[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100536995":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":12,"locations":7,"responsibleParty":17,"collaborators":19,"id":28,"slug":29,"hasResults":30,"nctId":31,"briefTitle":32,"officialTitle":32,"acronym":7,"eligibilityCriteria":33,"healthyVolunteers":30,"sex":34,"minAge":35,"maxAge":36,"enrollmentInfo":37,"targetDuration":7,"studyType":40,"phases":7,"briefSummary":41,"conditions":42,"keywords":44,"overallStatus":48,"whyStopped":7,"lastUpdateSubmitDate":49,"lastUpdatePostDateStruct":50,"startDateStruct":53,"completionDateStruct":55,"leadSponsor":57,"locationsCount":7},{"fullName":5,"class":6},"Zhejiang University","OTHER",null,[9],{"name":10,"affiliation":5,"role":11},"Jiajia Chen","PRINCIPAL_INVESTIGATOR",[13],{"name":10,"role":14,"phone":15,"phoneExt":7,"email":16},"CONTACT","+8615967109232","Jiajiatale0@zju.edu.cn",{"type":11,"investigatorFullName":10,"investigatorTitle":18,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Chief Physician of the First Affiliated Hospital,Zhejiang University School of Medicine",[20,22,24,26],{"name":21,"class":6},"Beijing Ditan Hospital",{"name":23,"class":6},"Beijing YouAn Hospital",{"name":25,"class":6},"Huashan Hospital",{"name":27,"class":6},"Qilu Hospital of Shandong University","100536995","a-multicenter-prospective-clinical-cohort-study-on-the-pathogen-spectrum-of-severe-hepatitis-liver-failure-complicated-with-infection-100536995",false,"NCT06272071","A Multicenter Prospective Clinical Cohort Study on the Pathogen Spectrum of Severe Hepatitis (Liver Failure) Complicated With Infection","Inclusion Criteria:\n\n1. Patients agreed to participate in the study and signed an informed consent form;\n2. Sex is not limited and age is 18-70 years old;\n3. HBsAg positive for more than 6 months, or hepatitis E IgM positive, or hepatitis E RNA positive;\n4. Progressive deepening of jaundice in a short period of time (serum total bilirubin greater than 10 times the upper limit of normal or rising ≥17.1 umol\u002FL per day);\n5. Sgnificant bleeding tendency with PTA ≤ 40% and exclusion of other non-hepatic factors.\n\nExclusion Criteria:\n\n1. Patients with severe hepatitis caused by other non-hepatophilic viral infections;\n2. Patients who were considered by the investigator to be unsuitable for participation in the study.","ALL","18 Years","70 Years",{"count":38,"type":39},2000,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to expound the population and characteristics of pathogenic microorganisms with co-infection, draw the pedigree of pathogenic microorganisms, and evaluate its influence on disease outcome in patients with severe hepatitis (liver failure). The main questions it aims to answer are:\n\n* Mapping of infectious agents in patients with severe hepatitis (liver failure)\n* Constructing early warning predictive models to explore how to give an individualized regimen of integrated immune function.",[43],"Liver Failure",[45,46,47],"Severe hepatitis","Pathogen pedigree of infection","cohort study","NOT_YET_RECRUITING","2024-03-01",{"date":51,"type":52},"2024-03-04","ACTUAL",{"date":54,"type":39},"2024-03",{"date":56,"type":39},"2026-11",{"name":5,"class":6}]