":53,"type":38},"2026-09-01",{"date":55,"type":38},"2030-12-31",{"name":5,"class":6}]