[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100615460":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":24,"centralContacts":28,"locations":33,"responsibleParty":302,"collaborators":10,"id":305,"slug":306,"hasResults":307,"nctId":308,"briefTitle":309,"officialTitle":309,"acronym":10,"eligibilityCriteria":310,"healthyVolunteers":311,"sex":312,"minAge":313,"maxAge":314,"enrollmentInfo":315,"targetDuration":10,"studyType":318,"phases":10,"briefSummary":319,"conditions":320,"keywords":326,"overallStatus":330,"whyStopped":10,"lastUpdateSubmitDate":331,"lastUpdatePostDateStruct":332,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":339,"locationsCount":340},{"fullName":5,"class":6},"First Hospital of China Medical University","OTHER",[8,12,15,18,21],{"label":9,"type":10,"description":11,"interventionNames":10},"Healthy Adults Group",null,"Healthy adults aged 18 to 79 years are planned to be stratified into 6 age groups: 18-29 years, 30-39 years, 40-49 years, 50-59 years, 60-69 years, and ≥70 years. Each age group will include 120 participants of each sex.",{"label":13,"type":10,"description":14,"interventionNames":10},"Pulmonary Hypertension Group","This group comprises adults with a confirmed diagnosis of mean pulmonary artery pressure (mPAP) ≥20 mmHg via right heart catheterization, in accordance with the diagnostic criteria for pulmonary hypertension specified in the 2022 ESC\u002FERS Guidelines.",{"label":16,"type":10,"description":17,"interventionNames":10},"Tricuspid Regurgitation Group","Adults with moderate or severe primary\u002Fsecondary tricuspid regurgitation confirmed by echocardiography.",{"label":19,"type":10,"description":20,"interventionNames":10},"Atrial Septal Defect Group","Adults with atrial septal defect confirmed by echocardiography or transesophageal echocardiography, including non-intervened patients, those who underwent closure\u002Fsurgical correction, and stable patients \\> 3 months after surgery.",{"label":22,"type":10,"description":23,"interventionNames":10},"Heart Failure Group","Adults meeting the 2022 AHA\u002FACC\u002FHFSA diagnostic criteria for heart failure are classified into three subgroups based on left ventricular ejection fraction (LVEF): heart failure with reduced ejection fraction (HFrEF, LVEF \\\u003C 40%), heart failure with mildly reduced ejection fraction (HFmrEF, LVEF 40-49%), and heart failure with preserved ejection fraction (HFpEF, LVEF ≥ 50%).",[25],{"name":26,"affiliation":5,"role":27},"Chunyan Ma, MD","PRINCIPAL_INVESTIGATOR",[29],{"name":26,"role":30,"phone":31,"phoneExt":10,"email":32},"CONTACT","+86 13998816448","mcy_echo@163.com",[34,49,58,70,78,90,98,110,119,130,142,154,162,173,184,195,206,219,231,242,251,263,272,283,294],{"facility":35,"status":10,"city":36,"state":37,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Chongqing Liangjiang New Area Hospital of Traditional Chinese Medicine","Chongqing","Chongqing Municipality","China","CN",{"type":41,"coordinates":42},"Point",[43,44],106.55771,29.56026,{"lat":44,"lon":43},[47],{"name":48,"role":30,"phone":10,"phoneExt":10,"email":10},"Yan Zhang",{"facility":50,"status":10,"city":51,"state":52,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":53,"geoPoint":57,"contacts":10},"Shenzhen People's Hospital","Shenzhen","Guangdong",{"type":41,"coordinates":54},[55,56],114.0683,22.54554,{"lat":56,"lon":55},{"facility":59,"status":10,"city":60,"state":61,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":62,"geoPoint":66,"contacts":67},"Shijiazhuang People's Hospital","Shijiazhuang","Hebei",{"type":41,"coordinates":63},[64,65],114.47861,38.04139,{"lat":65,"lon":64},[68],{"name":69,"role":30,"phone":10,"phoneExt":10,"email":10},"Xiaoqing Yang",{"facility":71,"status":10,"city":60,"state":61,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":72,"geoPoint":74,"contacts":75},"The Third Affiliated Hospital of Hebei Medical University",{"type":41,"coordinates":73},[64,65],{"lat":65,"lon":64},[76],{"name":77,"role":30,"phone":10,"phoneExt":10,"email":10},"Heping Deng",{"facility":79,"status":10,"city":80,"state":81,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":82,"geoPoint":86,"contacts":87},"The First Affiliated Hospital of Harbin Medical University","Harbin","Heilongjiang",{"type":41,"coordinates":83},[84,85],126.65,45.75,{"lat":85,"lon":84},[88],{"name":89,"role":30,"phone":10,"phoneExt":10,"email":10},"Hui Liu",{"facility":91,"status":10,"city":80,"state":81,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":92,"geoPoint":94,"contacts":95},"The Fourth Affiliated Hospital of Harbin Medical University",{"type":41,"coordinates":93},[84,85],{"lat":85,"lon":84},[96],{"name":97,"role":30,"phone":10,"phoneExt":10,"email":10},"Tianle Yu",{"facility":99,"status":10,"city":100,"state":101,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":102,"geoPoint":106,"contacts":107},"Henan Provincial People's Hospital","Zhengzhou","Henan",{"type":41,"coordinates":103},[104,105],113.64861,34.75778,{"lat":105,"lon":104},[108],{"name":109,"role":30,"phone":10,"phoneExt":10,"email":10},"Haohui Zhu, PhD",{"facility":111,"status":10,"city":112,"state":113,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":114,"geoPoint":118,"contacts":10},"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","Wuhan","Hubei",{"type":41,"coordinates":115},[116,117],114.26667,30.58333,{"lat":117,"lon":116},{"facility":120,"status":10,"city":121,"state":113,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":122,"geoPoint":126,"contacts":127},"Xiangyang No.1 Peoples Hospital","Xiangyang",{"type":41,"coordinates":123},[124,125],112.14479,32.0422,{"lat":125,"lon":124},[128],{"name":129,"role":30,"phone":10,"phoneExt":10,"email":10},"Yu Wang, Ph.D",{"facility":131,"status":10,"city":132,"state":133,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":134,"geoPoint":138,"contacts":139},"The Second Affiliated Hospital of Jilin University","Changchun","Jilin",{"type":41,"coordinates":135},[136,137],125.32278,43.88,{"lat":137,"lon":136},[140],{"name":141,"role":30,"phone":10,"phoneExt":10,"email":10},"Dongmei Lv",{"facility":143,"status":10,"city":144,"state":145,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":146,"geoPoint":150,"contacts":151},"Anshan Central Hospital","Anshan","Liaoning",{"type":41,"coordinates":147},[148,149],122.99,41.12361,{"lat":149,"lon":148},[152],{"name":153,"role":30,"phone":10,"phoneExt":10,"email":10},"Yao Wang",{"facility":155,"status":10,"city":144,"state":145,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":156,"geoPoint":158,"contacts":159},"Ansteel Group General Hospita",{"type":41,"coordinates":157},[148,149],{"lat":149,"lon":148},[160],{"name":161,"role":30,"phone":10,"phoneExt":10,"email":10},"Gang Du, Ph.D",{"facility":163,"status":10,"city":164,"state":145,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":165,"geoPoint":169,"contacts":170},"Chaoyang Central Hospital","Chaoyang",{"type":41,"coordinates":166},[167,168],120.45861,41.57028,{"lat":168,"lon":167},[171],{"name":172,"role":30,"phone":10,"phoneExt":10,"email":10},"Hong Zhou",{"facility":174,"status":10,"city":175,"state":145,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":176,"geoPoint":180,"contacts":181},"the Second Hospital of Dalian Medical University","Dalian",{"type":41,"coordinates":177},[178,179],121.60222,38.91222,{"lat":179,"lon":178},[182],{"name":183,"role":30,"phone":10,"phoneExt":10,"email":10},"Jun Wu",{"facility":185,"status":10,"city":186,"state":145,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":187,"geoPoint":191,"contacts":192},"Huludao Second People's Hospital","Huludao",{"type":41,"coordinates":188},[189,190],120.83552,40.75243,{"lat":190,"lon":189},[193],{"name":194,"role":30,"phone":10,"phoneExt":10,"email":10},"Xuan Wang",{"facility":196,"status":10,"city":197,"state":145,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":198,"geoPoint":202,"contacts":203},"Liaohua Hospital","Liaoyang",{"type":41,"coordinates":199},[200,201],123.17306,41.27194,{"lat":201,"lon":200},[204],{"name":205,"role":30,"phone":10,"phoneExt":10,"email":10},"Shuangyan Liu",{"facility":207,"status":10,"city":208,"state":145,"zip":209,"country":38,"countryCode":39,"cosmosGeoPoint":210,"geoPoint":214,"contacts":215},"The First Hospital of China Medical University","Shenyang","110000",{"type":41,"coordinates":211},[212,213],123.43278,41.79222,{"lat":213,"lon":212},[216,218],{"name":26,"role":30,"phone":217,"phoneExt":10,"email":32},"+8613998816448",{"name":26,"role":30,"phone":10,"phoneExt":10,"email":10},{"facility":220,"status":10,"city":221,"state":222,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":223,"geoPoint":227,"contacts":228},"The First Affiliated Hospital of Xi'an Jiaotong University","Xi'an","Shaanxi",{"type":41,"coordinates":224},[225,226],108.92861,34.25833,{"lat":226,"lon":225},[229],{"name":230,"role":30,"phone":10,"phoneExt":10,"email":10},"Shun Wang",{"facility":232,"status":10,"city":233,"state":222,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":234,"geoPoint":238,"contacts":239},"The Second Affiliated Hospital of Shaanxi University of Chinese Medicine","Xianyang",{"type":41,"coordinates":235},[236,237],108.70261,34.33778,{"lat":237,"lon":236},[240],{"name":241,"role":30,"phone":10,"phoneExt":10,"email":10},"Xiaoli Zhu",{"facility":243,"status":10,"city":244,"state":245,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":246,"geoPoint":250,"contacts":10},"The Affiliated Hospital of Qingdao University","Qingdao","Shandong",{"type":41,"coordinates":247},[248,249],120.38042,36.06488,{"lat":249,"lon":248},{"facility":252,"status":10,"city":253,"state":254,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":255,"geoPoint":259,"contacts":260},"Shanxi Provincial People's Hospital","Taiyuan","Shanxi",{"type":41,"coordinates":256},[257,258],112.56028,37.86944,{"lat":258,"lon":257},[261],{"name":262,"role":30,"phone":10,"phoneExt":10,"email":10},"Weiqing Li",{"facility":264,"status":10,"city":265,"state":266,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":267,"geoPoint":271,"contacts":10},"West China Hospital，Sichuan University","Chengdu","Sichuan",{"type":41,"coordinates":268},[269,270],104.06667,30.66667,{"lat":270,"lon":269},{"facility":273,"status":10,"city":274,"state":10,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":275,"geoPoint":279,"contacts":280},"Beijing Chaoyang Hospital, Capital Medical University","Beijing",{"type":41,"coordinates":276},[277,278],116.39723,39.9075,{"lat":278,"lon":277},[281],{"name":282,"role":30,"phone":10,"phoneExt":10,"email":10},"Yidan Li",{"facility":284,"status":10,"city":285,"state":10,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":286,"geoPoint":290,"contacts":291},"Shanghai Chest Hospital","Shanghai",{"type":41,"coordinates":287},[288,289],121.45806,31.22222,{"lat":289,"lon":288},[292],{"name":293,"role":30,"phone":10,"phoneExt":10,"email":10},"fan li",{"facility":295,"status":10,"city":285,"state":10,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":296,"geoPoint":298,"contacts":299},"Zhongshan Hospital, Fudan University, Shanghai",{"type":41,"coordinates":297},[288,289],{"lat":289,"lon":288},[300],{"name":301,"role":30,"phone":10,"phoneExt":10,"email":10},"Xianhong Shu",{"type":27,"investigatorFullName":303,"investigatorTitle":304,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Chunyan Ma","Chief of Cardiovascular Ultrasound","100615460","a-multicenter-study-on-the-normal-reference-range-and-clinical-significance-of-the-right-atrioventricular-coupling-index-assessed-by-artificial-intelligence-based-three-dimensional-echocardiography-100615460",false,"NCT07292896","A Multicenter Study on the Normal Reference Range and Clinical Significance of the Right Atrioventricular Coupling Index Assessed by Artificial Intelligence-Based Three-Dimensional Echocardiography","Healthy Adults Group\n\nInclusion Criteria:\n\n* Participants must meet all of the following criteria to be enrolled:\n\n  1. Of Han Chinese ethnicity\n  2. Aged 18-79 years\n  3. Normal blood pressure (\\\u003C 140\u002F90 mmHg)\n  4. Normal fasting blood glucose\n  5. Normal blood lipid levels (triglycerides, total cholesterol, low-density lipoprotein, high-density lipoprotein)\n  6. Normal complete blood count results (hemoglobin concentration, white blood cell count, red blood cell count, platelet count)\n  7. Normal liver and renal function (alanine transaminase \\\u003C 2× upper limit of normal; normal creatinine and blood urea nitrogen)\n  8. Normal electrocardiogram results (occasional atrial premature beats may be enrolled at the investigator's discretion)\n  9. No structural heart disease and normal cardiac function confirmed by echocardiography\n\nExclusion Criteria:\n\nParticipants will be excluded if they meet any of the following criteria:\n\n1. Clinically significant cardiac valve regurgitation (≥ mild severity)\n2. Respiratory diseases: acute or chronic respiratory disorders\n3. Endocrine diseases: thyroid disease, diabetes mellitus, hyperaldosteronism, pheochromocytoma, etc.\n4. Abnormal liver function (alanine transaminase \\> 2× upper limit of normal), abnormal renal function (elevated creatinine beyond normal range), or dyslipidemia (elevated triglycerides, total cholesterol, low-density lipoprotein, or high-density lipoprotein)\n5. Other systemic diseases: anemia, malignancy, connective tissue disease, large artery\u002Fperipheral vascular diseases (aortic dilation, aortic dissection, coarctation of the aorta, Takayasu arteritis, atherosclerosis), etc.\n6. Pregnant or lactating women\n7. Professional athletes\n8. Poor-quality ultrasound images that cannot support parameter measurement and analysis\n\nPulmonary Hypertension Group\n\nInclusion Criteria:\n\nPatients must meet all of the following criteria to be enrolled:\n\n1. Aged 18-79 years\n2. Confirmed diagnosis via right heart catheterization: mean pulmonary arterial pressure (mPAP) ≥ 20 mmHg, in accordance with the 2022 ESC\u002FERS guidelines\n\nExclusion Criteria:\n\nPatients will be excluded if they meet any of the following criteria:\n\n1. Unable to complete right heart catheterization or pressure-volume loop assessment\n2. Complicated with significant left heart disease (left ventricular ejection fraction \\[LVEF\\] \\\u003C 50%, significant mitral valve disease)\n3. Pericardial disease or arrhythmias (e.g., atrial fibrillation) that severely impair right heart function evaluation\n4. Poor-quality images that prevent accurate measurement of right atrial or right ventricular parameters\n5. Concurrent liver or renal disease\n6. Concurrent malignancy\n7. History of surgical procedures such as pulmonary endarterectomy or balloon pulmonary angioplasty\n\nHeart Failure Group\n\nInclusion Criteria:\n\nPatients must meet all of the following criteria to be enrolled:\n\n1. Aged 18-79 years\n2. Meets the 2022 AHA\u002FACC\u002FHFSA diagnostic criteria for heart failure\n\nExclusion Criteria:\n\nPatients will be excluded if they meet any of the following criteria:\n\n1.Complicated with significant valvular heart disease (e.g., severe mitral regurgitation, severe tricuspid regurgitation, etc.)\n\nTricuspid Regurgitation Group\n\nInclusion Criteria:\n\nPatients must meet all of the following criteria to be enrolled:\n\n1. Moderate or severe primary or secondary tricuspid regurgitation confirmed by echocardiography\n2. Aged 18-79 years\n\nExclusion Criteria:\n\nPatients will be excluded if they meet any of the following criteria:\n\n1. Pericardial disease or arrhythmias (persistent atrial fibrillation) that interfere with measurements\n2. Congenital heart disease or residual lesions after surgical correction\n\nAtrial Septal Defect Group\n\nInclusion Criteria:\n\nPatients must meet all of the following criteria to be enrolled:\n\n1. Secundum atrial septal defect confirmed by echocardiography or transesophageal echocardiography\n2. Patients who have not undergone closure or surgical correction, or stable patients with \\> 3 months postoperatively\n3. Aged 18-79 years\n\nExclusion Criteria:\n\n1.Complicated with other complex congenital heart diseases.",true,"ALL","18 Years","79 Years",{"count":316,"type":317},2640,"ESTIMATED","OBSERVATIONAL","This multicenter study aims to establish the normal reference range of the Right Atrioventricular Coupling Index (RACI) in healthy Chinese adults using AI-based 3DE technology. It will also analyze the correlation between RACI and physiological parameters such as age, gender, and body surface area. Additionally, the study will explore the variation characteristics of RACI in patients with pulmonary hypertension, heart failure, tricuspid regurgitation, and atrial septal defect, and evaluate the clinical value of RACI in disease diagnosis, differential diagnosis, and risk stratification.",[321,322,323,324,325],"Healthy Adults","Pulmonary Hypertension","Tricuspid Regurgitation","Heart Failure","Atrial Septal Defect",[327,328,329],"Right Atrioventricular Coupling Index","3D Echocardiography","AI-assisted Imaging","NOT_YET_RECRUITING","2025-12-06",{"date":333,"type":334},"2025-12-18","ACTUAL",{"date":336,"type":317},"2025-12",{"date":338,"type":317},"2026-12",{"name":5,"class":6},25]