[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628911":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":11,"centralContacts":11,"locations":11,"responsibleParty":25,"collaborators":29,"id":34,"slug":35,"hasResults":36,"nctId":37,"briefTitle":38,"officialTitle":38,"acronym":11,"eligibilityCriteria":39,"healthyVolunteers":36,"sex":40,"minAge":41,"maxAge":11,"enrollmentInfo":42,"targetDuration":11,"studyType":45,"phases":46,"briefSummary":48,"conditions":49,"keywords":11,"overallStatus":51,"whyStopped":11,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":53,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":11},{"fullName":5,"class":6},"The George Institute","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental group","EXPERIMENTAL",null,[13],"Device: Low-intensity pulsed ultrasound",{"label":15,"type":16,"description":11,"interventionNames":11},"Control group","NO_INTERVENTION",[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"DEVICE","Low-intensity pulsed ultrasound","During periods of stable blood pressure, administer cervical ultrasound stimulation (3-minute stimulation followed by a 2-minute interval, repeated cyclically; total stimulation duration not exceeding 60 minutes).",[9],[24],"LIPUS",{"type":26,"investigatorFullName":27,"investigatorTitle":28,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"SPONSOR_INVESTIGATOR","Tao Liu","investigator",[30,32],{"name":31,"class":6},"Tianjin Medical University General Hospital",{"name":33,"class":6},"Xuanwu Hospital, Beijing","100628911","a-proof-of-concept-study-of-ultrasound-stimulation-of-the-neck-to-enhance-anti-shock-efficacy-100628911",false,"NCT07467798","A Proof-of-concept Study of Ultrasound Stimulation of the Neck to Enhance Anti-shock Efficacy","Inclusion Criteria:\n\n* Patients with shock who are ≥18 years of age and have a systolic blood pressure (SBP) between 60 mmHg and 90 mmHg;\n* Patients with arterial blood pressure monitoring or peripheral arterial pressure monitoring with intervals of single-digit minutes;\n* Patients with mild to moderate shock with a shock index (SI) of 1 ≤ SI ≤ 2;\n* Patients with complete medical records.\n\nExclusion Criteria:\n\n* Patients with unstable condition and estimated survival time \\\u003C24 hours;\n* Patients requiring emergency surgery to achieve control of their condition;\n* Perioperative patients requiring surgery due to conditions other than hypotension;\n* Pregnant or lactating patients;\n* Patients with neck wounds and\u002For carotid artery plaques who are unsuitable for ultrasound stimulation of the left carotid sinus;\n* Patients deemed unsuitable for inclusion by the investigator.","ALL","18 Years",{"count":43,"type":44},30,"ESTIMATED","INTERVENTIONAL",[47],"NA","The objective of this clinical study is to evaluate the initial efficacy and safety of LIPUS as an adjunct to standard therapy in patients with shock. The investigators will invite patients to participate in a proof-of-concept study investigating the efficacy of neck ultrasound stimulation to enhance anti-shock treatment, involving brief exposure to low-intensity pulsed ultrasound. This study examines whether LIPUS can enhance blood pressure in patients with shock, improve the efficacy of antihypotensive treatment, and reduce the dosage and duration of vasoactive drugs during active pharmacological therapy. By applying LIPUS as an adjunct to conventional treatment in clinical cases of shock, we aim to determine the clinical value of LIPUS and establish a theoretical foundation for developing innovative new therapies for shock.",[50],"Shock","NOT_YET_RECRUITING","2026-04-17",{"date":54,"type":55},"2026-04-22","ACTUAL",{"date":57,"type":44},"2026-05",{"date":59,"type":44},"2027-11",{"name":27,"class":6}]