[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100596619":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":22,"centralContacts":26,"locations":34,"responsibleParty":55,"collaborators":10,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":10,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":10,"enrollmentInfo":66,"targetDuration":10,"studyType":69,"phases":10,"briefSummary":70,"conditions":71,"keywords":10,"overallStatus":37,"whyStopped":10,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Biogen","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Zuranolone",null,"Participants who are prescribed zuranolone for PPD and are filling zuranolone through a consumer value store (CVS) specialty pharmacy will be contacted through email or the call center for enrollment in the study.",[13],"Drug: Zuranolone",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"DRUG","Administered as specified in the treatment arm",[9],[20,21],"Zurzuvae","BIIB125",[23],{"name":24,"affiliation":5,"role":25},"Medical Director","STUDY_DIRECTOR",[27,32],{"name":28,"role":29,"phone":30,"phoneExt":10,"email":31},"US Biogen Clinical Trial Center","CONTACT","866-633-4636","clinicaltrials@biogen.com",{"name":33,"role":29,"phone":10,"phoneExt":10,"email":31},"Global Biogen Clinical Trial Center",[35],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"CVS Health","RECRUITING","Woonsocket","Rhode Island","02895","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-71.51478,42.00288,{"lat":47,"lon":46},[50,52],{"name":10,"role":29,"phone":51,"phoneExt":10,"email":10},"800-746-7287",{"name":53,"role":54,"phone":10,"phoneExt":10,"email":10},"Laura Lupton","PRINCIPAL_INVESTIGATOR",{"type":56,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100596619","a-study-to-learn-more-about-how-zuranolone-affects-postpartum-depression-symptoms-in-participants-who-took-it-within-1-year-after-the-end-of-their-pregnancy-100596619",false,"NCT07047820","A Study to Learn More About How Zuranolone Affects Postpartum Depression Symptoms in Participants Who Took it Within 1 Year After The End of Their Pregnancy","Prospective, Observational Survey Study Assessing Effectiveness of Zuranolone in Improving PPD Symptoms in the Real-world Setting","Key Inclusion Criteria:\n\n* Adults who were prescribed and had one successful fill for zuranolone within 12 months following end of pregnancy for the treatment of PPD from June 2025 to May 2026 through CVS Specialty Pharmacy.\n* Currently reside in the United States.\n* Able to complete the questionnaires independently.\n\nKey Exclusion Criteria:\n\n* Prior fill of zuranolone or brexanolone in last 12 months.\n* Participants with 2 or more doses of zuranolone at the time of screening.\n* Current or history of bipolar disorder.\n* Failure to complete baseline surveys prior to 2nd dose of zuranolone.\n* Pregnancy that ended more than 12 months ago.\n\nOther protocol-defined Inclusion\u002FExclusion criteria may apply.","FEMALE","18 Years",{"count":67,"type":68},200,"ESTIMATED","OBSERVATIONAL","In this study, researchers will learn more about how zuranolone affects the symptoms of postpartum depression, also known as PPD. Zuranolone is a drug that healthcare professionals can prescribe for adults with PPD. After giving birth, adults with PPD can suffer from symptoms such as tiredness, sadness, and a loss of interest in their daily activities.\n\nThis study is known as an observational study, which means it collects health information about study participants after a healthcare professional has already prescribed treatment. Participants for this study will be found in the United States using a database from CVS Specialty Pharmacy. This will include anyone who was prescribed zuranolone between June 2025 and May 2026 and who filled the prescription within 1 year after the end of their pregnancy.\n\nThe main goal of this study is to learn more about how zuranolone affects the participants' PPD symptoms. This will be measured using a questionnaire completed by participants called the Edinburgh Postnatal Depression Scale, also known as the EPDS. A higher score on the EPDS may indicate more severe PPD symptoms.\n\nThe main question researchers want to answer in this study is:\n\n\\- Do PPD symptoms change after treatment with zuranolone based on EPDS scores measured at Day 15?\n\nResearchers will also learn more about:\n\n* Changes in participants' EPDS scores from before treatment to Day 45, which is 30 days after treatment ends.\n* How many participants breastfeed their babies while taking zuranolone\n* How many participants do not start new medicine after finishing their zuranolone treatment\n* How many participants take new medicines after finishing zuranolone\n* How many participants already tried other medicines for their depression symptoms before joining this study\n* How many participants take other medicines in general while taking zuranolone\n\nThis study will be done as follows:\n\nPeople who fill their zuranolone prescription through CVS Specialty Pharmacy will be contacted by email or phone to ask them about their interest in participating in the study.\n\nThose who agree to take part will answer written questions about their symptoms using the EPDS tool. They will also answer other survey questions about their background, environment, and general health information. Participants must take their first dose of zuranolone within 7 days of joining the study.\n\nParticipants will then be asked to answer questions using the EPDS tools, 15 days and 45 days after taking the first dose of zuranolone.",[72],"Depression, Postpartum","2025-07-30",{"date":75,"type":76},"2025-08-03","ACTUAL",{"date":78,"type":76},"2025-06-30",{"date":80,"type":68},"2026-08-24",{"name":5,"class":6},1]