[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100589405":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":36,"centralContacts":41,"locations":52,"responsibleParty":74,"collaborators":70,"id":78,"slug":79,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":70,"eligibilityCriteria":84,"healthyVolunteers":80,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":70,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":70,"overallStatus":55,"whyStopped":70,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Asian Institute of Gastroenterology, India","OTHER",[8,13,17],{"label":9,"type":6,"description":10,"interventionNames":11},"To determine whether Vonaprazon 10mg heals grade B esophagitis at 8 weeks","Vonaprazon 10 mg heals gerd symptoms after 8 weeks",[12],"Drug: Vonoprazan",{"label":14,"type":6,"description":15,"interventionNames":16},"To determine whether Vonaprazon 20mg heals grade B esophagitis at 8 weeks","Vonaprazon 20 mg heals gerd symptoms after 8 weeks",[12],{"label":18,"type":6,"description":19,"interventionNames":20},"To determine whether esomeprazole 40mg heals grade B esophagitis at 8 weeks","Esomeprazole 40mg heals gerd symptoms after 8 weeks",[21],"Drug: Esomeprazole 40mg",[23,30],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"DRUG","Vonoprazan","Vonaprazon is potassium competitive acid blockers",[9,14],[29],"PCAB",{"type":24,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"Esomeprazole 40mg","esomeprazole is a proton pump inhibitor as it prevents excess of gastric acid secretion in the stomach",[18],[35],"Proton pump inhibitor",[37],{"name":38,"affiliation":39,"role":40},"Mohan Dr Ramchandani, MD DM","Asian Institute of Gastroenterology","STUDY_DIRECTOR",[42,48],{"name":43,"role":44,"phone":45,"phoneExt":46,"email":47},"Rajesh Goud Mr Maragoni, M.Pharm","CONTACT","04023378888","410","rajeshgoud761@gmail.com",{"name":49,"role":44,"phone":45,"phoneExt":50,"email":51},"Zaheer Dr Nabi, MD DNB","503","zaheernabi1978@gmail.com",[53],{"facility":54,"status":55,"city":56,"state":57,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"Asian Institute of Gastroenterology \u002FAig Hospitals","RECRUITING","Hyderabad","Telangana","500082","India","IN",{"type":62,"coordinates":63},"Point",[64,65],78.45636,17.38405,{"lat":65,"lon":64},[68,71],{"name":69,"role":44,"phone":45,"phoneExt":70,"email":51},"ZAHEER DR NABI, MBBS MDDNB",null,{"name":72,"role":44,"phone":45,"phoneExt":73,"email":47},"Rajesh Goud Mr Maragoni, M.Pharm MBA","301",{"type":75,"investigatorFullName":76,"investigatorTitle":77,"investigatorAffiliation":5,"oldNameTitle":70,"oldOrganization":70},"PRINCIPAL_INVESTIGATOR","Mohan Ramchandani","Director","100589405","a-randomized-three-arm-study-comparing-vonaprazan-10-mg-vonaprazan-20-mg-and-esomeprazole-40-mg-for-the-healing-of-la-grade-b-or-higher-reflux-esophagitis-at-8-weeks-100589405",false,"NCT06953986","A Randomized, Three-Arm Study Comparing Vonaprazan 10 mg, Vonaprazan 20 mg, and Esomeprazole 40 mg for the Healing of LA Grade B or Higher Reflux Esophagitis at 8 Weeks","Study Comparing Vonaprazan 10 mg, Vonaprazan 20 mg, and Esomeprazole 40 mg for the Healing of LA Grade B or Higher Reflux Esophagitis at 8 Weeks","Inclusion Criteria:\n\n* Adults ≥18 years of age.\n* Endoscopically confirmed LA grade B, C, or D reflux esophagitis.\n* GERD symptoms (heartburn, regurgitation) for at least 4 weeks prior to enrollment.\n* Willing to provide informed consent and comply with study procedures.\n\nExclusion Criteria:\n\n* Previous or ongoing treatment with Vonaprazan or Esomeprazole in the last 4 weeks.\n* Prior esophageal surgery or radiation therapy.\n* Barrett's esophagus, esophageal stricture, or malignancy.\n* Pregnant or breastfeeding women.\n* History of PPI-refractory GERD or severe gastroparesis.\n* Significant hepatic or renal impairment (ALT\u002FAST \\>3× ULN, eGFR \\\u003C30 mL\u002Fmin).\n* Use of NSAIDs, steroids, or anticoagulants affecting healing.","ALL","18 Years","75 Years",{"count":89,"type":90},414,"ESTIMATED","INTERVENTIONAL",[93],"NA","Primary Objective\n\n• To compare the healing rates of LA grade B or higher reflux esophagitis at 8 weeks among patients treated with Vonaprazan 10 mg, Vonaprazan 20 mg, and Esomeprazole 40 mg once daily.\n\nSecondary Objectives\n\n* To assess the improvement in reflux symptoms using the GERD-Q score at 8 weeks.\n* To evaluate the incidence of adverse events across treatment groups.",[96],"GERD","2026-03-04",{"date":99,"type":100},"2026-03-06","ACTUAL",{"date":102,"type":100},"2025-12-20",{"date":104,"type":90},"2027-12-12",{"name":5,"class":6},1]