[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100472291":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":43,"centralContacts":47,"locations":56,"responsibleParty":140,"collaborators":21,"id":142,"slug":143,"hasResults":144,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":21,"eligibilityCriteria":148,"healthyVolunteers":144,"sex":149,"minAge":150,"maxAge":21,"enrollmentInfo":151,"targetDuration":21,"studyType":154,"phases":155,"briefSummary":157,"conditions":158,"keywords":173,"overallStatus":59,"whyStopped":21,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":188},{"fullName":5,"class":6},"Memorial Sloan Kettering Cancer Center","OTHER",[8,17],{"label":9,"type":10,"description":11,"interventionNames":12},"PSRB","EXPERIMENTAL","Participants will receive mind-body resilience training\u002FMBRT, music therapy, propranolol and etodolac pre and post operatively. Postoperative Psychological Interventions may occur between POD 1-7 if needed.",[13,14,15,16],"Behavioral: Mind-body resilience training","Behavioral: Music therapy","Drug: Propranolol","Drug: Etodolac",{"label":18,"type":19,"description":20,"interventionNames":21},"Standard of Care","NO_INTERVENTION","Participants will receive usual care (study interventions not specifically recommended)",null,[23,30,34,39],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"BEHAVIORAL","Mind-body resilience training","MBRT is a meditation technique used to achieve relaxation)",[9],[29],"MBRT",{"type":24,"name":31,"description":32,"armGroupLabels":33,"otherNames":21},"Music therapy","Music listening was found, in multiple trials, to significantly reduce self-reported anxiety, physiologic indicators of anxiety, and\u002For sedation requirements",[9],{"type":35,"name":36,"description":37,"armGroupLabels":38,"otherNames":21},"DRUG","Propranolol","Propranolol 20 mg PO BID (for 21 consecutive days), Propranolol 10mg PO BID (for 3 consecutive days POD 14-16)",[9],{"type":35,"name":40,"description":41,"armGroupLabels":42,"otherNames":21},"Etodolac","Etodolac 400 mg PO BID (for 21 consecutive days)",[9],[44],{"name":45,"affiliation":5,"role":46},"Kara Long Roche, MD","PRINCIPAL_INVESTIGATOR",[48,52],{"name":45,"role":49,"phone":50,"phoneExt":21,"email":51},"CONTACT","212-639-7043","longrock@mskcc.org",{"name":53,"role":49,"phone":54,"phoneExt":21,"email":55},"Anoushka Afonso, MD","212-639-8113","afonsoa@mskcc.org",[57,74,85,96,108,119,129],{"facility":58,"status":59,"city":60,"state":61,"zip":62,"country":63,"countryCode":64,"cosmosGeoPoint":65,"geoPoint":70,"contacts":71},"Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)","RECRUITING","Basking Ridge","New Jersey","07920","United States","US",{"type":66,"coordinates":67},"Point",[68,69],-74.54932,40.70621,{"lat":69,"lon":68},[72],{"name":45,"role":49,"phone":73,"phoneExt":21,"email":21},"646-608-3787",{"facility":75,"status":59,"city":76,"state":61,"zip":77,"country":63,"countryCode":64,"cosmosGeoPoint":78,"geoPoint":82,"contacts":83},"Memorial Sloan Kettering Monmouth (Limited protocol activities)","Middletown","07748",{"type":66,"coordinates":79},[80,81],-74.11709,40.39428,{"lat":81,"lon":80},[84],{"name":45,"role":49,"phone":73,"phoneExt":21,"email":21},{"facility":86,"status":59,"city":87,"state":61,"zip":88,"country":63,"countryCode":64,"cosmosGeoPoint":89,"geoPoint":93,"contacts":94},"Memorial Sloan Kettering Bergen (Limited Protocol Activities)","Montvale","07645",{"type":66,"coordinates":90},[91,92],-74.02292,41.04676,{"lat":92,"lon":91},[95],{"name":45,"role":49,"phone":73,"phoneExt":21,"email":21},{"facility":97,"status":59,"city":98,"state":99,"zip":100,"country":63,"countryCode":64,"cosmosGeoPoint":101,"geoPoint":105,"contacts":106},"Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (Limited protocol activities)","Commack","New York","11725",{"type":66,"coordinates":102},[103,104],-73.29289,40.84288,{"lat":104,"lon":103},[107],{"name":45,"role":49,"phone":73,"phoneExt":21,"email":21},{"facility":109,"status":59,"city":110,"state":99,"zip":111,"country":63,"countryCode":64,"cosmosGeoPoint":112,"geoPoint":116,"contacts":117},"Memorial Sloan Kettering Westchester (Limited Protocol Activities)","Harrison","10604",{"type":66,"coordinates":113},[114,115],-73.71263,40.96899,{"lat":115,"lon":114},[118],{"name":45,"role":49,"phone":73,"phoneExt":21,"email":21},{"facility":120,"status":59,"city":99,"state":99,"zip":121,"country":63,"countryCode":64,"cosmosGeoPoint":122,"geoPoint":126,"contacts":127},"Memorial Sloan Kettering Cancer Center (All Protocol Activities)","10065",{"type":66,"coordinates":123},[124,125],-74.00597,40.71427,{"lat":125,"lon":124},[128],{"name":45,"role":49,"phone":73,"phoneExt":21,"email":21},{"facility":130,"status":59,"city":131,"state":99,"zip":132,"country":63,"countryCode":64,"cosmosGeoPoint":133,"geoPoint":137,"contacts":138},"Memorial Sloan Kettering Nassau (Limited Protocol Activities)","Uniondale","11553",{"type":66,"coordinates":134},[135,136],-73.59291,40.70038,{"lat":136,"lon":135},[139],{"name":45,"role":49,"phone":73,"phoneExt":21,"email":21},{"type":141,"investigatorFullName":21,"investigatorTitle":21,"investigatorAffiliation":21,"oldNameTitle":21,"oldOrganization":21},"SPONSOR","100472291","a-study-comparing-perioperative-stress-reduction-vs-standard-of-care-in-ovarian-cancer-preserve-100472291",false,"NCT05429970","A Study Comparing Perioperative Stress Reduction vs. Standard of Care in Ovarian Cancer (PRESERVE)","Perioperative Stress Reduction in Ovarian Cancer (PRESERVE Trial)-A Prospective Randomized Pilot Study","Inclusion Criteria:\n\n* Advanced (stage II-IV) epithelial ovarian, fallopian tube, or primary peritoneal carcinoma diagnosed on the basis of imaging, CA125, and clinical assessment\n* Scheduled to undergo exploratory laparotomy and PDS or IDS\n* Scheduled for surgery with at least 10 days of lead time, to allow the participant to take the β-blocker and COX2 inhibitor 7 days preoperatively\n* Age ≥18 years\n* ASA score of 1 to 3\n* Ability to understand the study objectives and procedures, comply with the protocol, and provide informed consent\n\nExclusion Criteria:\n\n* Chronic treatment with any β-blocker or COX inhibitor\n* Contraindication for β-blocker therapy (asthma, second- or third-degree atrioventricular block, sinus bradycardia, sick sinus syndrome, right-sided heart failure, pheochromocytoma, peripheral vascular disease)\n* Contraindication for COX2 inhibitor therapy (renal failure \\[creatinine level \\>1.5 mg\u002FdL\\], significant liver failure \\[known cirrhosis, bilirubin level \\>2\\], active peptic disease), or current use of oral anticoagulant)\n* Contraindication for regional epidural anesthesia\n* Chronic autoimmune disease\n* Active infection\n* Pregnant\n* Minimally invasive procedure\n* Participation in another clinical trial that interferes with this study","FEMALE","18 Years",{"count":152,"type":153},35,"ESTIMATED","INTERVENTIONAL",[156],"NA","The purpose of this study is to see if propranolol and etodolac along with mind-body resilience training\u002FMBRT and music therapy help participants who are experiencing physiological stress before, during, and after primary debulking surgery\u002FPDS or IDS and also if it's better than the standard-of-care approach (no intervention for reducing stress).",[159,160,161,162,163,164,165,166,167,168,169,170,171,172],"Ovarian Cancer","Ovarian Carcinoma","Stage II Ovary Cancer","Stage II Ovarian Cancer","Stage III Ovary Cancer","Stage III Ovarian Cancer","Stage IV Ovary Cancer","Stage IV Ovarian Cancer","Epithelial Ovarian Cancer","Fallopian Tube Cancer","Stage II Fallopian Tube Cancer","Stage III Fallopian Tube Cancer","Stage IV Fallopian Tube Cancer","Primary Peritoneal Carcinoma",[174,175,176,29,177,178,167,168,172],"ovarian cancer","propranolol","etodolac","mind-body resilience training","music therapy","2026-06-30",{"date":181,"type":182},"2026-07-01","ACTUAL",{"date":184,"type":182},"2022-06-17",{"date":186,"type":153},"2027-06-17",{"name":5,"class":6},7]