[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100585745":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":32,"centralContacts":36,"locations":42,"responsibleParty":127,"collaborators":10,"id":129,"slug":130,"hasResults":131,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":10,"eligibilityCriteria":135,"healthyVolunteers":131,"sex":136,"minAge":137,"maxAge":10,"enrollmentInfo":138,"targetDuration":141,"studyType":142,"phases":10,"briefSummary":143,"conditions":144,"keywords":146,"overallStatus":45,"whyStopped":10,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":160},{"fullName":5,"class":6},"Amicus Therapeutics","INDUSTRY",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Migalastat-treated",null,"Migalastat-treated patients at the time of enrollment who started the treatment within the 24 months prior to enrollment.",[13],"Drug: migalastat HCl",{"label":15,"type":10,"description":16,"interventionNames":17},"ERT-treated","Patients receiving ERT at the time of enrollment who started the treatment within the 24 months prior to enrollment.",[18],"Drug: ERT",{"label":20,"type":10,"description":21,"interventionNames":10},"Untreated","Untreated patients at the time of enrollment; these patients must never have been on therapy for Fabry disease prior to enrollment into the study and must meet criteria for receiving treatment with migalastat.",[23,28],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":10},"DRUG","migalastat HCl","Non-interventional study of participants receiving migalastat HCl 150 mg",[9],{"type":24,"name":29,"description":30,"armGroupLabels":31,"otherNames":10},"ERT","Non-interventional study of participants receiving enzyme replacement therapy",[15],[33],{"name":34,"affiliation":5,"role":35},"Clinical Research","STUDY_DIRECTOR",[37],{"name":38,"role":39,"phone":40,"phoneExt":10,"email":41},"Amicus Therapeutics Patient Advocacy","CONTACT","609-662-2000","patientadvocacy@amicusrx.com",[43,57,67,77,88,97,107,117],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":10},"UAB Nephrology Research Clinic at Paula Building","RECRUITING","Birmingham","Alabama","35233","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-86.80249,33.52066,{"lat":55,"lon":54},{"facility":58,"status":45,"city":59,"state":60,"zip":61,"country":49,"countryCode":50,"cosmosGeoPoint":62,"geoPoint":66,"contacts":10},"Arkansas Children's Hospital","Little Rock","Arkansas","72202",{"type":52,"coordinates":63},[64,65],-92.28959,34.74648,{"lat":65,"lon":64},{"facility":68,"status":45,"city":69,"state":70,"zip":71,"country":49,"countryCode":50,"cosmosGeoPoint":72,"geoPoint":76,"contacts":10},"Emory Genetics","Atlanta","Georgia","30322",{"type":52,"coordinates":73},[74,75],-84.38798,33.749,{"lat":75,"lon":74},{"facility":78,"status":79,"city":80,"state":81,"zip":82,"country":49,"countryCode":50,"cosmosGeoPoint":83,"geoPoint":87,"contacts":10},"Washington University School of Medicine","NOT_YET_RECRUITING","St Louis","Missouri","63110",{"type":52,"coordinates":84},[85,86],-90.19789,38.62727,{"lat":86,"lon":85},{"facility":89,"status":79,"city":90,"state":90,"zip":91,"country":49,"countryCode":50,"cosmosGeoPoint":92,"geoPoint":96,"contacts":10},"New York-Presbyterian Morgan Stanley Children's Hospital - Columbia University Medical Center","New York","10032",{"type":52,"coordinates":93},[94,95],-74.00597,40.71427,{"lat":95,"lon":94},{"facility":98,"status":79,"city":99,"state":100,"zip":101,"country":49,"countryCode":50,"cosmosGeoPoint":102,"geoPoint":106,"contacts":10},"UPMC Children's Hospital of Pittsburgh","Pittsburgh","Pennsylvania","15224",{"type":52,"coordinates":103},[104,105],-79.99589,40.44062,{"lat":105,"lon":104},{"facility":108,"status":45,"city":109,"state":110,"zip":111,"country":49,"countryCode":50,"cosmosGeoPoint":112,"geoPoint":116,"contacts":10},"Renal Disease Research Institute","Dallas","Texas","75204",{"type":52,"coordinates":113},[114,115],-96.80667,32.78306,{"lat":115,"lon":114},{"facility":118,"status":45,"city":119,"state":120,"zip":121,"country":49,"countryCode":50,"cosmosGeoPoint":122,"geoPoint":126,"contacts":10},"Lysosomal and Rare Disorders Research and Treatment Center, Inc.","Fairfax","Virginia","22030",{"type":52,"coordinates":123},[124,125],-77.30637,38.84622,{"lat":125,"lon":124},{"type":128,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100585745","a-study-of-patients-with-fabry-disease-us-specific-100585745",false,"NCT06906367","A Study of Patients With Fabry Disease (US Specific)","A Prospective, Observational Study of Patients With Fabry Disease (US Specific)","I. Migalastat-treated patients (Commercial only participants)\n\n1. Patients with Fabry disease 18 years or older with amenable GLA variants who have commenced commercial migalastat treatment within 24 months preceding enrollment, who have an eGFR greater than or equal to 30 mL\u002Fmin\u002F1.73 m2 at the time of enrollment and are still taking migalastat at the time of enrollment, or who are starting migalastat at the time of enrollment, excluding those who participated in a prior migalastat clinical trial\n2. Patients who show a decline in their Fabry disease symptomatology based on any of the following:\n\n   1. a decrease in annualized rate of decline eGFRCKD-EPI of ≥ 2 mL\u002Fmin\u002F1.73 m2 during the 2 years prior to enrollment\n   2. microalbuminuria\u002Fmacroalbuminuria (≥ 30 mg\u002F24 h or ≥ 20 mg on first morning urine) or urine ACR of ≥ 30 mg\u002Fg (via spot urine collection) at any time prior to or at enrollment\n   3. proteinuria (\\> 0.5 g\u002Fg UPCR) any time prior to or at enrollment\n   4. males with classic Fabry disease phenotype\n\nII. Migalastat-treated patients who are not considered to be in renal decline (Commercial migalastat users only)\n\n1\\. Patients with Fabry disease with amenable GLA variants who have been on commercial migalastat regardless of the duration of treatment\n\nIII. Migalastat-treated patients (Prior clinical trial participants)\n\n1. Patients with Fabry disease 18 years or older who had commenced treatment with migalastat while in a clinical trial and were exposed to treatment for at least 24 months preceding enrollment, who have an eGFR greater than or equal to 30 mL\u002Fmin\u002F1.73 m2 at the time of enrollment, and who are still taking migalastat at the time of enrollment, having switched to commercial product\n\nIV. Untreated patients\n\n1. Patients with Fabry disease 18 years or older with amenable GLA variants, who have never been on treatment for Fabry disease, who have an eGFR greater than or equal to 30 mL\u002Fmin\u002F1.73 m2 at the time of enrollment, and who meet local treatment guidelines for Fabry disease\n2. Patients who show a decline in their Fabry disease symptomatology based on any of the following:\n\n   1. a decrease in annualized rate of decline eGFRCKD-EPI of ≥ 2 mL\u002Fmin\u002F1.73 m2 during the 2 years prior to enrollment\n   2. microalbuminuria\u002Fmacroalbuminuria (≥ 30 mg\u002F24 h or ≥ 20 mg on first morning urine) or urine ACR of ≥ 30 mg\u002Fg (via spot urine collection) at any time prior to or at enrollment\n   3. proteinuria (\\> 0.5 g\u002Fg UPCR) any time prior to or at enrollment\n   4. males with classic Fabry disease phenotype\n\nV. ERT-treated patients\n\n1. Patients with Fabry disease 18 years or older who have commenced ERT within 24 months preceding enrollment, who have an eGFR greater than or equal to 30 mL\u002Fmin\u002F1.73 m2 at the time of enrollment and are still being treated with ERT at the time of enrollment, and who have amenable GLA variants\n2. Patients who show a decline in their Fabry disease symptomatology based on any of the following:\n\n   1. a decrease in eGFRCKD-EPI annualized rate of decline of ≥ 2 mL\u002Fmin\u002F1.73 m2 during the 2 years prior to enrollment\n   2. microalbuminuria\u002Fmacroalbuminuria (≥ 30 mg\u002F24 h or ≥ 20 mg on first morning urine) or urine ACR of ≥ 30 mg\u002Fg (via spot urine collection) at any time prior to or at enrollment\n   3. proteinuria (\\> 0.5 g\u002Fg UPCR) any time prior to or at enrollment\n   4. males with classic Fabry disease phenotype\n\nAll patients 1. All treated and untreated patients with Fabry disease who are enrolled in the study must be able to understand and provide written informed consent or assent.\n\nExclusion Criteria\n\n1\\. Patients who currently are participating in a clinical trial of any investigational medicinal product or device at the time of enrollment","ALL","18 Years",{"count":139,"type":140},450,"ESTIMATED","5 Years","OBSERVATIONAL","This is an observational study to evaluate the effects of treatment on long-term effectiveness, safety, and health-related quality of life (HRQOL) in patients with Fabry disease, with a main focus on migalastat.",[145],"Fabry Disease",[147,148,149,150],"migalastat","AT1001","registry","lysosomal disease","2026-05-14",{"date":153,"type":154},"2026-05-18","ACTUAL",{"date":156,"type":154},"2026-02-13",{"date":158,"type":140},"2032-06",{"name":5,"class":6},8]