[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100609731":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":28,"locations":34,"responsibleParty":137,"collaborators":10,"id":139,"slug":140,"hasResults":141,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":145,"eligibilityCriteria":146,"healthyVolunteers":141,"sex":147,"minAge":148,"maxAge":10,"enrollmentInfo":149,"targetDuration":10,"studyType":152,"phases":10,"briefSummary":153,"conditions":154,"keywords":10,"overallStatus":156,"whyStopped":10,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":166},{"fullName":5,"class":6},"Takeda","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Retrospective Phase",null,"All participants who were diagnosed with HAE-C1INH type1 or type2 from January 2015 to August 2025; retrospective clinical data will be extracted for 5 months exclusively from patients' medical charts, and no direct patient interaction will occur.",[13],"Other: No intervention",{"label":15,"type":10,"description":16,"interventionNames":17},"Prospective Phase","All participants with any newly diagnosed or admitted or follow-up HAE-C1INH type1 or type2; prospective clinical data will be actively collected over 12 months through routine visits and electronic data capture (EDC) entries.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"OTHER","No intervention","This is a non-interventional study.",[15,9],[25],{"name":26,"affiliation":5,"role":27},"Study Director","STUDY_DIRECTOR",[29],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},"Takeda Contact","CONTACT","+1-877-825-3327","medinfoUS@takeda.com",[35,55,70,85,96,111,122],{"facility":36,"status":10,"city":37,"state":10,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Mansoura university hospital","Al Mansurah","35511","Egypt","EG",{"type":42,"coordinates":43},"Point",[44,45],31.38069,31.03637,{"lat":45,"lon":44},[48,52],{"name":49,"role":31,"phone":50,"phoneExt":10,"email":51},"Site Contact","(002)01066266746","besarmarwa@gmail.com",{"name":53,"role":54,"phone":10,"phoneExt":10,"email":10},"Marwa abo elmaaty","PRINCIPAL_INVESTIGATOR",{"facility":56,"status":10,"city":57,"state":10,"zip":58,"country":39,"countryCode":40,"cosmosGeoPoint":59,"geoPoint":63,"contacts":64},"Alexandria university_Clinical Research Center","Alexandria","21526",{"type":42,"coordinates":60},[61,62],29.91582,31.20176,{"lat":62,"lon":61},[65,68],{"name":49,"role":31,"phone":66,"phoneExt":10,"email":67},"(002)01274476086","walaashoman@hotmail.com",{"name":69,"role":54,"phone":10,"phoneExt":10,"email":10},"Walaa Shoman",{"facility":71,"status":10,"city":72,"state":10,"zip":73,"country":39,"countryCode":40,"cosmosGeoPoint":74,"geoPoint":78,"contacts":79},"Ain shams university hospital_Pediatrics","Cairo","11535",{"type":42,"coordinates":75},[76,77],31.24967,30.06263,{"lat":77,"lon":76},[80,83],{"name":49,"role":31,"phone":81,"phoneExt":10,"email":82},"(002)01007448085","elham.hossny@gmail.com",{"name":84,"role":54,"phone":10,"phoneExt":10,"email":10},"Elham Hossny",{"facility":86,"status":10,"city":72,"state":10,"zip":73,"country":39,"countryCode":40,"cosmosGeoPoint":87,"geoPoint":89,"contacts":90},"Ain shams university hospital",{"type":42,"coordinates":88},[76,77],{"lat":77,"lon":76},[91,94],{"name":49,"role":31,"phone":92,"phoneExt":10,"email":93},"(002)01001525144","Dinasheha@med.asu.edu.eg",{"name":95,"role":54,"phone":10,"phoneExt":10,"email":10},"Dina Sheha",{"facility":97,"status":10,"city":98,"state":10,"zip":99,"country":39,"countryCode":40,"cosmosGeoPoint":100,"geoPoint":104,"contacts":105},"Cairo university hospital_Pediatrics","Giza","11632",{"type":42,"coordinates":101},[102,103],31.20861,30.00944,{"lat":103,"lon":102},[106,109],{"name":49,"role":31,"phone":107,"phoneExt":10,"email":108},"(002)01223985147","aisha_mars@hotmail.com",{"name":110,"role":54,"phone":10,"phoneExt":10,"email":10},"Aisha Elmarsafy",{"facility":112,"status":10,"city":98,"state":10,"zip":99,"country":39,"countryCode":40,"cosmosGeoPoint":113,"geoPoint":115,"contacts":116},"Cairo university hospital",{"type":42,"coordinates":114},[102,103],{"lat":103,"lon":102},[117,120],{"name":49,"role":31,"phone":118,"phoneExt":10,"email":119},"(002)01001833370","nohakhalil78@hotmail.com",{"name":121,"role":54,"phone":10,"phoneExt":10,"email":10},"Noha Khalil",{"facility":123,"status":10,"city":124,"state":10,"zip":125,"country":39,"countryCode":40,"cosmosGeoPoint":126,"geoPoint":130,"contacts":131},"Zagazig university hospital","Zagazig","44511",{"type":42,"coordinates":127},[128,129],31.502,30.58768,{"lat":129,"lon":128},[132,135],{"name":49,"role":31,"phone":133,"phoneExt":10,"email":134},"(002)01090419880","alqurashilobna@yahoo.com",{"name":136,"role":54,"phone":10,"phoneExt":10,"email":10},"Lobna Elkorashy",{"type":138,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100609731","a-study-about-the-diagnosis-and-management-of-hereditary-angioedema-hae-in-egypt-100609731",false,"NCT07218393","A Study About the Diagnosis and Management of Hereditary Angioedema (HAE) in Egypt","Retrospective and Prospective Real-World Evidence (RWE) Study Investigating Diagnosis and Therapeutic Management of Patients With HAE Type I or II in the Current Medical Practice in Egypt: the EXPLORHAE Study (EXPLORing Prospective and Retrospective Health Assessments of HAE in Egypt)","EXPLORHAE","Inclusion Criteria: Retrospective Phase:\n\n1. The participant has a confirmed HAE-C1INH type1 or type2 diagnosis in medical records (based on clinical history and\u002For laboratory diagnosis in medical records).\n2. The participant was diagnosed and\u002For treated from January 2015 to August 2025.\n\nInclusion Criteria: Prospective Phase:\n\n1. The participant has a physician-confirmed HAE-C1INH type1 or type2 diagnosis (based on clinical history and\u002For laboratory diagnosis).\n2. The participant signed an informed consent or assent.\n3. The participant should have had at least one visit to the treating physician\u002Finvestigator during enrollment and the follow-up period.\n4. The participant was not enrolled in the study's retrospective phase.\n\nExclusion Criteria: (For both retrospective and prospective phases):\n\n1. Participant with AAE-C1INH (acquired angioedema), drug-induced angioedema (AE-DI) (example angiotensin-converting enzyme inhibitors-I \\[ACE-I\\] angioedema), allergic mediated angioedema, inflammatory angioedema, or idiopathic angioedema.\n2. HAE participants with normal C1-INH (HAE-nC1INH).\n3. Participant deemed unsuitable for participation for any reason, based on the investigator's clinical judgment.","ALL","1 Year",{"count":150,"type":151},100,"ESTIMATED","OBSERVATIONAL","Hereditary angioedema (HAE) is a rare condition. It causes sudden swelling under the skin and inside the body, like in the belly, throat, or genitals. This swelling happens because of a temporary leak in blood vessels. HAE is classified based on the amount of a protein in the blood called C1 inhibitor (C1-INH): HAE with normal C1-INH levels and HAE with limited or insufficient C1-INH levels (C1-INH deficiency); HAE with C1-INH deficiency can be divided into Type1, with low levels of C1-INH, and Type 2, in which the protein is there, but does not work properly. This study will look at people with HAE Type1 or Type2.\n\nThe main aim of this study is to describe the diagnosis and management of people with HAE Type1 or HAE Type2 in Egypt. Other aims are to learn more about people with HAE Type1 or Type2, including, but not limited to, other conditions they may have, family history, impact of HAE on daily life, if treatment is stopped and the reasons.\n\nDuring the study, information from already existing data in a participant's medical record will be reviewed and new data will be collected during routine visits of a participant to the study clinic.",[155],"Hereditary Angioedema (HAE)","NOT_YET_RECRUITING","2026-06-17",{"date":159,"type":160},"2026-06-18","ACTUAL",{"date":162,"type":151},"2026-12-01",{"date":164,"type":151},"2027-12-01",{"name":5,"class":6},7]