[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100581888":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":28,"responsibleParty":51,"collaborators":54,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":58,"sex":64,"minAge":65,"maxAge":10,"enrollmentInfo":66,"targetDuration":10,"studyType":69,"phases":10,"briefSummary":70,"conditions":71,"keywords":80,"overallStatus":31,"whyStopped":10,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Fraser Health","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"DEP",null,"Participants with suspected, new-onset, or established depression presenting to the psychiatric outpatient clinic at Royal Columbian Hospital.",{"label":13,"type":10,"description":14,"interventionNames":10},"PSY","Participants experiencing a first episode of psychosis or established schizophrenia presenting to an outpatient psychosis clinic at Royal Columbian Hospital.",[16],{"name":17,"affiliation":18,"role":19},"Steven Reynolds, MD, FRCPC","Royal Columbian Hospital Foundation","PRINCIPAL_INVESTIGATOR",[21,26],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Jessica Wittmann","CONTACT","+1 (236) 332-6575","LeadingMH@fraserhealth.ca",{"name":27,"role":23,"phone":24,"phoneExt":10,"email":25},"Marlena Ornowska",[29],{"facility":30,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Royal Columbian Hospital","RECRUITING","New Westminster","British Columbia","V3L 3M2","Canada","CA",{"type":38,"coordinates":39},"Point",[40,41],-122.91092,49.20678,{"lat":41,"lon":40},[44,45,46,49],{"name":22,"role":23,"phone":10,"phoneExt":10,"email":25},{"name":17,"role":19,"phone":10,"phoneExt":10,"email":10},{"name":47,"role":48,"phone":10,"phoneExt":10,"email":10},"Elizabeth Rohrs, PhD, RRT","SUB_INVESTIGATOR",{"name":50,"role":48,"phone":10,"phoneExt":10,"email":10},"Siri Reinbold, MD, FRCPC",{"type":19,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Steve Reynolds","Intensivist, MD, FRCPC",[55],{"name":18,"class":6},"100581888","a-novel-blood-test-as-a-biomarker-in-mental-health-100581888",false,"NCT06856161","A Novel Blood Test as a Biomarker in Mental Health","A Novel Blood Test as a Differential Diagnosis and Drug Efficacy Biomarker in Mental Health","LEADING-MH","Inclusion Criteria:\n\nI. Age 19+. II. Informed consent by participant\n\nIII. Any of the following situations:\n\n1. Suspected, new onset or established depression.\n2. First episode of psychosis or suspected\u002Festablished schizophrenia. IV. In the opinion of the Investigator, the participant will likely be able to complete the standardized mental health questionnaires administered in each study visit.\n\nExclusion Criteria:\n\nI. Inability to provide informed consent. II. Currently enrolled in any other research study involving drugs or devices that may confound mental health treatment outcomes.\n\nIII. Currently declared on extended leave Under British Columbia's Mental Health Act.","ALL","19 Years",{"count":67,"type":68},500,"ESTIMATED","OBSERVATIONAL","This longitudinal, observational study aims to assess whether the characteristics of a novel blood peripheral biomarker can serve as indicators for depression and schizophrenia in patients at the Royal Columbian Hospital Psychiatric Clinics. The study will evaluate whether changes in these biomarker characteristics can help distinguish between depressed patients who do or do not respond to treatment and between individuals experiencing a single psychotic episode and those at risk of progressing to schizophrenia. To achieve this, blood samples and standardized mental health assessments will be collected across three study visits from up to 500 participants, grouped into two study arms based on their diagnosis: Depression (DEP) or Psychosis\u002FSchizophrenia (PSY).",[72,73,74,75,76,77,78,79],"Depression - Major Depressive Disorder","Schizophenia Disorder","Psychosis","Mania (Neurotic)","Alcohol Consumption","Anxiety Disorder (Panic Disorder or GAD)","Substance Use Disorders","Alcohol Use Disorder",[81,82,83,84,85,86],"mental health","biomarker","depression","schizophrenia","psychosis","SERT","2026-03-03",{"date":89,"type":90},"2026-03-05","ACTUAL",{"date":92,"type":90},"2025-03-25",{"date":94,"type":68},"2027-08-31",{"name":5,"class":6},1]