[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100507340":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":31,"centralContacts":32,"locations":41,"responsibleParty":60,"collaborators":31,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":31,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":31,"overallStatus":44,"whyStopped":31,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Zhejiang University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Structured Multi-domain Intervention","EXPERIMENTAL","Multi-domain structured intervention will be tailored by Chinese traditional and social norms and then conducted among the intervention group. That includes: Nutritional and dietary instruction, Cognitive training, Physical exercises, and Vascular risks monitoring and control.",[13],"Behavioral: Structured Multi-domain Intervention",{"label":15,"type":10,"description":16,"interventionNames":17},"Self-Guided Intervention","Every 6-12 months, control group will receive a regular health education campaign to encourage a healthy lifestyle and a regular health monitoring and examination of blood pressure, weight, fasting blood glucose and liposome group",[18],"Behavioral: Self-Guided Intervention",[20,26],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"BEHAVIORAL","Structured Multi-domain Intervention (SMI) involves providing participants with intensive structure and support by a team of trainers to increase physical exercise, adhere to a healthy diet, cognitive training, increase intellectual\u002Fsocial stimulation, and better manage vascular risk factors.",[9],[25],"SMI",{"type":21,"name":15,"description":27,"armGroupLabels":28,"otherNames":29},"In the Self-Guided Intervention (SGI), education about the importance of a healthy lifestyle as a preventive strategy and support to encourage change will be provided.",[15],[30],"SGI",null,[33,38],{"name":34,"role":35,"phone":36,"phoneExt":31,"email":37},"Xin Xu, PhD","CONTACT","+8613575760802","xuxinsummer@zju.edu.cn",{"name":39,"role":35,"phone":31,"phoneExt":31,"email":40},"Changzheng Yuan, PhD","chy478@zju.edu.cn",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"School of Public Health and The Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou, China","RECRUITING","Hangzhou","Zhejiang","310000","China","CN",{"type":51,"coordinates":52},"Point",[53,54],120.16142,30.29365,{"lat":54,"lon":53},[57],{"name":58,"role":35,"phone":31,"phoneExt":31,"email":59},"Xuhao Zhao, MPH","zhaoxuhao@zju.edu.cn",{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"PRINCIPAL_INVESTIGATOR","Xin Xu","Prof.","100507340","a-multi-domain-lifestyle-intervention-among-aged-community-residents-in-zhejiang-china-100507340",false,"NCT05886114","A Multi-domain Lifestyle Intervention Among Aged Community-residents in Zhejiang, China","HERITAGE","Inclusion Criteria:\n\n* At risk of cognitive decline: cognitive performance at the mean level or slightly lower than expected for age with no dementia (AD8\\>=3 and\u002For 5-min MoCA \\>, \\\u003C 11)\n* Free of physical disabilities that preclude participation in the study\n* Willing to complete all study-related activities for 24 months\n* Willing to be randomized to either lifestyle intervention group\n\nExclusion Criteria:\n\n* Diagnosed dementia patients\n* Diagnosed major depression or other neuropsychological diseases\n* Malignant diseases\n* Symptomatic cardiovascular disease\n* Revascularization within one year\n* Severe loss of vision, hearing or communicative ability",true,"ALL","60 Years","80 Years",{"count":76,"type":77},1200,"ESTIMATED","INTERVENTIONAL",[80],"NA","A study conducted in Finland discovered that a multidomain intervention, consisting of physical activity, nutritional guidance, cognitive training, social activities, and management of vascular risk factors, effectively decelerated cognitive decline in healthy older adults who were at an increased risk of cognitive decline. The HERITAGE study is a 2-year clustered randomized controlled trial (clustered-RCT) that explores the efficacy of a multidomain intervention among 1200 elderly residents with a higher risk of cognitive decline and dementia in Zhejiang Province, China",[83,84,85,86,87,88,89,90,91,92],"Cognitive Impairment","Alzheimer Disease","Vascular Cognitive Impairment","Dement","Brain Diseases","Central Nervous System Diseases","Nervous System Diseases","Neurocognitive Disorders","Mental Disorder","Cognition Disorder","2023-06-04",{"date":95,"type":96},"2023-06-06","ACTUAL",{"date":98,"type":77},"2023-05-28",{"date":100,"type":77},"2027-04-28",{"name":5,"class":6},1]