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If receiving nonbiologic therapies for inflammatory bowel disease, including thiopurines and methotrexate, must have initiated at least 3 months prior to screening and must be on a stable dose for at least 2 weeks prior to screening.\n8. If receiving oral corticosteroids, the participant is eligible if they meet all the following criteria:\n\n   * The dose is up to a maximum of prednisone ≤ 40 mg\u002Fday or budesonide ≤ 9 mg\u002Fday or equivalent.\n   * The dose has been stable for ≥ 2 weeks prior to screening.\n   * The participant is willing to initiate a corticosteroid taper within 2 weeks after initiating biologic treatment.\n9. In the opinion of the investigator, the participant is able to understand and comply with protocol requirements including treatment as assigned per the protocol.\n10. Able to participate fully in all aspects of this clinical study. Full comprehension of consent language and informed consent must be obtained from the participant, or the participant's legally acceptable representative, and documented\n\nExclusion Criteria:\n\nParticipants who meet any of the following criteria are to be excluded from the study:\n\n1. Prior treatment with VDZ or UST.\n2. Prior treatment with more than 1 advanced therapy (eg, any biologic \\[ie, anti- tumour necrosis factor (TNF), anti-interleukin, anti-integrin\\]) or advanced oral small molecule \\[ie, Janus kinase inhibitor\\]) for CD.\n3. CD-related complications that in the opinion of the investigator would interfere with participation in the study, including but not limited to:\n\n   * Ileorectal anastomosis (rectum \\\u003C 15 cm), or a proctocolectomy.\n   * Short bowel syndrome.\n   * All ostomies.\n   * Symptomatic strictures in the bowel or symptomatic strictures in the ileum or ileocecal valve that have a stenosis.\n   * Suspected or diagnosed active intra-abdominal or perianal abscess that have not been appropriately treated.\n4. History or current diagnosis of ulcerative colitis (unless this diagnosis was made erroneously), indeterminate colitis, idiopathic colitis (ie, colitis not consistent with CD), microscopic colitis, or colonic mucosal dysplasia (excluding dysplasia in resected adenomas).\n5. Increased risk of infectious complications (eg, recent pyogenic infection, any congenital or acquired immunodeficiency, or past organ, bone marrow, or stem cell transplantation).\n6. Any topical rectal therapy for treatment of CD within 2 weeks prior to the screening endoscopy.\n7. Nonsteroidal anti-inflammatory drugs (NSAIDs) as chronic treatment, except for cyclooxygenase-2logic selective NSAIDS (celecoxib).\n8. Faecal microbiota transplant (includes human microbiota-based therapeutics) within 4 weeks prior to randomisation.\n9. Any major surgery (in the investigator's opinion) performed within 8 weeks prior to randomisation or planned during the study.\n10. History of excessive alcohol or drug abuse that, in the opinion of the investigator, may interfere with the participant's ability to comply with the study procedures.\n11. Serious underlying disease other than CD that in the opinion of the investigator may interfere with the participant's ability to participate fully in the study or would compromise participant safety (such as history of malignancies, major neurological disorders, any unstable or uncontrolled medical disorder, or any known or suspected contraindication to any of the study biologics according to local prescribing information).","ALL","18 Years",{"count":544,"type":545},378,"ESTIMATED","INTERVENTIONAL",[548],"NA","This is a multicentre, prospective, randomised, controlled, open-label study to assess the efficacy, safety, and cost-effectiveness of epigenome-guided treatment selection compared to usual standard-of-care (SOC) treatment selection in patients initiating biologic therapy for the treatment of their active Crohn's Disease (CD).",[551],"Crohn Disease (CD)","2026-05-28",{"date":554,"type":555},"2026-06-01","ACTUAL",{"date":557,"type":555},"2025-02-01",{"date":559,"type":545},"2029-01",{"name":5,"class":6},39]