[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100495434":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":29,"responsibleParty":66,"collaborators":10,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":72,"acronym":10,"eligibilityCriteria":73,"healthyVolunteers":74,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":10,"studyType":81,"phases":10,"briefSummary":82,"conditions":83,"keywords":86,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"National Institutes of Health Clinical Center (CC)","NIH",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"First Degree Relatives",null,"Siblings or parents of patients.",{"label":13,"type":10,"description":14,"interventionNames":10},"Patients","Patients with lymphatic anomalies.",[16],{"name":17,"affiliation":18,"role":19},"Sarah E Sheppard, M.D.","Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","PRINCIPAL_INVESTIGATOR",[21,26],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Andrea I Bowling, C.R.N.P.","CONTACT","(301) 451-3824","nichd_lymphaticanoma@mail.nih.gov",{"name":17,"role":23,"phone":27,"phoneExt":10,"email":28},"(240) 578-5047","sarah.sheppard@nih.gov",[30,50],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"National Institutes of Health Clinical Center","RECRUITING","Bethesda","Maryland","20892","United States","US",{"type":39,"coordinates":40},"Point",[41,42],-77.10026,38.98067,{"lat":42,"lon":41},[45],{"name":46,"role":23,"phone":47,"phoneExt":48,"email":49},"NIH Clinical Center Office of Patient Recruitment (OPR)","800-411-1222","TTY dial 711","ccopr@nih.gov",{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":36,"countryCode":37,"cosmosGeoPoint":56,"geoPoint":60,"contacts":61},"Children's Hospital of Philadelphia","NOT_YET_RECRUITING","Philadelphia","Pennsylvania","19104",{"type":39,"coordinates":57},[58,59],-75.16362,39.95238,{"lat":59,"lon":58},[62],{"name":63,"role":23,"phone":64,"phoneExt":10,"email":65},"Yoav Dori","267-648-1033","doriy@chop.edu",{"type":67,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100495434","a-prospective-natural-history-study-of-lymphatic-anomalies-100495434",false,"NCT05731141","A Prospective Natural History Study of Lymphatic Anomalies","* INCLUSION CRITERIA:\n\nAffected (Proband)\n\nIn order to be eligible to participate in this study, an individual must meet one of the following criteria as determined after review of medical history:\n\n* Current or history of lymphatic anomaly or symptoms suggestive of a lymphatic disorder Or\n* An ill-defined vascular anomaly that is suspected to have an abnormal lymphatic component Or\n* A pathogenic, likely pathogenic, or VUS in a genetic disorder with a known lymphatic component Or\n* Clinical diagnosis of a syndrome with a known lymphatic component\n\nUnaffected (First Degree Relatives: Parents and Siblings)\n\nGenetic variants underlying complex lymphatic anomalies can be passed down through parents or be new in a child (de novo). Inclusion of first-degree relatives will assist in genetic analysis to delineate whether the variant is inherited or de novo.\n\nTo be eligible to participate as a first degree relative in this study, an individual must be a first-degree family member of an affected participants\n\nEXCLUSION CRITERIA:\n\nAffected Proband\n\nAn individual who meets any of the following criteria will be excluded from participation in this study after review of medical history, concomitant medication and allergy review, anthropometrics, and performance status:\n\n-Any condition, in the opinion of the investigator, that would increase risk of participation or impair their ability to comply with protocol requirements.\n\nLymphatic anomalies that are definitively determined to be secondary by the principal investigator will be excluded from this study. For example, participants who develop a lymphedema after breast cancer surgery.\n\nUnaffected (First Degree Relatives)\n\n-Any condition, in the opinion of the investigator, that would increase risk of participation or impair their ability to comply with protocol requirements.",true,"ALL","1 Day","100 Years",{"count":79,"type":80},1200,"ESTIMATED","OBSERVATIONAL","Background:\n\nThe lymphatic system is a network of vessels that carry a clear fluid called lymph through the body. Problems in the lymphatic system can cause pain, fluid buildup, and issues with immunity. There is much researchers do not understand about lymphatic anomalies. In this natural history study, they will collect data from a lot of people over a long time.\n\nObjective:\n\nTo better understand why lymphatic anomalies develop. The goal is to improve future treatments.\n\nEligibility:\n\nPeople aged 0 days and older with a suspected or confirmed lymphatic anomaly. Their unaffected parents or siblings aged 7 years or older are also needed.\n\nDesign:\n\nParticipants may remain in the study indefinitely. Affected participants may be evaluated every 10 months to 2 years. Some participants will be seen over telemedicine. Others will be seen at the NIH Clinical Center for 2-5 days.\n\nAll participants will have a physical exam. They may provide specimens including blood, saliva, hair follicles, stool, skin, and other tissues. Samples may be used for genetic testing.\n\nParticipants may undergo other tests depending on their medical conditions. The NIH Clinical Center visit may include:\n\nHeart tests include placing stickers on the chest to measure electrical activity and using sound waves to capture pictures of the heart.\n\nA lung test measures the muscle strength in the chest. Participants will blow into a tube.\n\nPhotographs may be taken of participants faces and other features.\n\nImaging scans will take pictures of the inside of the body. One scan will measure bone density.\n\nOne type of scan tracks how lymph fluid moves through the body. Participants will be under anesthesia, and they will be injected with a dye.",[84,85],"Lymphatic Diseases","Lymphatic Abnormalities",[87,88,89,90,91,92,93,94,95,96],"Protein Losing Enteropathy","Lymphedema","Lymphangiectasia","Kaposiform Lymphangiomatosis","Gorham Stout Disease","Generalized Lymphatic Anomaly","Complex Lymphatic Anomaly","Chylous Effusion","Chylous Ascites","Central Conducting Lymphatic Anomaly","2026-06-24",{"date":99,"type":100},"2026-06-25","ACTUAL",{"date":102,"type":100},"2023-03-20",{"date":104,"type":80},"2028-12-31",{"name":18,"class":6},2]