[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630165":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":11,"collaborators":10,"id":15,"slug":16,"hasResults":17,"nctId":18,"briefTitle":19,"officialTitle":19,"acronym":10,"eligibilityCriteria":20,"healthyVolunteers":17,"sex":21,"minAge":22,"maxAge":10,"enrollmentInfo":23,"targetDuration":10,"studyType":26,"phases":10,"briefSummary":27,"conditions":28,"keywords":10,"overallStatus":30,"whyStopped":10,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":10},{"fullName":5,"class":6},"Southeast University, China","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":10},"Patients in the ICU received mechanical ventilation",null,{"type":12,"investigatorFullName":13,"investigatorTitle":14,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Ling Liu","Professor","100630165","a-retrospective-clinical-study-of-metabolic-status-and-response-to-nutritional-therapy-in-patients-with-mechanical-ventilation-100630165",false,"NCT07484126","A Retrospective Clinical Study of Metabolic Status and Response to Nutritional Therapy in Patients With Mechanical Ventilation","Inclusion Criteria:\n\n* age ≥18 years old;\n* ICU admission ≥72 hours with invasive mechanical ventilation ≥24 hours;\n* start nutrition therapy within 72 hours after ICU admission and receive enteral or parenteral nutrition support for ≥3 days;\n* Relatively complete nutritional intervention records and nutrition-related biomarkers test results on the 1st, 3rd, and 7th (±1) days of ICU admission;\n\nExclusion Criteria:\n\n* women of childbearing age who have a positive pregnancy test, are pregnant or lactating;\n* chronic diseases with serious organ function damage or serious complications;\n\n  1. Kidney: chronic kidney disease stage 4 or 5;\n  2. Liver: previous history of liver failure, hepatic encephalopathy, or hepatic coma, gastrointestinal bleeding due to portal hypertension or Child-Pugh score ≥10 in recent years;\n* advanced malignant tumor, or chemotherapy or immunotherapy received within one month before admission;\n* severe immunodeficiency or current use of potent immunosuppressive agents, agranulocytosis (N\\\u003C0.5×10\\^9\u002FL), active hematologic malignancies or HIV stage III infection; Patients who were treated with immune-inducing drugs, such as antithymocyte globulin (ATG), antilymphocyte globulin (ALG), interleukin-2 receptor a chain antibody (IL-2RA), interleukin-6 receptor A antibody (IL-6RA); glucocorticoid therapy was continued for nearly 2 weeks, with a daily dose exceeding the hydrocortisone equivalent of 200mg;\n* critical illness, death in ICU within 1 week or palliative care only because death outcome was inevitable;\n* combined with severe or more severe burns: more than 30% of total body surface area burned or more than 10% of third-degree burn area; Or the total area is less than 30%, but the whole body condition is severe, or there are shock, combined injury, and respiratory tract burn.","ALL","18 Years",{"count":24,"type":25},2000,"ESTIMATED","OBSERVATIONAL","This study used a retrospective cohort study based on Multi-time longitudinal monitoring data were used to analyze the correlation mechanism between the dynamic evolution characteristics of nutrition-related biochemical indicators and individualized nutritional intervention in patients with mechanical ventilation. The inflammation-nutrition interaction model was constructed to correct the interference effect of inflammatory microenvironment on nutritional status assessment, so as to provide a basis for further achieving precision nutritional support.",[29],"Mechanical Ventilation","NOT_YET_RECRUITING","2026-03-17",{"date":33,"type":34},"2026-03-19","ACTUAL",{"date":36,"type":25},"2026-04",{"date":38,"type":25},"2026-08",{"name":5,"class":6}]