[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100557987":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":26,"collaborators":10,"id":30,"slug":31,"hasResults":32,"nctId":33,"briefTitle":34,"officialTitle":34,"acronym":10,"eligibilityCriteria":35,"healthyVolunteers":36,"sex":37,"minAge":38,"maxAge":10,"enrollmentInfo":39,"targetDuration":10,"studyType":42,"phases":10,"briefSummary":43,"conditions":44,"keywords":10,"overallStatus":46,"whyStopped":10,"lastUpdateSubmitDate":47,"lastUpdatePostDateStruct":48,"startDateStruct":51,"completionDateStruct":53,"leadSponsor":55,"locationsCount":10},{"fullName":5,"class":6},"IRCCS Ospedale San Raffaele","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"USH2A-RP",null,"Patients affected by genetically-confirmed USH2A-RP.",[13],"Diagnostic Test: microRNAs analysis",{"label":15,"type":10,"description":16,"interventionNames":17},"controls","Healthy control subjects",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DIAGNOSTIC_TEST","microRNAs analysis","Patients will undergo routinary ophthalmological examination, multimodal retinal imaging and blood sampling",[9,15],[25],"multimodal retinal imaging",{"type":27,"investigatorFullName":28,"investigatorTitle":29,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Maria Lucia Cascavilla","Co-Principal Investigator","100557987","a-new-diagnostic-paradigm-for-retinitis-pigmentosa-secondary-to-ush2a-pathogenic-variants-100557987",false,"NCT06545253","A New Diagnostic Paradigm for Retinitis Pigmentosa Secondary to USH2A Pathogenic Variants","Inclusion Criteria:\n\n* age \\>18 years\n* genetically confirmed diagnosis of USH2A-RP\n* availability of genetic tests to assess the pathogenic variants\n\nExclusion Criteria:\n\n* inability to understand and sign the written informed consent form\n* any inflammatory, infectious or degenerative eye disease\n* media opacities resulting incompatible with good imaging quality\n* uncontrolled systemic, metabolic, autoimmune neuroinflammatory and neurodegenerative disease\n* ophthalmologic surgery within the previous six months",true,"ALL","18 Years",{"count":40,"type":41},60,"ESTIMATED","OBSERVATIONAL","Aim of the study is to perform a non-invasive multimodal retinal imaging investigation in a cohort of patients affected by USH2A retinitis pigmentosa (USH2A-RP), in order to develop a new diagnostic paradigm to categorize clinically relevant subgroups. All the procedures will be performed according to normal clinical practice. In addition, a novel quantitative profiling of serum microRNAs will be carried out in order to analyze the clinical importance of microRNA biomarkers in the clinical setting of the disease.",[45],"USH2A Variant Retinitis Pigmentosa","NOT_YET_RECRUITING","2024-08-06",{"date":49,"type":50},"2024-08-09","ACTUAL",{"date":52,"type":41},"2024-08",{"date":54,"type":41},"2027-02",{"name":5,"class":6}]