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has been informed of all pertinent aspects of the study.\n\nExclusion Criteria:\n\n* Presence of clinical findings suggestive of Crohn's disease.\n* Severe extensive colitis evidenced by:\n\n  1. Physician judgement that the patient is likely to require hospitalization for medical or surgical intervention of any kind for UC (eg, colectomy) within 12 weeks.\n  2. Current evidence of acute severe UC, fulminant colitis, or toxic megacolon 3. Patients with a stoma or planned UC surgical intervention requiring hospitalization.\n\n     4\\. Prior\u002FConcomitant Therapy:\n\n  \u003C!-- -->\n\n  1. any previous exposure to etrasimod including participation in the etrasimod clinical program.\n  2. any co-medication with one of the following conventional therapies: methotrexate or a thiopurine (azathioprine, mercaptopurine or tioguanine) or with any of the following advanced therapies for UC: biologics (a TNF, integrin or cytokine antagonist); JAK inhibitors (filgotinib, tofacitinib or upadacitinib) or with any other S1P receptor modulator.\n* Not owning a digital device with internet connection and\u002For not willing to complete health questionnaires on this device or not capable of using the health questionnaire collection tool.\n* Investigator site staff or Pfizer employees directly involved in the conduct of the study, site staff otherwise supervised by the investigator, and their respective family.","ALL","18 Years","64 Years",{"count":367,"type":368},360,"ESTIMATED","OBSERVATIONAL","The purpose of this real world non-interventional study is to learn about the effects of etrasimod as treatment for patients with moderate to severe ulcerative colitis.\n\nPatients will be treated according to standard of care and will only be included in the study if etrasimod is the best treatment choice according to the treating physician. Additionally, patients have to be between 18 and 65 years of age and should not have taken etrasimod in the past.\n\nAll patients will be prescribed etrasimod according to standard of care. Assessments will be conducted according to standard of care with the exception of health questionnaires which will be completed by the patients online on their own device.\n\nThe study duration is 52 weeks with 28 days of safety follow-up. Patients will visit their treating physician as they would if they were not enrolled in the study. 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