[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621850":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":10,"locations":18,"responsibleParty":124,"collaborators":128,"id":136,"slug":137,"hasResults":138,"nctId":139,"briefTitle":140,"officialTitle":140,"acronym":10,"eligibilityCriteria":141,"healthyVolunteers":142,"sex":143,"minAge":144,"maxAge":145,"enrollmentInfo":146,"targetDuration":10,"studyType":149,"phases":10,"briefSummary":150,"conditions":151,"keywords":153,"overallStatus":157,"whyStopped":10,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":167},{"fullName":5,"class":6},"Shanghai Pulmonary Hospital, Shanghai, China","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"CT cohort",null,"Lung cancer patients or healthy individuals who can provide CT 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Hospital","Kunming","Yunnan","650100",{"type":27,"coordinates":115},[116,117],102.71833,25.03889,{"lat":117,"lon":116},[120],{"name":121,"role":35,"phone":122,"phoneExt":10,"email":123},"Xudong Xiang, M.D.","86-13108519813","xxd9813@163.com",{"type":125,"investigatorFullName":126,"investigatorTitle":127,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Chang Chen","Chief Physician",[129,130,131,132,133,134],{"name":99,"class":6},{"name":69,"class":6},{"name":39,"class":6},{"name":110,"class":6},{"name":20,"class":6},{"name":135,"class":6},"The First Hospital of Jilin University","100621850","a-multi-modal-integrating-imaging-and-cell-free-dna-methylation-in-lung-cancer-early-detection-cme-lung-a-multi-center-observational-study-100621850",false,"NCT07375979","A Multi-modal Integrating Imaging and Cell-free DNA Methylation in Lung Cancer Early Detection (CMe-Lung): a Multi-center, Observational Study","Inclusion Criteria:\n\n* 40-74 years old\n* Clinically and\u002For pathologically diagnosed cancer\n* No prior or undergoing any systemic or local antitumor therapy, including but not limited to surgical resection, radiochemotherapy, endocrinotherapy, targeted therapy, immunotherapy, interventional therapy, etc.\n* Able to provide a written informed consent and willing to comply with all part of the protocol procedures\n\nExclusion Criteria:\n\n* Pregnancy or lactating women\n* Known prior or current diagnosis of other types of malignancies comorbidities\n* Severe acute infection (e.g. severe or critical COVID-19, sepsis, etc.) or febrile illness (body temperature of ≥ 38.5 °C) within 14 days prior to screen\n* Recipients of organ transplant or prior bone marrow transplant or stem cell transplant\n* Recipients of blood transfusion within 30 days prior to screen\n* Recipients of therapy in past 14 days prior to screen, including oral or IV antibiotics, glucocorticoid, azacitidine, decitabine, procainamide, hydrazine, arsenic trioxide\n* Unsuitable for this trial determined by the researchers\n* Low-quality samples: images only partially showing the lungs or in lateral decubitus position, unreadable due to severe motion artifacts\u002Fmetal artifacts, or with missing critical metadata\n\nInclusion Criteria for Control Arm Participants:\n\n* 40-74 years old\n* Without confirmed cancer diagnosis\n* Able to provide a written informed consent and willing to comply with all part of the protocol procedures\n\nExclusion Criteria for Control Arm Participants:\n\n* Pregnancy or lactating women\n* Known prior or current diagnosis of other types of malignancies comorbidities\n* Severe acute infection (e.g. severe or critical COVID-19, sepsis, etc.) or febrile illness (body temperature of ≥ 38.5 °C) within 14 days prior to screen\n* Recipients of organ transplant or prior bone marrow transplant or stem cell transplant\n* Recipients of blood transfusion within 30 days prior to screen\n* Recipients of therapy in the past 14 days prior to screen, including oral or IV antibiotics, glucocorticoid, azacitidine, decitabine, procainamide, hydrazine, arsenic trioxide\n* Unsuitable for this trial determined by the researchers\n* Low-quality samples: images only partially showing the lungs or in lateral decubitus position, unreadable due to severe motion artifacts\u002Fmetal artifacts, or with missing critical metadata",true,"ALL","40 Years","74 Years",{"count":147,"type":148},14300,"ESTIMATED","OBSERVATIONAL","This study is a multi-center, observational study aiming to develop an early screening multi-model for detecting lung cancer signals through the integration of imaging (non-contrast CT) and blood testing (cfDNA methylation).",[152],"Lung Cancer",[154,155,156],"multi-modal","CT and cfDNA methylation","lung cancer early detection","NOT_YET_RECRUITING","2026-01-21",{"date":160,"type":161},"2026-01-29","ACTUAL",{"date":163,"type":148},"2026-02-05",{"date":165,"type":148},"2026-09-01",{"name":5,"class":6},7]