[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100516620":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":45,"centralContacts":10,"locations":49,"responsibleParty":70,"collaborators":10,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":10,"eligibilityCriteria":79,"healthyVolunteers":75,"sex":80,"minAge":81,"maxAge":10,"enrollmentInfo":82,"targetDuration":10,"studyType":85,"phases":10,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":52,"whyStopped":10,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Sequelae group",null,"COVID-19 convalescents that recover from prior severe acute diseases requiring hospitalization and who will be at high risk of chronic lung sequelae (with an estimate of \\>50% having moderate to severe sequelae based on current literature)",[13,14,15,16,17],"Procedure: Bronchoscopies and Bronchoalveolar Lavages (BALs)","Diagnostic Test: Chest Tomography (CT)","Diagnostic Test: Electrocardiogram (ECG)","Diagnostic Test: Pulmonary function tests (PFTs)","Diagnostic Test: 6 minute walk test (6MWT)",{"label":19,"type":10,"description":20,"interventionNames":21},"Recovery group","Age and gender matched individuals who had mild SARS-CoV-2 infection and experienced complete resolution of symptoms",[13,14,15,16,17],[23,28,33,37,41],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":10},"PROCEDURE","Bronchoscopies and Bronchoalveolar Lavages (BALs)","Bronchoscopies use a thin, lighted tube, which enters through the mouth or nose and moves down the throat to the airways to look at the lungs. BALs are done during bronchoscopies to collect samples from the lungs for testing. During this procedure, a saline solution is put through the tube to wash the airways and collect a fluid sample.",[19,9],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":10},"DIAGNOSTIC_TEST","Chest Tomography (CT)","X-ray to create images of the bones and internal organs of the body",[19,9],{"type":29,"name":34,"description":35,"armGroupLabels":36,"otherNames":10},"Electrocardiogram (ECG)","Measures the electrical activity of the heart by using sticky pads that are placed on your chest and limbs.",[19,9],{"type":29,"name":38,"description":39,"armGroupLabels":40,"otherNames":10},"Pulmonary function tests (PFTs)","Testing to measure how well lungs are working",[19,9],{"type":29,"name":42,"description":43,"armGroupLabels":44,"otherNames":10},"6 minute walk test (6MWT)","Walking test to see how well the lungs function with exercise over 6 minutes",[19,9],[46],{"name":47,"affiliation":5,"role":48},"Robert Vassallo, MD","PRINCIPAL_INVESTIGATOR",[50],{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"Mayo Clinic Minnesota","RECRUITING","Rochester","Minnesota","55905","United States","US",{"type":59,"coordinates":60},"Point",[61,62],-92.4699,44.02163,{"lat":62,"lon":61},[65],{"name":66,"role":67,"phone":68,"phoneExt":10,"email":69},"Chris Roberts","CONTACT","800-753-1606","roberts.chris@mayo.edu",{"type":48,"investigatorFullName":71,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Robert Vassallo","Principal Investigator","100516620","a-study-of-post-covid-19-mechanisms-for-chronic-lung-sequelae-100516620",false,"NCT06006884","A Study of Post COVID-19 Mechanisms for Chronic Lung Sequelae","Uncover Mechanisms Underlying the Development of Chronic Lung Sequelae Post COVID-19","Inclusion Criteria:\n\nFor the Sequelae Group\n\n* Age ≥18 years at screening, PCR confirmed COVID19 illness (+PCR defines day 0 of illness), hospitalization for COVID-19, absence of pre-existing history of interstitial lung disease, or significant other lung disease.\n* Severity of illness will be categorized as moderate disease (supplemental oxygen need 1-8L at any time during hospitalization), severe disease (need for high flow oxygen delivery ≥8L at any time during hospitalization) and critical illness (need for ICU admission or mechanical ventilation).\n\nControl Recovery Group\n\n* Age ≥18 years at screening\n* PCR confirmed COVID-19 cases who had nonsymptomatic or mild acute infection that do not require hospitalization 7,48,49\n* Absence of pre-existing history of interstitial lung disease, or significant other lung disease, absence of any ongoing respiratory and systemic symptoms.\n\nExclusion Criteria:\n\n* Inability to provide informed consent, evidence of pre-existing interstitial lung disease or chronic lung disease;\n* Active cigarette smoking, vaping or other inhalation use.\n* Immunocompromised host status due to ongoing therapy with methotrexate, CellCept, azathioprine, rituximab, cyclophosphamide or other biologic agents;\n* \\> 20 pack year smoking history.\n* History of chemotherapy or radiation therapy in the last two years; and pregnancy.","ALL","18 Years",{"count":83,"type":84},67,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to understand why some people experience long term effects, such as shortness of breath and fatigue, after a severe COVID-19 infection",[88],"COVID-19",[88,90,91,92,93],"SARS-CoV-2","Long COVID","chronic lung sequelae","post-acute","2026-05-01",{"date":96,"type":97},"2026-05-07","ACTUAL",{"date":99,"type":97},"2024-01-10",{"date":101,"type":84},"2027-08",{"name":5,"class":6},1]