[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100596827":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":41,"responsibleParty":127,"collaborators":26,"id":129,"slug":130,"hasResults":131,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":26,"eligibilityCriteria":135,"healthyVolunteers":131,"sex":136,"minAge":137,"maxAge":138,"enrollmentInfo":139,"targetDuration":26,"studyType":142,"phases":143,"briefSummary":145,"conditions":146,"keywords":150,"overallStatus":44,"whyStopped":26,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":161},{"fullName":5,"class":6},"The First Affiliated Hospital with Nanjing Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Constant (5%) oxygen concentration protocols in embryo culture","PLACEBO_COMPARATOR","Patients randomly assigned to use constant (5%) oxygen concentration protocols in embryo culture",[13],"Procedure: Constant oxygen concentration protocols in embryo culture",{"label":15,"type":16,"description":17,"interventionNames":18},"Sequential (5%-2%) oxygen concentration protocols in embryo culture","EXPERIMENTAL","Patients randomly assigned to use Sequential (5%-2%) oxygen concentration protocols in embryo culture",[19],"Procedure: Sequential oxygen concentration protocols in embryo culture",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Constant oxygen concentration protocols in embryo culture","Participants were randomly assigned to constant (5%) oxygen concentration group and received different blastocyst culture protocols.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Sequential oxygen concentration protocols in embryo culture","Participants were randomly assigned to sequential (5%-2%) oxygen concentration group and received different blastocyst culture protocols.",[15],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Xiang Ma","CONTACT","+86 18001581878","sxmaxiang@126.com",{"name":38,"role":34,"phone":39,"phoneExt":26,"email":40},"Haofeng Wang","+86 18018387209","haofengwang@stu.njmu.edu.cn",[42,61,76,90,99,112],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"The Third Affiliated Hospital of Zhengzhou University","RECRUITING","Zhengzhou","Henan","450000","China","CN",{"type":51,"coordinates":52},"Point",[53,54],113.64861,34.75778,{"lat":54,"lon":53},[57],{"name":58,"role":34,"phone":59,"phoneExt":26,"email":60},"Binnan Ren, MD","+86 13253619382","moking_rbn@163.com",{"facility":62,"status":44,"city":63,"state":64,"zip":65,"country":48,"countryCode":49,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"Changzhou Maternal And Child Health Care Hospital","Changzhou","Jiangsu","213000",{"type":51,"coordinates":67},[68,69],119.95401,31.77359,{"lat":69,"lon":68},[72],{"name":73,"role":34,"phone":74,"phoneExt":26,"email":75},"Xiyang Xia, MD","+86 13861266074","xiaxiyang900711@163.com",{"facility":77,"status":44,"city":78,"state":64,"zip":79,"country":48,"countryCode":49,"cosmosGeoPoint":80,"geoPoint":84,"contacts":85},"Nanjing Women and Children's Healthcare Hospital","Nanjing","210000",{"type":51,"coordinates":81},[82,83],118.77778,32.06167,{"lat":83,"lon":82},[86],{"name":87,"role":34,"phone":88,"phoneExt":26,"email":89},"Mengqian Chen, MD","+86 15105183515","imchenmx@163.com",{"facility":91,"status":44,"city":78,"state":64,"zip":26,"country":48,"countryCode":49,"cosmosGeoPoint":92,"geoPoint":94,"contacts":95},"Reproductive Medicine of First Affiliated Hospital with Nanjing Medical University",{"type":51,"coordinates":93},[82,83],{"lat":83,"lon":82},[96,98],{"name":97,"role":34,"phone":35,"phoneExt":26,"email":36},"Xiang Ma, MD. PHD",{"name":38,"role":34,"phone":39,"phoneExt":26,"email":40},{"facility":100,"status":44,"city":101,"state":64,"zip":26,"country":48,"countryCode":49,"cosmosGeoPoint":102,"geoPoint":106,"contacts":107},"Suzhou Municipal Hospital","Suzhou",{"type":51,"coordinates":103},[104,105],120.59538,31.30408,{"lat":105,"lon":104},[108],{"name":109,"role":34,"phone":110,"phoneExt":26,"email":111},"Aiyan Zheng, MD","+86 18662180810","36663735@qq.com",{"facility":113,"status":44,"city":114,"state":115,"zip":116,"country":48,"countryCode":49,"cosmosGeoPoint":117,"geoPoint":121,"contacts":122},"Northwest Women's and Children's Hospital","Xi’an","Shanxi","710000",{"type":51,"coordinates":118},[119,120],113.52486,35.99785,{"lat":120,"lon":119},[123],{"name":124,"role":34,"phone":125,"phoneExt":26,"email":126},"Tingting He","18392161661","1016760162@qq.com",{"type":128,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100596827","a-multicenter-prospective-randomized-controlled-clinical-trial-comparing-constant-5-versus-sequential-5-2-oxygen-concentration-embryo-culture-protocols-in-assisted-reproductive-technology-100596827",false,"NCT07050537","A Multicenter Prospective Randomized Controlled Clinical Trial Comparing Constant (5%) Versus Sequential (5%-2%) Oxygen Concentration Embryo Culture Protocols in Assisted Reproductive Technology","A Multicenter Prospective Randomized Controlled Clinical Trial Comparing Constant (5%) Versus Sequential (5%-2%) Oxygen Concentration Embryo Culture Protocols in Assisted Reproductive Technology: Evaluating Term Live Birth and Offspring Health Outcomes","Inclusion Criteria:\n\n1. Female: age ≥20 and ≤40 years, male: age ≥20 and ≤50 years;\n2. Proposed 1st or 2nd cycle of IVF or ICSI fertilization;\n3. ≥ 4 transferable embryos at oocyte stage.\n\nExclusion Criteria:\n\n1. Diagnosis of abnormal uterine cavity morphology (confirmed by 3D ultrasound or hysteroscopy), including uterine malformations (mediastinal uterus, unicornuate uterus, bicornuate uterus), submucosal uterine fibroids, or uterine adhesions;\n2. Patients who are proposed to undergo IVM;\n3. Patients who are proposed to undergo PGD\u002F PGS;\n4. Patients with untreated severe hydrosalpinx (confirmed by ultrasound or HSG);\n5. Patients with a history of recurrent miscarriage (2 or more previous pregnancy losses, excluding biochemical pregnancies);\n6. Patients who plan to freeze whole embryos and are unable to complete a single embryo transfer within six months;\n7. Patients with contraindications to assisted reproductive technology and pregnancy, or suffering from diseases that have a definite effect on pregnancy: including uncontrolled hypertension, heart disease with definite symptoms, uncontrolled diabetes, undefined diagnosis of liver or kidney disease or liver or kidney insufficiency, severe anemia, history of previous venous thrombosis, pulmonary embolism or cerebrovascular events, history of malignant tumors, suspected malignant tumors, and undiagnosed abnormal uterine bleeding.","FEMALE","20 Years","40 Years",{"count":140,"type":141},980,"ESTIMATED","INTERVENTIONAL",[144],"NA","To evaluate whether there were significant differences in the effects of constant (5%) versus sequential (5%-2%) oxygen concentration protocols in embryo culture on term live birth rates.\n\nThis study will be conducted in five centers including the Clinical Center of Reproductive Medicine, First Affiliated Hospital of Nanjing Medical Universit. 980 women who wish to undergo blastocyst transplantation will be included in the study.\n\nThe study data will be analyzed statistically.",[147,148,149],"Fertility Issues","Blastocyst IVF","Embryo Culture",[148,151],"Fertility","2026-05-29",{"date":154,"type":155},"2026-06-01","ACTUAL",{"date":157,"type":155},"2025-03-01",{"date":159,"type":141},"2027-08-31",{"name":5,"class":6},6]