[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100266135":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":38,"centralContacts":43,"locations":52,"responsibleParty":70,"collaborators":74,"id":81,"slug":82,"hasResults":83,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":33,"eligibilityCriteria":87,"healthyVolunteers":83,"sex":88,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":33,"studyType":94,"phases":95,"briefSummary":97,"conditions":98,"keywords":100,"overallStatus":55,"whyStopped":33,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"Sun Yat-sen University","OTHER",[8,14,19,23],{"label":9,"type":10,"description":11,"interventionNames":12},"High-level tumor budding group with CLND","EXPERIMENTAL","Resection for primary lesion and cervical lymph node dissection (CLND) are performed in the early-stage oral squamous cell carcinoma which tumor budding is a high level.",[13],"Procedure: Resection for primary lesion and cervical lymph node dissection",{"label":15,"type":10,"description":16,"interventionNames":17},"High-level tumor budding group without CLND","Only resection for primary lesion is performed in the early-stage oral squamous cell carcinoma which tumor budding is a high level.",[18],"Procedure: Resection for primary lesion only",{"label":20,"type":10,"description":21,"interventionNames":22},"Low-level tumor budding group with CLND","Resection for primary lesion and cervical lymph node dissection (CLND) are performed in the early-stage oral squamous cell carcinoma which tumor budding is a low level.",[13],{"label":24,"type":10,"description":25,"interventionNames":26},"Low-level tumor budding group without CLND","Only resection for primary lesion is performed in the early-stage oral squamous cell carcinoma which tumor budding is a low level.",[18],[28,34],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"PROCEDURE","Resection for primary lesion and cervical lymph node dissection","Resection for primary lesion and cervical lymph node dissection are performed in the early-stage oral squamous cell carcinoma.",[9,20],null,{"type":29,"name":35,"description":36,"armGroupLabels":37,"otherNames":33},"Resection for primary lesion only","Only resection for primary lesion is performed in the early-stage oral squamous cell carcinoma.",[15,24],[39],{"name":40,"affiliation":41,"role":42},"Jinsong Hou, PhD","Guanghua School of Stomatology, Hospital of Stomatolagy Sun Yat-sen University","STUDY_DIRECTOR",[44,48],{"name":40,"role":45,"phone":46,"phoneExt":33,"email":47},"CONTACT","86-13825141651","houjsgz@aliyun.com",{"name":49,"role":45,"phone":50,"phoneExt":33,"email":51},"Cheng Wang, PhD","86-13760853366","drwangcheng@outlook.com",[53],{"facility":54,"status":55,"city":56,"state":57,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"Guanghua School of Stomatolagy, Hospital of Stomatology Sun Yat-sen University","RECRUITING","Guangzhou","Guangdong","510055","China","CN",{"type":62,"coordinates":63},"Point",[64,65],113.25,23.11667,{"lat":65,"lon":64},[68,69],{"name":40,"role":45,"phone":46,"phoneExt":33,"email":47},{"name":49,"role":45,"phone":50,"phoneExt":33,"email":51},{"type":71,"investigatorFullName":72,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":33,"oldOrganization":33},"SPONSOR_INVESTIGATOR","Jinsong Hou","Vice Director",[75,77,79],{"name":76,"class":6},"First Affiliated Hospital, Sun Yat-Sen University",{"name":78,"class":6},"Second Affiliated Hospital, Sun Yat-Sen University",{"name":80,"class":6},"Hospital of Stomatology, Sun Yat-Sen University","100266135","a-study-on-tumor-budding-guiding-individualized-surgical-planning-of-early-stage-oral-squamous-cell-carcinoma-100266135",false,"NCT02743832","A Study on Tumor Budding Guiding Individualized Surgical Planning of Early-stage Oral Squamous Cell Carcinoma.","A Randomized，Multicenter，Prospectie，Controlled Clinical Study on Tumor Budding Guiding Individualized Surgical Planning of Early-stage Oral Squamous Cell Carcinoma.","Inclusion Criteria:\n\n1. Han race;\n2. Oral squamous cell carcinoma is confirmed by pathology;\n3. The section of oral squamous cell carcinoma including primary two-thirds prior to the tongue, buccal mucosa， gingiva， mouth floor， hard palate mucosa;\n4. The primary lesion is no more than 4cm;\n5. Do not find cervical lymph node metastases and distant metastasis in the clinical examination including physical examination and MRI;\n6. Patients and families agree to participate in the study;\n7. Patients do not have cognitive disorders.\n\nExclusion Criteria:\n\n1. Do not meet the inclusion criteria;\n2. The primary lesion is more than 4cm or invade adjacent tissues;\n3. Do not review on schedule;\n4. Patients receive not only surgical procedures, but other antineoplastic treatment;\n5. There are serious adverse events after operation;\n6. Patients quit the study voluntarily;\n7. Patients quit the study because of physical condition.","ALL","20 Years","70 Years",{"count":92,"type":93},524,"ESTIMATED","INTERVENTIONAL",[96],"NA","The purpose of this study is to determine whether cervical lymph node dissection is necessarily performed in the presence of early-stage oral squamous cell carcinoma.",[99],"Carcinoma, Squamous Cell",[101,102,103],"Oral squamous cell carcinoma","Tumor budding","Cervical lymph node dissection","2026-04-24",{"date":106,"type":107},"2026-04-30","ACTUAL",{"date":109,"type":93},"2026-05-04",{"date":111,"type":93},"2027-06-30",{"name":72,"class":6},1]