[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100420472":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":17,"locations":26,"responsibleParty":45,"collaborators":10,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":10,"eligibilityCriteria":52,"healthyVolunteers":49,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":10,"studyType":59,"phases":10,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":29,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"National Institutes of Health Clinical Center (CC)","NIH",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Cohort 1",null,"Subjects with confirmed olfactory neuroblastoma.",[13],{"name":14,"affiliation":15,"role":16},"Charalampos Floudas, M.D.","National Cancer Institute (NCI)","PRINCIPAL_INVESTIGATOR",[18,23],{"name":19,"role":20,"phone":21,"phoneExt":10,"email":22},"Marissa B Mallek, R.N.","CONTACT","(240) 760-7498","marissa.mallek@nih.gov",{"name":14,"role":20,"phone":24,"phoneExt":10,"email":25},"(240) 474-1575","charalampos.floudas@nih.gov",[27],{"facility":28,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"National Institutes of Health Clinical Center","RECRUITING","Bethesda","Maryland","20892","United States","US",{"type":36,"coordinates":37},"Point",[38,39],-77.10026,38.98067,{"lat":39,"lon":38},[42],{"name":43,"role":20,"phone":44,"phoneExt":10,"email":10},"For more information at the NIH Clinical Center contact National Cancer Institute Referral Office","888-624-1937",{"type":46,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100420472","a-natural-history-study-of-children-and-adults-with-olfactory-neuroblastoma-100420472",false,"NCT04755205","A Natural History Study of Children and Adults With Olfactory Neuroblastoma","* INCLUSION CRITERIA:.\n* Subjects with histologically documented olfactory neuroblastoma.\n* Age \\>= 3 years old.\n* Ability of subject to understand and the willingness to sign a written consent document\n\nEXCLUSION CRITERIA:\n\nPregnant women are excluded from this study because of more than minimal risk activities (imaging studies with contrast, biopsies) pertaining to enrollment.","ALL","3 Years","120 Years",{"count":57,"type":58},525,"ESTIMATED","OBSERVATIONAL","Background:\n\nOlfactory neuroblastoma (ONB) is a rare cancer. It grows from tissue in the upper part of the nose cavity, related to the sense of smell and can affect a person s sense of smell. Researchers want to better understand the health problems of people with ONB. This may help them design better treatment and supportive care studies.\n\nObjective:\n\nTo better understand ONB-the course of the disease, tumor characteristics, response to treatments, and management of the treatment.\n\nEligibility:\n\nPeople ages 3 years and older who have ONB. They must enroll in NIH studies #19-C-0016 and #18-DC-0051.\n\nDesign:\n\nParticipants will be screened with a medical history and medical record review.\n\nParticipants do not have to visit NIH.\n\nParticipants will give a blood sample. They will complete surveys to assess their emotional and physical wellbeing and needs. Leftover tissue from biopsies and surgeries will be collected.\n\nParticipants will take smell tests. They will smell items and answer questions about them.\n\nParticipants may take taste tests. They will get plastic taste strips that they will move around their mouth to determine the taste.\n\nParticipants may have a physical exam. Their performance status may be assessed.\n\nParticipants may give blood, saliva, urine, and nasal secretion samples.\n\nParticipants may have computed tomography and\u002For magnetic resonance imaging scans.\n\nParticipants may have one or more tumor biopsies.\n\nParticipants will talk to the research team about the results of their medical record\u002Ftests evaluation. The team will recommend how to best manage and treat their disease.\n\nParticipants may give samples and complete surveys every 12 months. Their medical records will be reviewed every year. They will be monitored for the rest of their life.",[62,63],"Olfactory Neuroblastoma","Esthesioneuroblastoma",[65,66,67,68,69],"esthesioneuroblastoma","nasal cavity tumor","pediatric onb","adult onb","Natural History","2026-06-27",{"date":72,"type":73},"2026-06-30","ACTUAL",{"date":75,"type":73},"2022-06-02",{"date":77,"type":58},"2029-12-31",{"name":15,"class":6},1]