[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100547714":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":45,"centralContacts":49,"locations":54,"responsibleParty":70,"collaborators":73,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":79,"sex":84,"minAge":85,"maxAge":35,"enrollmentInfo":86,"targetDuration":35,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":35,"overallStatus":56,"whyStopped":35,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"University of Washington","OTHER",[8,14,19,24],{"label":9,"type":10,"description":11,"interventionNames":12},"SLEEP + COG","EXPERIMENTAL","* Combination of SLEEP and COG interventions, for up to 7 days\u002Fnights + usual post-ICU inpatient care\n* Personalized timing of morning, afternoon, or evening COG sessions, based on CSM scale at baseline",[13],"Behavioral: SLEEP + COG",{"label":15,"type":10,"description":16,"interventionNames":17},"COG","* Daily 30-minute computerized cognitive training sessions (Lumosity), for up to 7 days + usual post-ICU inpatient care\n* Personalized timing of morning, afternoon, or evening COG intervention sessions, based on CSM scale at baseline",[18],"Behavioral: COG",{"label":20,"type":10,"description":21,"interventionNames":22},"SLEEP","\\- Nighttime use of earplugs and eye masks, for up to 7 nights + usual post-ICU inpatient care",[23],"Behavioral: SLEEP",{"label":25,"type":26,"description":27,"interventionNames":28},"AC","ACTIVE_COMPARATOR","\\- Active comparator condition; delivery of educational modules on brain health + usual post-ICU inpatient care",[29],"Behavioral: AC",[31,36,39,42],{"type":32,"name":9,"description":33,"armGroupLabels":34,"otherNames":35},"BEHAVIORAL","Combination of SLEEP and COG interventions",[9],null,{"type":32,"name":15,"description":37,"armGroupLabels":38,"otherNames":35},"Daily 30-minute session of computerized cognitive training",[15],{"type":32,"name":20,"description":40,"armGroupLabels":41,"otherNames":35},"Nighttime use of both ear plugs and eye masks",[20],{"type":32,"name":25,"description":43,"armGroupLabels":44,"otherNames":35},"Educational modules on cognitive and sleep health",[25],[46],{"name":47,"affiliation":5,"role":48},"Maya N Elias, PhD, MA, RN","PRINCIPAL_INVESTIGATOR",[50],{"name":47,"role":51,"phone":52,"phoneExt":35,"email":53},"CONTACT","206-543-8564","mnelias@uw.edu",[55],{"facility":5,"status":56,"city":57,"state":58,"zip":59,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":68},"RECRUITING","Seattle","Washington","98195","United States","US",{"type":63,"coordinates":64},"Point",[65,66],-122.33207,47.60621,{"lat":66,"lon":65},[69],{"name":47,"role":51,"phone":35,"phoneExt":35,"email":53},{"type":48,"investigatorFullName":71,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":35,"oldOrganization":35},"Maya Elias, PhD, RN","Assistant Professor, School of Nursing",[74],{"name":75,"class":76},"National Institute on Aging (NIA)","NIH","100547714","a-multi-modal-combination-intervention-to-promote-cognitive-function-in-older-intensive-care-unit-survivors-100547714",false,"NCT06411561","A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors","SLEEP-COG","Inclusion Criteria:\n\n* Age greater than or equal to 60 years old\n* Current hospitalization at University of Washington Medical Center or Harborview Medical Center\n* Intensive care unit (ICU) length of stay greater than 24 hours\n* Recovery from critical care status to acute care status, and\u002For discharge out of ICU\n* Fluent in English or Spanish\n* Functional independence on activities of daily living prior to hospitalization (Katz Index = 6)\n\nExclusion Criteria:\n\n* Documented history or suspicion of Alzheimer's disease or dementia, or current prescription of anti-dementia medication\n* Documented history of bipolar disorder or schizophrenia\n* Documented acute stroke or traumatic brain injury\n* Severe vision impairment\n* Severe hearing impairment\n* Severe paralysis or dominant arm paresis\n* Transfer from skilled nursing care facility or inpatient rehabilitation facility","ALL","60 Years",{"count":87,"type":88},100,"ESTIMATED","INTERVENTIONAL",[91],"NA","Up to 25% of intensive care unit (ICU) survivors experience cognitive impairment comparable in severity to mild Alzheimer's disease and related dementias after hospital discharge. Older ICU survivors (ages 60 and older) are at highest risk for delirium and subsequent cognitive impairment, which contribute to higher risk for cognitive decline related to Alzheimer's disease and related dementias. Sleep and activity are essential for recovery from critical illness, yet ICU survivors experience both sleep deficiency and profound inactivity. About 75-80% of ICU patients experience circadian dysrhythmia, which contributes to cognitive decline and increases likelihood of developing Alzheimer's disease and related dementias. The scientific premises of the proposed study are: 1) a combined sleep promotion and cognitive training intervention will have synergistic effects to mitigate the risk of cognitive impairment and development of Alzheimer's disease and related dementias in older ICU survivors; and 2) chronotherapeutic timing of interventions (i.e., adjusting timing of interventions according to circadian rhythm) may improve intervention efficacy.",[94,95,96,97,98,99,100,101],"Critical Illness","Delirium","Cognitive Impairment","Cognitive Decline","Alzheimer's Disease","Dementia","Circadian Dysrhythmia","Sleep Disturbance","2025-07-16",{"date":104,"type":105},"2025-07-20","ACTUAL",{"date":107,"type":105},"2024-12-26",{"date":109,"type":88},"2027-05-31",{"name":5,"class":6},1]