[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100506654":3},{"organization":4,"armGroups":7,"interventions":31,"overallOfficials":62,"centralContacts":66,"locations":73,"responsibleParty":107,"collaborators":109,"id":112,"slug":113,"hasResults":114,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":118,"eligibilityCriteria":119,"healthyVolunteers":120,"sex":121,"minAge":122,"maxAge":71,"enrollmentInfo":123,"targetDuration":71,"studyType":126,"phases":127,"briefSummary":129,"conditions":130,"keywords":71,"overallStatus":75,"whyStopped":71,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":146},{"fullName":5,"class":6},"Arizona State University","OTHER",[8,14,20,26],{"label":9,"type":10,"description":11,"interventionNames":12},"Moderate Intensity Continuous Training (MICT)","EXPERIMENTAL","Cycling on recumbent stationary cycle at moderate intensity for 30-50 minutes, 3 times per week for 3-6 months",[13],"Behavioral: Moderate Intensity Continuous Training (MICT)",{"label":15,"type":16,"description":17,"interventionNames":18},"Chair-based Stretch","SHAM_COMPARATOR","Stretching at low intensity for 30-50 minutes, 3 times per week for 6 months",[19],"Behavioral: Chair-based Stretch",{"label":21,"type":22,"description":23,"interventionNames":24},"High-Intensity Interval Training (HIIT)","ACTIVE_COMPARATOR","MICT for 3 months, and then cycling on recumbent stationary cycle at alternate high and moderate intensity for 40 minutes, 3 times per week for 3 months.",[25],"Behavioral: High-Intensity Interval Training (HIIT)",{"label":27,"type":22,"description":28,"interventionNames":29},"Combined Aerobic Resistance Exercise (CARE)","MICT for 3 months, and then cycling on recumbent stationary cycle at moderate intensity for 30 minutes, followed by 20-minute strength-building exercise, 3 times per week for 3 months.",[30],"Behavioral: Combined Aerobic Resistance Exercise (CARE)",[32,40,47,54],{"type":33,"name":9,"description":34,"armGroupLabels":35,"otherNames":36},"BEHAVIORAL","Aerobic cycling at a moderate intensity (50-75% of heart rate reserve) for 30-50 minutes, 3 times per week for 3-6 months.",[9],[37,38,39],"Continuous Training","Aerobic exercise","Cardio",{"type":33,"name":15,"description":41,"armGroupLabels":42,"otherNames":43},"Stretching while seated for 30-50 minutes, 3 times per week for 6 months.",[15],[44,45,46],"Stretch","Range of motion","flexibility",{"type":33,"name":21,"description":48,"armGroupLabels":49,"otherNames":50},"Aerobic cycling at a vigorous intensity (80-90% of heart rate reserve 4-minute bouts with 4-minute recovery intervals) for 40 minutes, 3 times per week for 3 months.",[21],[51,52,53],"HIIT","Vigorous training","Hard exercise",{"type":33,"name":27,"description":55,"armGroupLabels":56,"otherNames":57},"6 full-body strength-building exercises followed by 30 minutes of MICT cycling (described above). Total duration is 60 minutes, 3 times per week for 3 months.",[27],[58,59,60,61],"Strength and Cardio Training","CARE","Combination training","Exercise training",[63],{"name":64,"affiliation":5,"role":65},"Fang Yu, PhD","PRINCIPAL_INVESTIGATOR",[67],{"name":68,"role":69,"phone":70,"phoneExt":71,"email":72},"Kristi Spieleder, MS","CONTACT","480-884-2765",null,"kspieled@asu.edu",[74],{"facility":5,"status":75,"city":76,"state":77,"zip":78,"country":79,"countryCode":80,"cosmosGeoPoint":81,"geoPoint":86,"contacts":87},"RECRUITING","Phoenix","Arizona","85004","United States","US",{"type":82,"coordinates":83},"Point",[84,85],-112.07404,33.44838,{"lat":85,"lon":84},[88,89,90,93,95,97,99,101,103,105],{"name":68,"role":69,"phone":70,"phoneExt":71,"email":72},{"name":64,"role":65,"phone":71,"phoneExt":71,"email":71},{"name":91,"role":92,"phone":71,"phoneExt":71,"email":71},"David Coon, PhD","SUB_INVESTIGATOR",{"name":94,"role":92,"phone":71,"phoneExt":71,"email":71},"Rodney Joseph, PhD",{"name":96,"role":92,"phone":71,"phoneExt":71,"email":71},"Michael Todd, PhD",{"name":98,"role":92,"phone":71,"phoneExt":71,"email":71},"Molly Maxfield, PhD",{"name":100,"role":92,"phone":71,"phoneExt":71,"email":71},"Jeremy Pruzin, MD",{"name":102,"role":92,"phone":71,"phoneExt":71,"email":71},"Yi Su, MD",{"name":104,"role":92,"phone":71,"phoneExt":71,"email":71},"Dereck Salisbury, PhD",{"name":106,"role":92,"phone":71,"phoneExt":71,"email":71},"Danni Li, PhD",{"type":108,"investigatorFullName":71,"investigatorTitle":71,"investigatorAffiliation":71,"oldNameTitle":71,"oldOrganization":71},"SPONSOR",[110],{"name":111,"class":6},"Banner Alzheimer's Institute","100506654","a-smart-trial-of-adaptive-exercises-to-optimize-aerobic-fitness-responses-100506654",false,"NCT05877196","A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses","Precision Medicine in Alzheimer's Disease: A SMART Trial of Adaptive Exercises and Their Mechanisms of Action Using AT(N) Biomarkers to Optimize Aerobic-Fitness Responses (The FIT-AD SMART Trial)","SMART","Inclusion Criteria:\n\nParticipants:\n\n* Clinical diagnosis of MCI or probable and possible mild AD dementia according to 2011 Alzheimer's association-NIA criteria.\n* Community-dwelling, e.g., homes and assisted living\n* Age 65 years and older\n* Medical clearance from PCP or cardiovascular provider\n* Have a qualified study partner\n* Agree to the blood draws\n* Verified MRI safety\n\nStudy Partner:\n\n* Age 18 or older\n* Contact with participant ≥ 2 times per week for ≥ 6 months\n* Know the participant's memory status and ability to perform activities of daily living\n* Consent to participant\n\nExclusion Criteria:\n\nParticipants\n\n* Resting HR ≤ 50 or ≥ 100 beats\u002Fmin after 5-minutes of quiet resting\n* American College of Sports Medicine contraindications to exercise\n* New, unevaluated symptoms or diseases a healthcare provider has not evaluated\n* Abnormal cardiac condition uncovered during VO2peak testing\n* Enrollment in another intervention that aims at improving cognition\n* Moderate to strenuous exercise ≥150 minutes a week in the previous 6 months\n* ≥ 2 anti-depression medications, or poorly managed or unstable depression\n* Poorly managed or unstable anxiety\n\nStudy partners:\n\n* none",true,"ALL","65 Years",{"count":124,"type":125},216,"ESTIMATED","INTERVENTIONAL",[128],"NA","The goal of this clinical trial is to test 6 months of aerobic exercise in older adults who are 65 years or older and have mild cognitive impairment (MCI) or probable\u002Fpossible mild Alzheimer's Disease. The main questions it aims to answer are:\n\n* test the effects of aerobic exercise on aerobic fitness, white matter hyperintensity (WMH) volume, and patient-centered outcomes;\n* identify the best exercise to improve aerobic fitness and reduce non-responses over 6 months; and\n* examines the mechanisms of aerobic exercise's action on memory in older adults with early AD.\n\nParticipants will receive 6 months of supervised exercise, undergo cognitive data collection and exercise testing 5 times over a year span, have an MRI brain scan 3 times over a one-year span, and have monthly follow-up discussions on health and wellness.",[131,132,133,134,135,136],"Mild Cognitive Impairment","Alzheimer Disease","Cognitive Impairment","Cognitive Decline","Memory Loss","Memory Impairment","2026-05-01",{"date":139,"type":140},"2026-05-05","ACTUAL",{"date":142,"type":140},"2023-06-22",{"date":144,"type":125},"2028-06-30",{"name":5,"class":6},1]