[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100592220":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":10,"locations":12,"responsibleParty":25,"collaborators":29,"id":34,"slug":35,"hasResults":36,"nctId":37,"briefTitle":38,"officialTitle":38,"acronym":10,"eligibilityCriteria":39,"healthyVolunteers":36,"sex":40,"minAge":41,"maxAge":42,"enrollmentInfo":43,"targetDuration":10,"studyType":46,"phases":10,"briefSummary":47,"conditions":48,"keywords":10,"overallStatus":50,"whyStopped":10,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":60},{"fullName":5,"class":6},"Beijing Tsinghua Chang Gung Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Cohort 1",null,"A total of 120 participants will be enrolled, with 40 receiving total knee arthroplasty (TKA) using a personalized prosthesis, 40 receiving semi-personalized TKA, and 40 receiving conventional TKA. Participants will be followed for one year post-surgery to assess clinical outcomes.",[13],{"facility":5,"status":10,"city":14,"state":15,"zip":16,"country":17,"countryCode":18,"cosmosGeoPoint":19,"geoPoint":24,"contacts":10},"Beijing","Beijing Municipality","102218","China","CN",{"type":20,"coordinates":21},"Point",[22,23],116.39723,39.9075,{"lat":23,"lon":22},{"type":26,"investigatorFullName":27,"investigatorTitle":28,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","YujiakuoTHU","Prof.",[30,32],{"name":31,"class":6},"Peking University Shougang Hospital",{"name":33,"class":6},"Beijing Chao Yang Hospital","100592220","a-multi-center-bidirectional-cohort-study-on-total-knee-arthroplasty-for-the-treatment-of-knee-osteoarthritis-100592220",false,"NCT06990594","A Multi-Center Bidirectional Cohort Study on Total Knee Arthroplasty for the Treatment of Knee Osteoarthritis","Inclusion Criteria:\n\n1. Patients aged 50-80 years.\n2. Diagnosed with end-stage knee osteoarthritis, post-traumatic arthritis, avascular necrosis, or inflammatory arthritis requiring total knee arthroplasty.\n3. Willing and able to provide informed consent.\n\nExclusion Criteria:\n\n1. History of prior knee surgery or knee replacement.\n2. Severe knee deformity (valgus \\>20° or varus \\>15°) or instability.\n3. Severe contracture (\\>25° flexion contracture).\n4. Undergoing total knee revision surgery.\n5. Rheumatoid arthritis diagnosis.\n6. BMI \\>35.\n7. Neuromuscular disorders affecting knee stability or gait.\n8. Pregnancy or lactation.\n9. Presence of significant comorbidities posing unacceptable risk.\n10. Active or recent severe infections or malignancy.\n11. History of drug or alcohol abuse in the past six months.","ALL","50 Years","80 Years",{"count":44,"type":45},120,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to evaluate the clinical benefits of different types of total knee arthroplasty (TKA) in osteoarthritis treatment. The study aims to compare surgical outcomes, functional recovery, complication rates, and cost-effectiveness among personalized, semi-personalized, and conventional TKA in a multi-center, bidirectional cohort study.",[49],"Osteoarthritis","NOT_YET_RECRUITING","2025-05-17",{"date":53,"type":54},"2025-05-25","ACTUAL",{"date":56,"type":45},"2025-06-01",{"date":58,"type":45},"2027-12-31",{"name":5,"class":6},1]