[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100590567":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":10,"centralContacts":20,"locations":26,"responsibleParty":45,"collaborators":10,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":10,"eligibilityCriteria":52,"healthyVolunteers":49,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":10,"studyType":59,"phases":10,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":29,"whyStopped":10,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"Xinhua Hospital, Shanghai Jiao Tong University School of Medicine","OTHER",[8,13],{"label":9,"type":10,"description":10,"interventionNames":11},"Oral Frailty Group",null,[12],"Other: Oral Frailty",{"label":14,"type":10,"description":10,"interventionNames":10},"Non-Oral Frailty Group",[16],{"type":6,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"Oral Frailty","The exposure factor is the presence of oral frailty in patients before surgery, and oral frailty is evaluated using a scale.",[9],[21],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Aimin Shao, master","CONTACT","18796080248","1224103064@qq.com",[27],{"facility":28,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"Shanghai Xinhua hospital","RECRUITING","Shanghai","Shanghai Municipality","200092","China","CN",{"type":36,"coordinates":37},"Point",[38,39],121.45806,31.22222,{"lat":39,"lon":38},[42],{"name":43,"role":23,"phone":44,"phoneExt":10,"email":10},"Jinsong Li Li","021-25076143",{"type":46,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100590567","a-study-on-the-correlation-between-oral-health-and-delirium-in-surgical-inpatients-100590567",false,"NCT06969092","A Study on the Correlation Between Oral Health and Delirium in Surgical Inpatients","Inclusion Criteria:\n\n* Patients aged ≥18 years scheduled for elective cardiac or thoracic surgery requiring endotracheal intubation.\n\nPatients without consciousness impairment, able to cooperate with the investigation.\n\nPatients or their legal guardians informed about the study's purpose, methodology, and content, with signed informed consent forms.\n\nExclusion Criteria:\n\n* Patients with pre-existing oral conditions (e.g., xerostomia, oral mucosal lesions) prior to mechanical ventilation.\n\nPatients with a history of radiotherapy, chemotherapy, or corticosteroid use before surgery.\n\nPatients experiencing intraoperative mortality.","ALL","18 Years","90 Years",{"count":57,"type":58},550,"ESTIMATED","OBSERVATIONAL","Delirium is a clinical syndrome characterized by acute attention deficits, altered consciousness, and fluctuating cognitive dysfunction, typically triggered by multifactorial causes such as physical illness, medication use, or postoperative stress . As the most common complication in hospitalized patients, delirium is highly prevalent among elderly surgical populations, with postoperative delirium (POD) occurring in 7.5%-27.5% of cases, and rates rising to 50%-70% in intensive care unit (ICU) patients . Its onset is closely associated with poor prognoses, including long-term postoperative cognitive decline , increased mortality, prolonged hospitalization, and elevated healthcare costs (annual costs in the United States ranging from 38billionto152 billion) . Early prevention and screening of POD are therefore critical to improving patient outcomes and reducing healthcare burdens.\n\nSurgical patients' oral health issues exhibit multifactorial pathogenesis: intrinsic factors (e.g., age-related tooth loss, malnutrition-induced mucosal repair impairment, and chewing dysfunction due to reduced skeletal muscle mass) and iatrogenic factors (e.g., endotracheal intubation trauma, salivary secretion suppression from analgesics, and inadequate perioperative oral care). Poor oral health in hospitalized patients is often attributable to aging, physical dependence, cognitive decline, malnutrition, low skeletal muscle mass\u002Fstrength, and comorbidities. The recently proposed concept of \"Oral Frailty\"-a progressive decline in oral structure and function-strongly predicts physical frailty, dysphagia, malnutrition, long-term care needs, and mortality in community-dwelling older adults\n\nThe impact of oral health on cognitive function may involve three pathways :\n\nMechanical pathway: Tooth loss disrupts masticatory motor function, reduces cerebral blood flow, and diminishes afferent stimulation from peripheral receptors (e.g., periodontal ligaments), leading to weakened neural connectivity and regional brain atrophy.\n\nNeurodegenerative pathway: Tooth loss accelerates neuronal damage via apoptosis and mitophagy, increasing amyloid-beta deposition in the brain.\n\nInflammatory\u002Fmetabolic pathway: Systemic inflammation, metabolic dysregulation, microbial-gut-brain axis interactions, and activation of microglia\u002Fastrocytes drive neuroinflammatory cascades in the central nervous system.\n\nGiven these connections, oral frailty may act as an independent risk factor distinct from general frailty and a potential contributor to POD. These findings suggest that oral frailty could serve as a unique biomarker for perioperative neurocognitive disorders, mediating their pathogenesis. Systematic investigation into the spatiotemporal relationship and mechanisms linking oral health to POD in surgical patients holds significant clinical value for developing multimodal prevention strategies.",[62],"Oral Health",[62,17,64,65,66,67,68],"Surgical","Surgery","Delirium","Endotracheal Intubation","Cognitive Function","2025-05-06",{"date":71,"type":72},"2025-05-13","ACTUAL",{"date":74,"type":58},"2025-05-25",{"date":76,"type":58},"2026-03-25",{"name":5,"class":6},1]