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The guardian understands and signs the informed consent form (both parents must sign), and adheres to the relevant requirements of this study. If the participant is 8 years old or older, they must also sign the informed consent form. For participants under 8 years old who can express consent, their consent must be clearly documented.\n  2. Age: ≥1 year and \\\u003C13 years, either sex;\n  3. Positive for HBsAg and\u002For HBV DNA for more than 6 months;\n  4. No prior antiviral treatment.\n* Treated Group:\n\n  1. The guardian understands and signs the informed consent form (both parents must sign), and adheres to the relevant requirements of this study. If the participant is 8 years old or older, they must also sign the informed consent form. For participants under 8 years old who can express consent, their consent must be clearly documented.\n  2. Age: ≥3 years and \\\u003C13 years, either sex;\n  3. Previously diagnosed with chronic hepatitis B and received antiviral treatment with NAs for more than 1 year and currently on treatment;\n  4. No history of IFNα use in the past 6 months;\n  5. Negative for HBV DNA;\n  6. HBsAg quantification \\\u003C10,000 IU\u002Fml (HBsAg can be negative in the drug discontinuation observation group);\n  7. The drug discontinuation observation group must also achieve negative HBV DNA and HBeAg seroconversion for at least 1 year (based on continuous results from three consecutive reviews), and HBsAg \\\u003C10,000 IU\u002Fml; NAs will be discontinued after enrollment.\n\nExclusion Criteria:\n\n* 1.In the interferon group, blood white blood cell count \\\u003C3.5×10\\^9\u002FL, or platelet count \\\u003C80×10\\^9\u002FL, or prothrombin activity \\\u003C60%, or total bilirubin \\>34μmol\u002FL, or serum albumin \\\u003C35g\u002FL, or serum creatinine \\>133μmol\u002FL; 2.Coexistence of other active infections; 3. 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