[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623380":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":21,"centralContacts":30,"locations":37,"responsibleParty":52,"collaborators":21,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":21,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":21,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":21,"overallStatus":76,"whyStopped":21,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Aalborg University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Active group","EXPERIMENTAL","Heath will be applied prior pruritogens application",[13,14,15],"Other: Cowhage (Mucuna Pruriens)","Other: Histamine","Other: Heat",[17,22,26],{"type":6,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"Cowhage (Mucuna Pruriens)","The spicules will be manually inserted. Approximately 30-35 spicules are gently rubbed into a 1 cm diameter skin area on the forearm\u002Fface",[9],null,{"type":6,"name":23,"description":24,"armGroupLabels":25,"otherNames":21},"Histamine","To deliver histamine, standard allergy skin prick test (SPT) lancets are applied",[9],{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":21},"Heat","45 °C x 5 min",[9],[31],{"name":32,"role":33,"phone":34,"phoneExt":35,"email":36},"Silvia Lo Vecchio, PhD","CONTACT","21397785","0045","slv@hst.aau.dk",[38],{"facility":39,"status":21,"city":40,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Center for Neuroplasticity and Pain Faculty of Medicine, Aalborg University Selma Lagerløfs Vej 249 9260 Gistrup, Denmark","Aalborg","9620","Denmark","DK",{"type":45,"coordinates":46},"Point",[47,48],9.9187,57.048,{"lat":48,"lon":47},[51],{"name":32,"role":33,"phone":34,"phoneExt":35,"email":36},{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":21,"oldOrganization":21},"PRINCIPAL_INVESTIGATOR","Silvia Lo Vecchio","Associate Professor","100623380","a-new-model-to-induce-itch-and-inflammation-100623380",false,"NCT07395882","A New Model to Induce Itch and Inflammation","Investigating the Neurophysiology of Itch","Inclusion Criteria:\n\n* Healthy men and women\n* 18-60 years\n* Speak and understand English\n\nExclusion Criteria:\n\n* Pregnancy or lactation\n* Drug addiction defined as any use of cannabis, opioids, or other addictive drugs\n* Previous or current history of neurological (e.g., neuropathy), immunological (e.g., asthma, immune deficiencies, arthritis), musculoskeletal (e.g., muscular pain in the upper extremities), cardiac disorder (e.g., stroke), or psychiatric diagnoses (e.g., depression, bipolar disorders, acute and chronic psychosis) that may affect the results\n* Current use of medications that may affect the trial, such as antihistamines, antipsychotics, painkillers, and systemic or topical steroids\n* Skin diseases (e.g., atopic dermatitis, pruritus nodularis, eczema, psoriasis)\n* Moles, scars, or tattoos in the area to be treated or tested (forearm\u002Fhand).\n* Consumption of alcohol or painkillers 24 hours before the study days and between these\n* Acute or chronic pain\n* Unable to answer the \"Transcranial Magnetic Stimulation Adult Safety Screen\" (subprojects 2-4)\n* Contraindications to transcranial magnetic stimulation (TMS) application (history of epilepsy, metal implants in head or jaw, etc.) (subprojects 2-4)\n* Presence of implanted hearing aids or metal implants on the face, including permanent makeup or tattoos (subprojects 2-4)\n* Contraindications to capsaicin, including intolerance to chili or burns or wounds at the application sites (subprojects 2, 3, and 4)\n* Participation in other trials within one week of study entry (four weeks in the case of pharmaceutical trials)\n* The subject is assessed as unable to engage in the necessary cooperation required by the study",true,"ALL","18 Years","60 Years",{"count":68,"type":69},28,"ESTIMATED","INTERVENTIONAL",[72],"NA","This project aims to create a reliable, long-lasting itch model by synergistically combining thermal pre-conditioning with the application of histamine or cowhage.",[75],"Itching","NOT_YET_RECRUITING","2026-02-09",{"date":79,"type":80},"2026-02-11","ACTUAL",{"date":82,"type":69},"2026-02-15",{"date":84,"type":69},"2029-12-31",{"name":5,"class":6},1]