[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616946":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":14,"centralContacts":18,"locations":27,"responsibleParty":54,"collaborators":10,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":10,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":10,"studyType":69,"phases":10,"briefSummary":70,"conditions":71,"keywords":10,"overallStatus":29,"whyStopped":10,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Massachusetts General Hospital","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Healthy pregnant women residing at high altitude",null,"Women with uncomplicated pregnancy.",{"label":13,"type":10,"description":11,"interventionNames":10},"Healthy pregnant women residing at sea level",[15],{"name":16,"affiliation":5,"role":17},"Lorenzo Berra, MD","PRINCIPAL_INVESTIGATOR",[19,23],{"name":16,"role":20,"phone":21,"phoneExt":10,"email":22},"CONTACT","617-726-3030","lberra@mgh.harvard.edu",{"name":24,"role":20,"phone":25,"phoneExt":10,"email":26},"Andrea Bolchini, MD","617-216-5124","abolchini@mgh.harvard.edu",[28,43],{"facility":5,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"RECRUITING","Boston","Massachusetts","02114","United States","US",{"type":36,"coordinates":37},"Point",[38,39],-71.05977,42.35843,{"lat":39,"lon":38},[42],{"name":16,"role":20,"phone":10,"phoneExt":10,"email":10},{"facility":44,"status":45,"city":46,"state":10,"zip":10,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":53,"contacts":10},"Hospital De La Meujer","COMPLETED","La Paz","Bolivia","BO",{"type":36,"coordinates":50},[51,52],-68.15,-16.5,{"lat":52,"lon":51},{"type":17,"investigatorFullName":16,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PI","100616946","a-prospective-longitudinal-observational-cohort-study-of-pregnant-women-residing-at-high-altitude-in-bolivia-100616946",false,"NCT07312227","A Prospective Longitudinal Observational Cohort Study of Pregnant Women Residing at High Altitude in Bolivia","Inclusion Criteria:\n\n* women delivering at participating hospitals at more than 3500 meters or women delivering at participating hospitals at sea level\n* signed informed consent\n\nExclusion Criteria:\n\n* preexisting cardiopulmonary pathologies (CHD, COPD, CKD, NYHA \\> III)",true,"FEMALE","18 Years","45 Years",{"count":67,"type":68},27,"ESTIMATED","OBSERVATIONAL","In this study, the investigators will follow two small cohorts of pregnant women: a cohort of healthy women with uncomplicated pregnancies residing at high altitude, a control group of healthy women with uncomplicated pregnancies residing at sea level, to characterize differences in cardiopulmonary adaptation and nitric oxide (NO) pathway expression at elevations \\>3,500 m throughout pregnancy and into the postpartum period. The investigators aim to investigate right-sided cardiac impairment induced by chronic hypobaric hypoxemia, its effects on fetal growth, and the potential contribution of cardiovascular nitric oxide depletion to obstetric complications.",[72,73,74],"Hypertensive Disorder of Pregnancy","Pulmonary Arterial Hypertension","Intrauterine Growth Restriction","2026-05-21",{"date":77,"type":78},"2026-05-26","ACTUAL",{"date":80,"type":78},"2026-02-11",{"date":82,"type":68},"2027-02",{"name":5,"class":6},2]