[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633182":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":30,"centralContacts":37,"locations":30,"responsibleParty":43,"collaborators":30,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":30,"eligibilityCriteria":53,"healthyVolunteers":49,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":30,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":30,"overallStatus":67,"whyStopped":30,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":30},{"fullName":5,"class":6},"Shaanxi Normal University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Pre-selected Trauma-related Cue Images with Eye Movement","EXPERIMENTAL","Participants assigned to this arm receive the eye-movement intervention with 8 pre-selected trauma-related cue images.",[13],"Behavioral: Pre-selected Trauma-related Cue Images with Eye Movement",{"label":15,"type":10,"description":16,"interventionNames":17},"Patient-provided Trauma-related Cue Images with Eye Movement","Participants assigned to this arm receive the eye-movement intervention with 4 personalized trauma-related cue images that they provided themselves. This arm serves as a high-specificity anchor condition for evaluating treatment effect magnitude, dropout, and acceptability.",[18],"Behavioral: Patient-provided Trauma-related Cue Images with Eye Movement",{"label":20,"type":21,"description":22,"interventionNames":23},"Neutral Images with Eye Movement","ACTIVE_COMPARATOR","Participants assigned to this arm receive the same eye-movement intervention with 8 neutral images unrelated to trauma. This arm is included to control for the general effects of visual stimulation and eye movements in the absence of trauma-related cue activation.",[24],"Behavioral: Neutral Images with Eye Movement",[26,31,34],{"type":27,"name":9,"description":28,"armGroupLabels":29,"otherNames":30},"BEHAVIORAL","After the baseline diary period, participants perform a continuous bilateral eye-movement task while being concurrently exposed to subliminally presented, masked pre-selected trauma-related cue images. This condition uses 8 pre-selected trauma-related cue images chosen by the research team to increase category-level cue coverage without requiring participants to provide their own trauma-related material.",[9],null,{"type":27,"name":15,"description":32,"armGroupLabels":33,"otherNames":30},"After the baseline diary period, participants provide 4 personalized trauma-related cue images. Participants then perform a continuous bilateral eye-movement task while being concurrently exposed to subliminally presented, masked personalized trauma-related cue images provided by themselves. This condition serves as a high-specificity anchor condition while reducing participant burden associated with providing larger numbers of trauma-related images.",[15],{"type":27,"name":20,"description":35,"armGroupLabels":36,"otherNames":30},"After the baseline diary period, participants perform the same continuous bilateral eye-movement task while being concurrently exposed to subliminally presented, masked pre-selected neutral images unrelated to trauma. This condition uses 8 neutral images and serves as an active control for the general effects of visual stimulation and eye movements while minimizing trauma-related cue activation.",[20],[38],{"name":39,"role":40,"phone":41,"phoneExt":30,"email":42},"Zijian Zhu","CONTACT","+86 13572494696","zhuzijian0203@snnu.edu.cn",{"type":44,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"SPONSOR_INVESTIGATOR","Zhu Zijian","Associate Professor","100633182","a-digital-cognitive-intervention-for-intrusive-memories-after-trauma-100633182",false,"NCT07523360","A Digital Cognitive Intervention for Intrusive Memories After Trauma","A Novel Digital Cognitive Intervention Targeting Intrusive Memories Among Trauma-Exposed Individuals: A Randomised Clinical Trial","Inclusion Criteria:\n\n1. Meet DSM-5 Criterion A for PTSD, which stipulates exposure to an event involving serious injury or a threat to one's own or another's physical well-being, either through direct experience or witnessing.\n2. Participants needed to exhibit symptoms from at least three of the five core PTSD symptom domains outlined in DSM-5: intrusive memories (Criterion B), persistent avoidance of trauma-related stimuli (Criterion C), negative alterations in cognitions and mood (Criterion D), alterations in arousal and reactivity (Criterion E), and symptoms lasting for at least one month (Criterion F).\n3. The total score of CAPS-5 ≥ 33.\n4. Have internet access and have access to a personal computer.\n5. Have not taken part in a previous study of this intervention from this research team.\n\nExclusion Criteria:\n\n1. Fewer than 5 intrusive memories during the baseline week (Week 0).\n2. IQ score lower than 80.\n3. A current diagnosis of schizophrenia, obsessive-compulsive disorder (OCD), a severe personality disorder judged to interfere with treatment adherence, or acute suicidal behavior.\n4. Have severe substance dependence.","ALL","18 Years","50 Years",{"count":58,"type":59},123,"ESTIMATED","INTERVENTIONAL",[62],"NA","Intrusive traumatic memories frequently trigger severe distress and psychological disorders like PTSD. Traditional therapies require explicit trauma recall, which often causes severe patient distress and leads to treatment avoidance. To address this, our study introduces a novel, less aversive intervention combining unconscious visual processing with bilateral eye movement to mitigate these intrusive memories.\n\nUtilizing a randomized, three-arm design (comparing standardized trauma-related images, patient-provided images, and neutral images, all paired with bilateral eye movements), we plan to recruit participants who have experienced severe trauma and report ≥ 5 intrusive memories weekly, targeting a final sample of 40 patients per arm. The primary outcome is the frequency of intrusive memories. Secondary and additional outcomes include PTSD severity (CAPS-5, PCL-5, IES), depression, anxiety, borderline symptoms, functional improvements, subjective intervention distress, and dropout rates.",[65,66],"Post-Traumatic Stress Disorder (PTSD)","Intrusive Memories of Traumatic Event(s)","NOT_YET_RECRUITING","2026-04-04",{"date":70,"type":71},"2026-04-13","ACTUAL",{"date":73,"type":59},"2026-04-10",{"date":75,"type":59},"2028-05-10",{"name":45,"class":6}]