[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100610730":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":31,"centralContacts":32,"locations":31,"responsibleParty":40,"collaborators":44,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":50,"sex":56,"minAge":57,"maxAge":31,"enrollmentInfo":58,"targetDuration":31,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":68,"overallStatus":72,"whyStopped":31,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":31},{"fullName":5,"class":6},"Vanderbilt University Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Plunger Technique arm","ACTIVE_COMPARATOR","Participants randomized to this arm will undergo cyclic manual aspiration thrombectomy, also known as the Plunger Technique. This technique involves rhythmic, cyclic application of suction using FDA-approved devices: the Raptor Aspiration Catheter and VacLok Syringe, to remove thrombus in cases of acute ischemic stroke due to large vessel occlusion (terminal ICA or M1 segment of MCA).",[13],"Procedure: Plunger Technique",{"label":15,"type":10,"description":16,"interventionNames":17},"Manual Static Aspiration Arm","Participants randomized to this arm will undergo static manual aspiration thrombectomy, which involves continuous suction without modulation. The procedure will use FDA-approved devices: the Raptor Aspiration Catheter and VacLok Syringe, to remove thrombus in cases of acute ischemic stroke due to large vessel occlusion (terminal ICA or M1 segment of MCA).",[18],"Procedure: Static Manual Aspiration Thrombectomy",[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Plunger Technique","Rhythmic, cyclic application of suction using FDA-approved devices (Raptor Aspiration Catheter and VacLok Syringe) for clot removal in acute ischemic stroke.",[9],[26],"Cyclic Manual Aspiration Thrombectomy",{"type":21,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Static Manual Aspiration Thrombectomy","Continuous suction without modulation using FDA-approved devices (Raptor Aspiration Catheter and VacLok Syringe) for clot removal in acute ischemic stroke.",[15],null,[33,38],{"name":34,"role":35,"phone":36,"phoneExt":31,"email":37},"Michael T Froehler","CONTACT","6154210300","m.froehler@vumc.org",{"name":39,"role":35,"phone":31,"phoneExt":31,"email":31},"Tejeswini Siva Sathya",{"type":41,"investigatorFullName":42,"investigatorTitle":43,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"PRINCIPAL_INVESTIGATOR","Michael Froehler","Principle Investigator",[45],{"name":46,"class":47},"Balt USA","INDUSTRY","100610730","a-comparison-of-cyclic-manual-direct-aspiration-thrombectomy-plunger-technique-vs-static-manual-direct-aspiration-thrombectomy-for-treatment-of-acute-large-vessel-occlusion-stroke-100610730",false,"NCT07231380","A Comparison of Cyclic Manual Direct Aspiration Thrombectomy (Plunger Technique) vs. Static Manual Direct Aspiration Thrombectomy for Treatment of Acute Large Vessel Occlusion Stroke","Plunger Stroke Trial: A Comparison of Cyclic Manual Direct Aspiration Thrombectomy (Plunger Technique) vs. Static Manual Direct Aspiration Thrombectomy for Treatment of Acute Large Vessel Occlusion Stroke With the Raptor Aspiration Catheter","Plunger","Inclusion Criteria:\n\n\\- Acute ischemic stroke due to occlusion of the terminal ICA or M1 segment of the MCA, Treatment can be initiated within 24 hours of symptom onset, Age 18 years or older\n\nExclusion Criteria:\n\n* Evidence of acute intracranial hemorrhage prior to treatment, Failure to obtain informed consent","ALL","18 Years",{"count":59,"type":60},500,"ESTIMATED","INTERVENTIONAL",[63],"NA","This prospective, randomized controlled trial will compare two manual aspiration techniques for treating acute ischemic stroke due to large vessel occlusion: cyclic aspiration (Plunger technique) and static aspiration. Both techniques use FDA-approved devices (Raptor Aspiration Catheters and VacLok syringes) and are standard of care. Approximately 500 participants across 20 sites will be randomized to one of the two techniques. The primary endpoint is First Pass Effect (TICI 2c\u002F3 after first attempt), with secondary endpoints including overall recanalization and 90-day functional outcomes. Results will address a critical gap in optimizing aspiration thrombectomy techniques.",[66,67],"Acute Ischemic Stroke Patients","Large Vessel Occlusion",[69,67,70,22,71],"Acute Ischemic Stroke","Mechanical Aspiration Thrombectomy","Stroke Intervention","NOT_YET_RECRUITING","2026-05-15",{"date":75,"type":76},"2026-05-19","ACTUAL",{"date":78,"type":60},"2026-07-01",{"date":80,"type":60},"2027-06-01",{"name":5,"class":6}]