[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100346956":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":22,"centralContacts":27,"locations":38,"responsibleParty":58,"collaborators":10,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":64,"sex":69,"minAge":70,"maxAge":10,"enrollmentInfo":71,"targetDuration":10,"studyType":74,"phases":10,"briefSummary":75,"conditions":76,"keywords":10,"overallStatus":41,"whyStopped":10,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Tata Memorial Hospital","OTHER_GOV",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Intra-operative tumour tissue biopsies",null,"Intra-operative tumour tissue biopsies will be collected for all patients",[13],"Procedure: Intra-operative Tumor Tissue Biopsy",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Intra-operative Tumor Tissue Biopsy","The changing pattern of gene expression during surgery has never been studied. This could be an effect of acute hypoxia that sets in the tumour during surgery or could be a surgical response. To study these changes happening in the tumour during surgery, we are taking serial biopsies during surgery, one at the beginning, one midway during surgery and one at the end of surgery. These samples will be snap frozen and stored at -80 deg celsius in biorepository for future analysis.",[9],[21],"Breast cancer surgery",[23],{"name":24,"affiliation":25,"role":26},"Rajendra Badwe","Director, tata Memorial Centre","PRINCIPAL_INVESTIGATOR",[28,34],{"name":29,"role":30,"phone":31,"phoneExt":32,"email":33},"Shalaka Joshi, MS, MCh","CONTACT","9869089803","4265","drjoshishalaka@gmail.com",{"name":35,"role":30,"phone":36,"phoneExt":10,"email":37},"Rohini A Hawaldar","09820432613","rwhawaldar@gmail.com",[39],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Tata Memorial Center","RECRUITING","Mumbai","Maharashtra","400012","India","IN",{"type":48,"coordinates":49},"Point",[50,51],72.88261,19.07283,{"lat":51,"lon":50},[54,56],{"name":29,"role":30,"phone":55,"phoneExt":32,"email":33},"22241608601",{"name":57,"role":30,"phone":36,"phoneExt":10,"email":37},"Rohini A Hawaldar, BSc",{"type":26,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":61,"oldNameTitle":10,"oldOrganization":10},"Dr Rajendra A. Badwe","Director, Tata Memorial Centre and Professor, Department of Surgical Oncology","Tata Memorial Centre","100346956","a-prospective-evaluation-of-the-peri-operative-hypoxia-in-breast-cancer-100346956",false,"NCT03797482","A Prospective Evaluation of the Peri-operative Hypoxia in Breast Cancer","Hypoxia","Inclusion Criteria:\n\n1. Clinically diagnosis of breast cancer (by FNAC or Biopsy)\n2. Not received any chemotherapy or surgical intervention except core biopsy.\n3. Planed for Breast cancer surgery\n4. Willing to give consent for the study\n\nExclusion Criteria:\n\n1. Clinically diagnosis of Metastatic breast cancer\n2. Received any anticancer therapy","FEMALE","18 Years",{"count":72,"type":73},500,"ESTIMATED","OBSERVATIONAL","To understand the effects induced by acute hypoxia that sets in during surgery in breast cancer. To study this, clinical samples (Tumor biopsies) will be obtained during the surgery after partial devascularisation (sample B) and stored for future genomic and proteonomic evaluations.",[77],"Breast Cancer Female","2025-09-03",{"date":80,"type":81},"2025-09-10","ACTUAL",{"date":83,"type":81},"2017-11-27",{"date":85,"type":73},"2025-11-30",{"name":5,"class":6},1]