[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100064634":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":29,"responsibleParty":50,"collaborators":10,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":10,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":10,"studyType":65,"phases":10,"briefSummary":66,"conditions":67,"keywords":70,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":10,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"National Institutes of Health Clinical Center (CC)","NIH",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Affected family members",null,"Family members with peripheral blood eosinophilia",{"label":13,"type":10,"description":14,"interventionNames":10},"Unaffected family members","Family members without peripheral blood eosinophilia",[16],{"name":17,"affiliation":18,"role":19},"Amy D Klion, M.D.","National Institute of Allergy and Infectious Diseases (NIAID)","PRINCIPAL_INVESTIGATOR",[21,26],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Thomas W Brown, R.N.","CONTACT","(301) 402-7823","browntw@mail.nih.gov",{"name":17,"role":23,"phone":27,"phoneExt":10,"email":28},"(240) 381-6073","amy.klion@nih.gov",[30],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"National Institutes of Health Clinical Center","RECRUITING","Bethesda","Maryland","20892","United States","US",{"type":39,"coordinates":40},"Point",[41,42],-77.10026,38.98067,{"lat":42,"lon":41},[45],{"name":46,"role":23,"phone":47,"phoneExt":48,"email":49},"For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)","800-411-1222","TTY dial 711","ccopr@nih.gov",{"type":51,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100064634","a-longitudinal-study-of-familial-hypereosinophilia-fe-natural-history-and-markers-of-disease-progression-100064634",false,"NCT00091871","A Longitudinal Study of Familial Hypereosinophilia (FE): Natural History and Markers of Disease Progression","* INCLUSION CRITERIA:\n\nIn order to be eligible to participate in this study, an individual must meet all of the following criteria:\n\n* Stated willingness to comply with all study procedures and availability for the duration of the study\n* Male or female, aged 1-100 years of age\n* Genetically related member of a previously identified family with FE\n* Ability of subject to understand and the willingness to sign a written informed consent document.\n\nEXCLUSION CRITERIA:\n\nAn individual who meets any of the following criteria will be excluded from participation in this study:\n\n* Any condition that the investigator feels put the subject at unacceptable risk for participation in the study\n* Pregnancy (in family members who do not have eosinophilia)",true,"ALL","1 Year","100 Years",{"count":63,"type":64},50,"ESTIMATED","OBSERVATIONAL","Eosinophils are a type of white blood cell. Elevated eosinophil levels can damage the heart, nerves, and other organs, in the syndrome known as hypereosinophilic syndrome (HES). Some individuals have a hereditary form of HES known as familial eosinophilia (FE). More research on the causation and mechanisms of HES is needed in order to design more effective and less toxic therapies.\n\nThis study will investigate FE and its genetic causes, damage mechanisms, and disease markers (such as blood test abnormalities). It will enroll approximately 50 individuals (both adults and children) from a previously studied family with FE. This is a long-term study of indefinite duration.\n\nParticipants will undergo yearly clinical examinations including medical history, physical examination, bloodwork, EKG, echocardiogram, and pulmonary function tests, with additional or more frequent examinations and tests as required. In addition, participants will donate blood and tissue for research purposes. Both adult and child participants will donate blood. At the initial evaluation, adult participants will donate bone marrow. During the study, some adult participants will also undergo a limited number of leukaopheresis sessions, in which blood is donated from one arm, the blood is separated into red blood cells and other components, and the red blood cells are returned into the donor's other arm.",[68,69],"Eosinophilia","Hypereosinophilic Syndrome",[71,72,73,74,75,76,77],"Hypereosinophilia","Eosinophil","Familial","Interleukin 5","Natural History","Familial Hypereosinophilia","FE","2026-05-06",{"date":80,"type":81},"2026-05-07","ACTUAL",{"date":83,"type":81},"2005-06-08",{"name":18,"class":6},1]