[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100594468":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":22,"centralContacts":23,"locations":22,"responsibleParty":33,"collaborators":37,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":22,"eligibilityCriteria":47,"healthyVolunteers":48,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":22,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":67,"whyStopped":22,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":22},{"fullName":5,"class":6},"Massachusetts General Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Single arm, respiratory mechanics and adipose distribution in two body positions","EXPERIMENTAL","A total of 20 healthy volunteers will undergo assessments of respiratory mechanics in the supine and prone position. Then, the same subjects will undergo CT scans of the lungs in both positions. Body positions will be randomly applied for 15 minutes each.",[13],"Procedure: Body positioning",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Body positioning","Each subject will breathe in both the supine and prone positions, randomly applied for 15 minutes each. The procedure will be performed twice: once for the assessment of respiratory physiology, and once for computed tomography acquisition.",[9],[21],"Supine and prone",null,[24,29],{"name":25,"role":26,"phone":27,"phoneExt":22,"email":28},"Maurizio Cereda, MD","CONTACT","16176430987","mcereda@mgh.harvard.edu",{"name":30,"role":26,"phone":31,"phoneExt":22,"email":32},"Lorenzo Berra, MD","617 724 0743","LBERRA@mgh.harvard.edu",{"type":34,"investigatorFullName":35,"investigatorTitle":36,"investigatorAffiliation":5,"oldNameTitle":22,"oldOrganization":22},"SPONSOR_INVESTIGATOR","Maurizio F. Cereda, MD","Associate Professor of Anesthesia",[38],{"name":39,"class":40},"National Institutes of Health (NIH)","NIH","100594468","a-study-of-body-fat-distribution-and-airway-mechanics-in-healthy-adults-100594468",false,"NCT07019831","A Study of Body Fat Distribution and Airway Mechanics in Healthy Adults","Imaging the Respiratory Effects of Truncal Adiposity in Healthy Subjects","Inclusion Criteria\n\n• Healthy subjects older than 18 years and younger than 80.\n\nExclusion Criteria\n\n* Pre-existing cardiopulmonary disease\n* history of tobacco or ecigarette smoking",true,"ALL","18 Years","80 Years",{"count":53,"type":54},20,"ESTIMATED","INTERVENTIONAL",[57],"NA","This study investigates how body fat distribution affects airway closure and lung mechanics in healthy adults. Using Electrical Impedance Tomography (EIT), esophageal manometry, and computed tomography (CT), we aim to characterize how varying BMI and fat topography influence regional ventilation and airway collapse in supine and prone positions. Healthy volunteers with a range of BMIs will undergo a 2-hour imaging session with noninvasive and minimally invasive monitoring.",[60],"Healthy Volunteers Only",[62,63,64,65,66],"obesity","electrical impedance tomography","computed tomography","esophageal manometry","airway geometry","NOT_YET_RECRUITING","2025-06-16",{"date":70,"type":71},"2025-06-18","ACTUAL",{"date":73,"type":54},"2028-01-01",{"date":75,"type":54},"2030-06-30",{"name":35,"class":6}]