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Clinico Univ. de Valladolid","Valladolid","47003",{"type":34,"coordinates":578},[579,580],-4.72353,41.65541,{"lat":580,"lon":579},{"facility":583,"status":28,"city":584,"state":10,"zip":585,"country":586,"countryCode":587,"cosmosGeoPoint":588,"geoPoint":592,"contacts":10},"Royal United Hospital","Bath","BA1 3NG","United Kingdom","UK",{"type":34,"coordinates":589},[590,591],-2.36172,51.3751,{"lat":591,"lon":590},{"facility":594,"status":28,"city":595,"state":10,"zip":596,"country":586,"countryCode":587,"cosmosGeoPoint":597,"geoPoint":601,"contacts":10},"Eastbourne District General Hospital","Eastbourne","BN21 2UD",{"type":34,"coordinates":598},[599,600],0.28453,50.76871,{"lat":600,"lon":599},{"facility":603,"status":28,"city":604,"state":10,"zip":605,"country":586,"countryCode":587,"cosmosGeoPoint":606,"geoPoint":610,"contacts":10},"Royal Surrey County Hospital NHS Trust","Guildford","GU2 7XX",{"type":34,"coordinates":607},[608,609],-0.57427,51.23536,{"lat":609,"lon":608},{"facility":612,"status":28,"city":613,"state":10,"zip":614,"country":586,"countryCode":587,"cosmosGeoPoint":615,"geoPoint":619,"contacts":10},"New Cross Hospital","Heath Town","WV10 0QP",{"type":34,"coordinates":616},[617,618],-2.1027,52.5933,{"lat":618,"lon":617},{"facility":621,"status":28,"city":622,"state":10,"zip":623,"country":586,"countryCode":587,"cosmosGeoPoint":624,"geoPoint":628,"contacts":10},"Royal Marsden Hospital","London","SW3 6JJ",{"type":34,"coordinates":625},[626,627],-0.12574,51.50853,{"lat":627,"lon":626},{"facility":630,"status":28,"city":631,"state":10,"zip":632,"country":586,"countryCode":587,"cosmosGeoPoint":633,"geoPoint":637,"contacts":10},"The Christie NHS Foundation Trust Christie Hospital","Manchester","M20 4BX",{"type":34,"coordinates":634},[635,636],-2.23743,53.48095,{"lat":636,"lon":635},{"facility":639,"status":28,"city":640,"state":10,"zip":641,"country":586,"countryCode":587,"cosmosGeoPoint":642,"geoPoint":646,"contacts":10},"Royal Marsden Hospital (Sutton)","Sutton","SM2 5PT",{"type":34,"coordinates":643},[644,645],-0.2,51.35,{"lat":645,"lon":644},{"type":648,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100610677","a-study-of-clinical-outcomes-in-participants-with-egfr-mutated-advanced-non-small-cell-lung-cancer-nsclc-in-a-real-world-setting-100610677",false,"NCT07230691","A Study of Clinical Outcomes in Participants With EGFR Mutated Advanced Non-Small Cell Lung Cancer (NSCLC) in a Real-World Setting","Prospective, Multi Country, Observational Study of Clinical Outcomes in EGFR-mutated, Advanced Non-Small Cell Lung Cancer (NSCLC) Patients Treated With Approved Amivantamab-containing Regimens Under Standard Clinical Practice","LEPIDOPTERA","Inclusion Criteria:\n\n* Participant has a confirmed diagnosis of common epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) (EGFR exon 19 deletions or exon 21 L858R substitution) and is eligible for an amivantamab-containing regimen per the judgment of the treating physician and in alignment with the approved amivantamab indications and recommended prophylactic and reactive medication as described in the local specific summary of product characteristics (SmPC) for amivantamab\n* Participants or their legally acceptable representative, where applicable, must sign a participation agreement\u002FInformed consent form (ICF) allowing source data verification in accordance with local requirements\n* Participant is being planned to be initiated with an amivantamab-containing regimen for the first time within 4 weeks following the visit for start of data collection\n* Decision to administer an amivantamab-containing regimen has been made prior to participant's enrollment in the study and is separate from the physician's decision to include the participant in the current study\n\nExclusion criteria:\n\n* At the time of the initiation of the amivantamab-containing regimen, the participant is receiving an active systemic anticancer treatment for advanced NSCLC that is not included in the locally approved combination regimen with amivantamab (regardless of whether it is part of an interventional study). One cycle of platinum-based chemotherapy (for example, carboplatin-pemetrexed) is permitted prior to the first dose of amivantamab in a 1L while awaiting biopsy results\n* Participant has received prior treatment with amivantamab in a clinical trial or for compassionate use\n* Participants who are not receiving amivantamab but are being treated with a biosimilar or a non-original biologic agent\n* Participants with conditions listed in the contraindications of the SmPC for amivantamab or other agents essential for the applicable amivantamab-containing treatment regimen (lazertinib\u002F platinum\u002F pemetrexed)","ALL","18 Years",{"count":660,"type":661},380,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to describe the clinical and health-related outcomes of amivantamab-containing regimens for the treatment of common epidermal growth factor receptor (EGFR) mutated non-small cell lung cancer (NSCLC; most common type of lung cancer) in a real-world setting. Metastatic NSCLC is when this disease spreads to other parts of body. NSCLC may occur due to mutations (changes) in many genes including epidermal growth factor receptor (EGFR).",[665],"Carcinoma, Non-Small-Cell Lung","2026-06-04",{"date":668,"type":669},"2026-06-05","ACTUAL",{"date":671,"type":669},"2025-12-03",{"date":673,"type":661},"2030-12-17",{"name":5,"class":6},70]