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Non-interventional Study for Kisqali (Ribociclib) in Combination With an Aromatase Inhibitor for Adjuvant Treatment in Patients With HR+\u002FHER2- Early Breast Cancer at High Risk of Recurrence","A Non-interventional Study for Kisqali (Ribociclib) in Combination With an Aromatase Inhibitor for Adjuvant Treatment in Patients With HR+\u002FHER2- Early Breast Cancer at High Risk of Recurrence to Evaluate Real-world Effectiveness, Safety Profile, Patient Compliance and Quality of Life","CAROLEEN","Inclusion Criteria:\n\n* Histological diagnosis of HR+\u002FHER2- early breast cancer with curative intent\n* Patients must have an indication for a treatment with ribociclib + AI ± LHRH as described in the current SmPC\u002F\"Fachinformation\" of ribociclib (to be included into the cohorts of ribociclib + AI ± LHRH and ET mono ± LHRH) or abemaciclib + ET ± LHRH as described in the current SmPC\u002F\"Fachinformation\" of abemaciclib (to be included into the abemaciclib + ET ± LHRH cohort) in the adjuvant setting\n* Before enrollment the treating physician has made the decision in accordance with the patient to treat the patient with either\n\n  * ribociclib + AI ± LHRH, or\n  * ET mono ± LHRH, or\n  * abemaciclib + ET ± LHRH and baseline is no longer than 2 weeks (14 days) prior to written informed consent for this study.\n\nBaseline = for ribociclib + AI ± LHRH cohort: date of therapy start; for abemaciclib + ET ± LHRH cohort: date of therapy start; for ET mono ± LHRH cohort: within 4 weeks after therapy start or within 4 weeks after last non-endocrine based therapy, whichever is last.\n\n* ≥18 years of age\n* Written informed consent\n\nExclusion Criteria:\n\n\\- Patient is simultaneously participating in any investigational trial or simultaneously participating in another Novartis-sponsored non-interventional study with ribociclib.","ALL","18 Years","100 Years",{"count":2121,"type":2122},3250,"ESTIMATED","OBSERVATIONAL","This non-interventional observational study evaluates the real-world effectiveness and safety profile of ribociclib in combination with an aromatase inhibitor for adjuvant treatment in patients with HR+\u002FHER2- early breast cancer at high risk of recurrence, as well as patient compliance and quality of life.",[2126],"Breast Neoplasms",[2128,2129,2130,2131,2132,2133,9,2134,2135],"Non-interventional study","NIS","breast cancer","early breast cancer","HR+","HER-","real world evidence","adjuvant therapy","2026-05-28",{"date":2138,"type":2139},"2026-06-01","ACTUAL",{"date":2141,"type":2139},"2025-02-20",{"date":2143,"type":2122},"2030-06-30",{"name":37,"class":6},283]